Bioinformatics Jobs

Summary: Under the general supervision... of the Bioinformatics Scientist Department Manager Laboratory Directors and Pathologists and in accordance with established policies and procedures the Bioinformatics Analyst performs independently in the Department of Pathology. The Bioinformatics Analyst will be responsible for analyzing clinical Next Generation Sequencing data contributing to the development of data analysis pipelines and organizing and maintaining databases. Responsibilities: Participates in the daily clinical bioinformatics workflow such as DNA-seq and RNA-seq data analysis. Analyzes the clinical data for the validation of new Next Generation Sequencing tests. Assists with preparation of validation summaries of the new Next Generation Sequencing tests. Assists in developing analysis pipelines for Next Generation Sequencing tests. Evaluates analytical aspects of emerging analysis methods. Assists in the development of databases and webtools. Other information: BASIC KNOWLEDGE: Bachelor s Degree required. Master s Degree in Bioinformatics Computational Biology Computer Science or a related field is preferred. Demonstrates strong scientific understanding of genomics. Demonstrates proficiency in programming and scripting skills (e.g Perl Python or Java). Demonstrates knowledge of DNA-seq and RNA-seq data analysis tools (e.g. BWA GATK STAR Samtools). Demonstrates knowledge of database and webtool development (e.g. SQL HTML CSS Apache). Maintains up-to-date knowledge of bioinformatics data analysis tools Familiarity with CAP/CLIA lab setting is preferred but not required. EXPERIENCE: At least two years of industry or clinical lab experience. Experience in developing computational approaches for cancer genome and/or germline analysis is highly desirable. Excellent teamwork time management and organizational skills. WORK ENVIRONMENT AND PHYSICAL REQUIREMENTS: This position requires the Bioinformatics Analyst to work closely with Bioinformatics Scientists Medical Technologists Management Laboratory Directors and Pathologists. Ability to operate equipment and instruments and to perform all procedures within assigned laboratory section and interpret them for accuracy. Physical and visual dexterity necessary to conduct and interpret analysis. Visual strain is encountered while closely examining data. INDEPENDENT ACTION: Ability to work independently in a fast-paced multidisciplinary environment. Ability to multi-task and work on multiple clinical and developmental projects simultaneously. Analyst functions independently within the department s policies and procedures. Refers specific complex issues to the Bioinformatics Scientist Manager Laboratory Directors or Pathologists when clarification of policies and procedures is required. SUPERVISORY RESPONSIBILITY: None. Lifespan is an Equal Opportunity / Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race color religion sex national origin age ethnicity sexual orientation ancestry genetics gender identity or expression disability protected veteran or marital status. Lifespan is a VEVRAA Federal Contractor. Location: Rhode Island Hospital USA:RI:Providence Work Type: Full Time Shift: Shift 1 Union: Non-Union

Almaden Genomics is a cloud-native bioinformatics platform that accelerates research teams through streamlined, scalable, and interoperable genomic workflows. With a wide selection of biological databases and toolkits coupled with robust version control of modules and pipelines, entire teams can quickly drag, drop, and connect processes to create a simple visual representation of complex... bioinformatics workflow. All that’s left are streamlined genomic workflows that allow research teams to focus on the science. Position Summary: We are seeking a skilled and experienced Bioinformatician to join our dynamic team of engineers. The successful candidate will be responsible for analyzing and interpreting biological data, designing experiments, and developing computational methods to support customer needs. Duties & Responsibilities: • Analyze and interpret complex biological data using computational tools and statistical methods • Design and execute bioinformatics experiments, including genomic sequencing and analysis, transcriptomics, proteomics, and metabolomics • Collaborate with cross-functional teams to provide bioinformatics expertise and support • Present findings and results to research teams and stakeholders • Maintain knowledge of current trends and best practices in bioinformatics Requirements: • PhD or Master's degree in Bioinformatics, Computational Biology, or a related field • 1+ years industry experience in bioinformatics • Demonstrable strong programming skills in languages such as Python • Demonstrable experience developing bioinformatics pipelines • Experience with bioinformatics databases such as NCBI, Ensembl, UCSC Genome Browser, and others • Experience with data analysis and visualizations of large-scale data • Experience with containerized virtual environments such as Docker • Ability to work independently and manage multiple projects simultaneously Desired Skills: • Experience with single cell RNA-seq analyses • Experience building bioinformatic pipelines with a workflow language such as Nextflow, WDL, Snakemake, etc. • Experience with cloud computing platforms such as AWS or Google Cloud • Experience with Jupyter Notebooks If you are a passionate bioinformatician looking to make a tangible impact in the field of genomics, we encourage you to apply and join our dynamic team at Almaden Genomics. Together, let's shape the future of genomic research and medicine. At Almaden Genomics, we value diversity and always treat all employees and job applicants based on merit, qualifications, competence, and talent. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Culture & Benefits: Almaden Genomics has a culture that is a direct representation of our core values: • Do it with integrity • Bring passion • Be bold • Be respectful • Show humility • Take ownership • Have fun We highly value our employees and provide the following benefits: • Opportunity for equity ownership • Flexible PTO • 401K program • Excellent vision, dental and health benefits

Bioinformatics Analyst Interested in building a career in life sciences? An exciting mid-size Pharmaceutical company on the west coast is looking for talented Bioinformatics Analyst! The opportunity is a fully remote, 6 to 12 month contract-to-extend with benefits. There is an Oncology emphasis but all therapeutic backgrounds are encouraged to apply... The Bioinformatics Analyst will be responsible for: · Leading computational biology and data analysis efforts · Partnering with team members to develop robust data analysis pipelines · Communicating strategies and progress to cross-functional management · Integrating and interpreting heterogenous & noisy datasets from ongoing clinical trials The Bioinformatics Analyst should have the following qualifications: · Master's Degree in scientific discipline · Proficiency with R & Python with working knowledge of AWS · Experience with PowerBI, Tableau, or Splunk · 5+ years experience in the Life Sciences Benefits: · Opportunity for growth at an exciting Pharmaceutical company · Fully remote · Competitive pay rate If you are interested in the Bioinformatics Analyst role, then please don’t wait to apply. Please note this role is only offered on a W2 basis through EPM Scientific

SHIFT: Day (United States of America ... Seeking Breakthrough Makers Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation. At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career. CHOP’s Commitment to Diversity, Equity, and Inclusion CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children. We strongly encourage all candidates of diverse backgrounds and lived experiences to apply. A Brief Overview The Bioinformatics Engineer I position is an entry-level position in the support of computational environments focused on the management, transfer, formatting, and general processing of complex data types associated with genomics and proteomics. Whereas the Bioinformatics Scientist is primarily focused on the outcome of an analysis in terms of the scientific endpoint, the Bioinformatics Engineer is primarily focused on the outcome of an analysis in terms of validity, efficiency, and robustness. The focus of the position is basic systems implementation of data manipulation and analysis pipelines, applications, general hardware configurations, and bioinformatics-specific hardware configurations. Bioinformatics programming activities are also included. The Bioinformatics Engineer I primarily operates in a local environment as opposed to enterprise-level. The position allows for a wide variety of activities described within the job responsibilities and encompasses positions within both research and clinical environments. Activities occur with a high degree of supervision with low latitude for independent judgment. The Bioinformatics Engineer I will be introduced to the concepts of best practices in scripting, pipeline workflow development, hardware and software configurations, change controls, quality, sustainability, and documentation. The Bioinformatics Engineer I is primarily focused on supporting bioinformatics analytical groups and individuals as an engineering resource. What you will do • Computational Environment Development and Optimization (70%): Contribute to the maintenance and development of bioinformatics tool portfolio by developing knowledge of internally developed systems, open-source programs, and commercial applications. Provide efficient data management support. • Work with bioinformatics group members to develop functioning pipelines upstream of customized analysis workflows. • Maintain pipelines by staying current with evolving algorithms and standards and incorporating into pipeline • Optimize performance of applications by working with scientific computing and information systems groups to optimize hardware/software parameters • Define and prioritize requirements for pipeline development over time to incorporate new technologies and platforms via functional communication with bioinformatics group members and bioinformatics end users • Identify appropriate open-source and commercial products that serve needs of pipeline and/or customized analyses of end users. • Implement and maintain commercial and open-source software for common bioinformatics and genomics data analysis. • Implement, update and maintain locally stored data resources required for various analysis tasks. • Provide efficient data management support including file transfers, data formatting and manipulation, and basic integration of data from a variety of experimental and reference resources. • Maintain working knowledge of available commercial and openly accessible knowledgebase as they apply to bioinformatics analysis. • Collaboration and Mentorship (10%) • Collaborate primarily with bioinformatics scientist group and equivalents to produce local scale computational environments • Works with both bioinformatics group members and end users/clients to understand specific needs in bioinformatics and end user-specific domains • Attends group and team meetings and contributes primarily factual information regarding processes and approach • Provide ad hoc support and one-on-one and group-based training on key bioinformatics software, features, and workflows • Documentation and Standardization (20%): • Documents all aspects of computational environment parameters, instructions, and SOP's for existing systems and newly implemented systems. • Ensure that all routinely used tools (e.g. those included in shared analysis pipelines) are versioned and managed through a source control system. • Ensure that configuration files that provide parameters to algorithms and analysis software are versioned and managed through a source control system Education Qualifications • Bachelor's Degree Required • Master's Degree biological or computational discipline Preferred Experience Qualifications • At least one (1) year of experience in applied bioinformatics, computational, and genomics/proteomics areas Preferred Skills and Abilities • Strong UNIX/LINUX expertise required. • Experience with R strongly preferred • Experience with Python, Perl, or other languages preferred. • Experience with pipeline or workflow development frameworks preferred. • Experience with data management preferred. • Familiarity with open source and commercial bioinformatics resources and software preferred. • Experience with genomic data analysis preferred. • Experience or knowledge of technologies commonly used in biological labs, such as PCR, cloning, electrophoresis gels, and cell culture preferred. • Knowledge of the working mechanism of microarray, NGS, mass spectrometry, or other high-throughput technologies and awareness of their strengths and weaknesses, as well as applicability to a specific biological problem is preferred. • Familiarity with resources of genomic data sets and analysis tools, such as UCSC Genome Browser, Bioconductor, ENCODE, and NCBI databases is preferred. • Accountability and attention to timelines. • Excellent organization and communication skills with an emphasis on strong presentation skills • Ability to work in a team environment. To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, professionals working onsite—at any CHOP location, for any portion of time—must be vaccinated for COVID-19. Learn more. CHOP also requires employees who work in patient care buildings to receive an annual influenza vaccine. Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed. EEO / VEVRAA Federal Contractor | Tobacco Statement

HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10... million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role. Scientist – RNA Bioinformatics LIVE WHAT YOU WILL DO Let’s do this. Let’s change the world. We are actively seeking a highly qualified and motivated Scientist with a strong background in RNA bioinformatics. The scientist will join the Bioinformatics Technology team within Amgen’s Center for Research Acceleration by Digital Innovation (CRADI). CRADI is a multi-disciplinary effort embedded within our drug discovery engine that continually uses advancement in digital technologies for disease modeling and digital modality engineering to accelerate our pipeline from target inception through drug development. Bioinformatics Technologies plays a pivotal role within CRADI’s Computational Biology and Bioinformatics function, establishing an innovation engine for deploying and exploiting emerging digital technologies in the field of computational biology. RNA therapeutics comprise a rapidly expanding class of modalities that will fast-track solutions to the clinic. In this vital role you will lead the development and implementation of AI/ML models and optimization paradigms for the design of best-in-class RNA therapeutics. This position will involve close collaborative relationships with scientists within RNA therapeutic research, safety sciences, and therapeutic areas as well as data scientists and engineering partners across Amgen R&D. An ability to communicate clearly and collaborate effectively with colleagues from different fields will be essential. The successful candidate will possess strong analytical proficiency, have a high degree of technical competency in computational sciences with a deep theoretical understanding of machine learning paired with excellent understanding of RNA biology proven by a strong track record of innovative and collaborative research published through peer-reviewed publications. RESPONSIBILITIES: • Engage in collaborative efforts with stakeholders and subject matter experts to formulate technical solutions accelerating the development and increasing clinical efficacy of RNA therapeutic modalities • Find opportunities, set strategy, and deliver appropriate quantitative methods, such as discriminative and generative AI/ML models, to push the state of the art for optimizing RNA therapeutic modality design, formulation, and delivery • Consult on data generation and translate experimental findings into computational model design and refinement • Serve as subject matter expert on the intersection of computer science and RNA biology • Clearly document methods and analyses to allow reproducible research • Collaborate with engineers and data scientists to develop innovative bioinformatics tools that facilitate data access, model utilization, and output interpretation • Communicate project results and data-driven recommendations to stakeholders and cross-functional partners • Monitor, review, and critically interpret published computational research spanning RNA therapeutics and emerging oligonucleotide modalities • Proactively scope and deploy novel computational methods and digital technologies WIN WHAT WE EXPECT OF YOU We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications. BASIC QUALIFICATIONS: Doctorate degree Or Master’s degree and 4 years of computational biology, bioinformatics, biomedical data science or related field Or Bachelor’s degree and 6 years of computational biology, bioinformatics, biomedical data science or related field PREFERRED QUALIFICATIONS: • PhD in computer science, data science, computational biology or bioinformatics including industry experience • Deep experience in and theoretical understanding of statistical modeling, machine learning, deep learning, and other relevant quantitative methods • Knowledge in RNA biology, particularly RNA structure and function • Fluency in scientific programming and tool development with R, Python, or equivalents. Proficiency in C++ or Java is a plus. • Proven record of innovative thinking to propose and champion the development of novel algorithms and AI/ML models that generated interpretable and actionable results for practical applications • Experience with software development good practices, including code versioning, documentation, and testing, amongst others • Experience with cloud computing • Creative, open-minded, and passionate about scientific research • Demonstrated ability to thrive in a team environment • Strong interpersonal, collaborative, organizational, and presentation skills • Understanding of RNA therapeutic modality discovery and development is a plus THRIVE WHAT YOU CAN EXPECT OF US As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. The annual base salary range for this opportunity in the U.S. is $135,563 – $150,625. In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan • Stock-based long-term incentives • Award-winning time-off plans and bi-annual company-wide shutdowns • Flexible work models, including remote work arrangements, where possible APPLY NOW FOR A CAREER THAT DEFIES IMAGINATION Objects in your future are closer than they appear. Join us. CAREERS.AMGEN.COM Join Us If you’re seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you’ll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancers, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation

The Center for Public Health Genomics at the University of Virginia is looking to hire a Research Scientist. The Research Scientist will be responsible for working with the PI, Dr. Chongzhi Zang, and members in the lab to develop bioinformatics methods and to use integrative computational genomics approaches for studying epigenetics and transcriptional regulation in mammalian model cell systems... and human cancer. Projects will be performed in collaboration with basic and translational faculty in the Department of Biochemistry and Molecular Genetics. Dr. Yuh Hwa Wang’s laboratory is interested in the structure and function of unusual DNA sequences in living cells , and how these sequences cause genome instability and lead to human diseases. Dr. Garrett-Bakelman’s laboratory focuses on the use of functional genomics analyses and experiments to study biological mechanisms leading to Acute Myeloid Leukemia. The job responsibilities include: 1. conducting basic science research using existing and innovative computational biology approaches; 2. developing and maintaining bioinformatics tools used for computational biology research; 3. writing reports and manuscripts for peer-reviewed publications; 4. attending academic conferences (virtually and/or in-person) to present the research works; 5. mentoring and supervising trainees, including postdoctoral fellows, graduate and undergraduate students in the lab on computational biology research; 6. other research related work for the lab. Requirements: 1. Ph.D. or equivalent degree in quantitative science, such as bioinformatics, computational biology, computer science, statistics, applied mathematics, physics, data science, or a related field. 2. At least three-year research experience after completing the doctoral degree on computational epigenomics and high-throughput sequencing analysis. 3. Proficient in Python and R programming. 4. Working knowledge of molecular biology and genomics. 5. Strong academic communication skills and teamwork skills. 6. At least three first-author or senior-author publications in peer-reviewed journals in the related research field. To apply please visit UVA job board https://uva.wd1.myworkdayjobs.com/UVAJobs , and search for "R0025615" Complete the application and see below for documents to attach. Please note that multiple documents can be uploaded in the CV/Resume box. Required Application Materials: • CV • Cover Letter • Contact information for 3 references The selected candidate will be required to complete a background check at time of offer per University Policy. COVID Vaccination Requirement and Guidelines Please visitthe UVA COVID-19 Job Requirements and Guidelines webpageprior to applying for current information regarding vaccination requirementsandguidelines for employment at UVA. The University of Virginia, i ncluding the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information

The Division of Infectious Diseases and International Health is seeking a talented and passionate Bioinformatics Research Scientist to support ongoing bioinformatics analysis needs. The individual will integrate their knowledge and experience into current research and clinical efforts undertaken by two investigators, especially in analyzing large-scale genomic data with a focus on its... applications in the field of microbiology. There will be an expectation for research and development in public health emerging pathogen genomics with applications in metagenomics, comparative microbial genomic and mobile genetic elements. There will also be a need to maintain and develop, document, and validate comparative genomic analysis for speciation as well as strain comparison. The candidate will need to collaborate closely with the wet lab technologists and be comfortable handling appropriate private health information required with the clinical work. Overseeing the training of another bioinformatics scientists in running and maintaining the computing pipelines will be expected. Development in the area of pathogen genomics would be welcome and encouraged. This can include long read plasmid analysis and comparison to understand mobile resistance, metagenomics, antimicrobial resistance evaluation, data sharing, and development in computing efficiencies/pipeline development. There would also be opportunities for collaboration with public health, biocomplexity institutes, and hospital epidemiology. The candidate will have the opportunity to collaborate with additional faculty and public health leaders through the CDC Pathogen Genomic Center of Excellence on multiple distinct projects including microbiome, microbe strain relatedness, and developing and designing queries for virulence and resistance genes. The candidate is expected to work on the university-shared high-performance computing infrastructure that is tailor designed to address the substantial processing, networking, and data moving challenges arising from genomic science. The candidate will also be responsible for writing manuscripts describing their work and presenting at national/international conferences. Essential Duties and Responsibilities: • Collaborate extensively with Investigators and Faculty on all aspects of their research projects, from experimental design to data processing/analysis/visualization/exploration, as well as downstream statistical analysis for biological insights • Develop and implement automated NGS analysis workflows for genomic/metagenomics datasets • Ability to adapt to the highly dynamic nature of the bioinformatics field and contribute to the evaluation, testing, and implementation of new software packages and algorithms • Act as a liaison to various data science sections across the University of Virginia, including the health system data warehouse teams and the academic research computing teams • Provide bioinformatics consulting and data analysis/visualization support to various faculty. Train/mentor/supervise junior researchers who are interested in learning the recent developments in bioinformatics tools • In addition to the above job responsibilities, other duties may be assigned. Required Knowledge & Skills: • Understanding of next generation sequencing technologies and their applications, including Illumina, Nanopore, and PacBio platforms, is a must • Strong knowledge of working in a Linux environment; experience working on a high-performance computing cluster is desirable • Advanced proficiency in Python, Perl, or another scripting language • Advanced proficiency in R/Python (or other), for data management, data visualization and statistical analysis • Experience in using common open-source bioinformatics tools for analyzing next-generation sequence datasets • Prior experience working with prokaryotic whole genome sequencing data is desirable • Prior experience working with metagenomics/metatranscriptomics datasets for microbiome research is desirable • Familiarity with both structured (SQL) and/or unstructured (no-SQL) databases is desirable; not required • Prior experience using a workflow management system like Nextflow/Snakemake/WDL-Cromwell to setup, execute and monitor complex bioinformatics pipelines is desirable • Familiarity using version control tools like Git/Github • Motivated, independent and highly organized • Excellent written and oral communication skills Qualified candidates must have a Ph.D in computational biology, microbial genetics, bioinformatics, computer science, or a related field. A minimum of 2 years of related experience is preferred. This position is located in Charlottesville, VA. This is a restricted position; continuation is dependent on funding and satisfactory performance. This position will remain open until filled. The University will perform background checks on all new hires prior to employment. A completed pre-employment health screen is required for this position prior to employment. To Apply: Please apply through Workday , and search for R0042263. Complete an application online with the following documents: • CV • Cover letter • Contact information for 3 references Upload all materials into the resume submission field, multiple documents can be submitted into this one field. Alternatively, merge all documents into one PDF for submission. Internal applicants must apply through their UVA Workday profile by searching 'Find Jobs'. For questions about the application process, please contact Jessica Russo, Recruiter, at sxv9zv@virginia.edu . For more information about UVA and the Charlottesville community please see http://www.virginia.edu/life/charlottesville and https://embarkcva.com/ . COVID Vaccination Requirement and Guidelines Please visitthe UVA COVID-19 Job Requirements and Guidelines webpageprior to applying for current information regarding vaccination requirementsandguidelines for employment at UVA. The University of Virginia, i ncluding the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information

Job Summary The Bioinformatics department has an opening for a Data Scientist I. This role will employ a highly skilled data scientist with expertise in developing machine learning models to curate and analyze large, multi-modal datasets generated by the SimCenter at UT Southwestern Medical School. Experience with using machine learning for analyses of video-based data sets is a plus. They will... work closely with our software and AI engineers to ensure that the models are integrated into actionable user interfaces. Job Duties • Analyzes and develops formalisms, algorithms and software for applications in biomedical research. • Develops and maintains software tools and infrastructure for resolving specific problems. • Assists in the development, testing and revision of programs in a team with diverse bioinformatics expertise. • Performs other duties as assigned. Responsibilities: • Clean, organize, and analyze large, multi-model data sets • Build, train, test, and evaluate machine learning models on our proprietary data sets • Understand and implement the latest video-based machine learning models • Continuously improve the performance of the models by analyzing results and experimenting with different techniques • Collaboratively ensure the models are integrated into the user interfaces. Experience and Education M.S. in Computer Science, Bioinformatics, (Bio)mathematics, (Bio)statistics, Physics, Electrical Engineering, or related field OR B.S. with demonstrated experience in broadly defined areas of bioinformatics. 0 - 2 years post-graduation experience in data analysis and/or scientific software development. Technical Skills/Specifications: • Strong experience with Python and related data science libraries such as Pandas, Numpy, Scikit-learn. • Strong experience with machine learning frameworks such as Tensorflow or PyTorch. • Experience with video analysis with machine learning, specifically with CNNs and other deep learning models. • Experience with data visualization tools such as Matplotlib or Seaborn. • Strong understanding of data science and machine learning principles and best practices. • Experience with cloud platforms such as AWS or GCP. • Strong debugging and problem-solving skills. Why UT Southwestern? With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. At UT Southwestern, we invest in you with opportunities for career growth and development that align with your future goals and help to provide security for you and your family. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more that are all available on the day you start work. UT Southwestern is honored to be a Veteran Friendly work environment that is home to approximately 800 veterans. We value your integrity, dedication, and the commitment you’ve made to our country. We’re proud to support your next mission. Ranked by Forbes as one of the Top 10 National Employers, we invite you to be a part of the UT Southwestern team where you’ll discover teamwork, professionalism, and consistent opportunities for growth. This position is security-sensitive and subject to Texas Education Code §51.215, which authorizes UT Southwestern to obtain criminal history record information. UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. To learn more, please visit: https://jobs.utsouthwestern.edu/why-work-here/diversity-inclusion

BioSkryb is a venture-backed startup bringing new solutions for cellular heterogeneity in both the research and clinical space studies using our proprietary genome amplification system. BioSkryb’s ResolveDNA™ technology enables even coverage of the entire genome during DNA amplification and allows for unparalleled accuracy and uniformity in DNA sequence coverage and base calling. We believe our... technology will enable a new generation of single cell and low DNA genomics applications in diverse markets like cancer genomics, bacterial genomics, personal genomics and Minimal Residual Disease testing. We are seeking a Bioinformatics Analyst to join an exciting, fast-growing, and well-financed company to aid in the development of novel single cell sequencing applications. The individual will be at the ‘front lines’ of data analysis from external client base and internal R&D team. Regular work involves executing analytical workflows, summarize and interpret results across a range of applications. This extends to development of analytical systems, testing of applications in our commercial bioinformatics platform, BaseJumper. Familiarity with working in high performance computer environments, organizing and presenting results while maintaining biological understanding of results are required. Responsibilities • Analyze next generation sequencing data in the support of client projects, product development and chemistry enhancements • Maintain schedule of tasks so that project timeline expectations are met. Communication to internal / external stakeholders of shift to timelines • Report on quality control within guidelines established by company policy. Providing recommendations to quality criteria where appropriate • Routinely provide summarization of project results and visualizations to senior team members • Create documentation on analytical processes and interpretation of output from BaseJumper • Develop documentation of analyses conducted and/or analysis plans and specifications, as appropriate • Review and modify procedures for data management cycles, performing data auditing as necessary for proper curation of very large datasets • Generate novel tools as necessary Minimum Required Education and Experience • Bachelor’s Degree or educational equivalent in Bioinformatics, Molecular Biology, Statistics, Genomics or related field OR • Equivalent combination of education, training and experience of which bioinformatics is a strong component • Experience in analyzing NGS data: genomic or transcriptomic • Tool development in Python / R • Familiarity with common biological data formats, including transcript counting data, VCF, JSON, BAM • Experience with Linux and common command line tools • Clear oral and written communication skills, demonstrated code documentation • Ability to establish and maintain effective working relationships with coworkers, managers and clients • Above all, the ability and willingness to learn new skills and solve new challenges Preferred Experience • Familiarity with single-cell genomic datasets • Representing large datasets through platforms such as RShiny, Plotly, Tableau • Experience operating in cloud environment, preferably AWS (batch, lamda, eventBridge) • Understanding of cellular biology and/or cancer biology Physical Requirements • Extensive use of keyboard requiring repetitive motion of fingers • Regular sitting for extended periods of time BioSkryb Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law

Senior Scientist, Bioinformatics, Oncology R&D Gaithersburg, MD or Waltham, MA... AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. It is dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions for some of the world’s most serious diseases. At AstraZeneca Oncology, we are leading a revolution to redefine cancer care by pushing the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. Working with one of the broadest and deepest Oncology pipelines in the industry offers the exciting opportunity to impact the most novel molecules throughout development stages. The Early Data Science group delivers actionable insights through the application of computational science to all areas of AstraZeneca’s Oncology portfolio. It has substantial expertise and outstanding track record in bioinformatics and data science, undertaking both portfolio applied informatics research and the development of ground-breaking capabilities. Do you have expertise in bioinformatics/computational biology and immuno-oncology? Do you have experience deciphering complex clinical omics datasets? Do you have a passion for turning scientific discoveries and insights into life-changing medicines? Do you enjoy team work in a highly dynamic and innovative environment? This role at AstraZeneca might be the one for you! You will be based in our Gaithersburg MD or Waltham MA campus. What you’ll do The Early Data Science group is growing to meet the strategic challenges pursued by AZ Oncology. We are looking for a hardworking and motivated Senior Scientist to join our Late IO team. The role will focus on our expanding portfolio of bispecific assets and immuno-therapy containing regimes in clinical stage. You will • Work as an integrative part of bispecific or IO project teams and deliver bioinformatics expertise in a proactive manner • Identify impactful questions and apply state-of-art computational/system biology approaches to discover actionable insights from complex clinical genomic data • Build robust hypotheses along with comprehensive evidence packages by using wealth of AZ oncology trials, RWE and public databases as needed • Contribute translational findings to enable informed decision-making of Ph1/2/3 clinical trials and guide their design • Collaborate closely with our Translational Medicine Leads to drive effective data generation from clinical trials and help address technology/analytics gaps • Publish work in high impact journals with industry and academic partners to increase visibility of AZ data science Essential for the role • Relevant PhD (or MS degree with 4+ years applied experience), combining technical expertise in computational biology, bioinformatics, data science or applied biostatistic • A solid understanding of the molecular and/or immunological mechanisms driving cancer • Experience and knowledge with data from clinical trials or RWE is strongly desired • Skilled in effective communication of complex data, analysis and results to non-computational scientists and partner lines • The ability to successfully work in a matrix setting and manage multiple simultaneous priorities on tight deadlines • Programming proficiency (R and/or Python preferred) in a Linux environment of high performance computing Why AstraZeneca? At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, groundbreaking cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey. So, what’s next- Are you already envisioning yourself joining our team? Good! We can’t wait to hear from you! If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner. Closing Date: June 21, 2023 Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package. Where can I find out more? Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/ Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/ Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law