Bioinformatics Jobs

Position Summary Caris Life Sciences is looking for a sharp, driven and goal-oriented Bioinformatics Scientist to support our bioinformatics and statistical analysis leadership as well as novel biomarker discovery derived from Caris’ proprietary ADAPT Biotargeting SystemTM. These critical roles will work closely with our Bioinformatics & R&D teams to assist in designing experiments, analyzing... complex clinical and translational data sets. We are looking for team-oriented, hands-on professionals with a passion for personalized medicine and innovation in statistical and mathematical analyses. Job Responsibilities • Develop and maintain statistical analytical tools and bioinformatics pipelines. • Conduct analysis on biomarker discovery and clinical diagnostics data. • Consult on experiment design and data interpretation for laboratory research. • Contribute to design and development of informatics infrastructure. • Adhere to coding and documentation standards and manage deliverables for area of responsibility. Required Qualifications • Master’s or PhD in bioinformatics, biostatistics, biomedical engineering, computer science and other related disciplines. • Solid understanding of principles and analytical methodologies in computational biology and bioinformatics. • Hands-on experience of state-of-the-art bioinformatics tools, including NGS and proteomic pipelines strongly preferred. • Proven ability for developing and maintaining bioinformatics pipelines. • Experience in developing database and data-driven applications. • Programming skills with Perl, Python, shell scripting and/or Java. • Skills in statistical analysis and proficiency with statistical package such as R and SAS. • Ability to understand laboratory and clinical data. • Familiarity with clinical trial design and clinical data analysis is highly desirable. • Proficient verbal and written communication skills. Willingness to share and receive information and ideas from all levels of the organization in order to achieve the desired results. • Conditions of Employment: Individual must successfully complete pre-employment process, which includes criminal background check, drug screening and reference verification. Also, individual must be fully vaccinated for COVID-19 by the date of hire to be considered for U.S.-based jobs, if not currently employed by Caris Life Sciences. Training  • All job specific, safety, and compliance training are assigned based on the job functions associated with this employee.   This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability

The Position Roche Pharma Research and Early Development (pRED), an industry leader in pushing the boundaries of the sciences in drug development, is committed to develop more personalized healthcare solutions at lower cost to society. In order to continuously deliver more efficacious cancer immunotherapy, pRED is constantly utilizing all the data collected from all current and past clinical... trials to maximize the learning of our drugs and to drive fully data-driven decision making. One of such reverse translational efforts aims to establish clinically-relevant knowledge about immune escape mechanisms in cancer. We are looking for a passionate postdoctoral research fellow who will help us push the boundary of response to cancer immunotherapy through integrating OMICs data and applying machine learning. In this postdoc position, you will have the opportunity to: • Work with experts in cancer immunotherapy to analyze the first-hand data from clinical trials and make discoveries that benefit the patients • Contribute to a global data science team through leveraging and developing analytics pipelines and libraries for multiple OMICS data modalities • Publish and share your discoveries with the cancer research community We are looking for a highly motivated individual who has a passion for driving science through technology, spirit of teamwork, and excellent communication skills that will thrive in a multidisciplinary team to deliver best results. A successful candidate will have the following skills or experience: • Ph.D. degree in Bioinformatics, Computer Science, Biostatistics, Applied Mathematics, Applied Physics or related discipline. • Hands-on experience in processing and analyzing Next Generation Sequencing data (DNA-Seq & RNA-Seq) using common bioinformatics pipelines • Proficiency in Python and R • Experience in machine learning is a plus • Knowledge about genetics, immunology, tumor immunology and / or tumor biology and genetics is a plus Relocation benefits are available for this position #LI-PL1 #postdoc Who we are At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity. Unless entitled to a reasonable accommodation under applicable law, employees are required to be fully vaccinated against COVID-19 in accordance with customer requirements, the company’s health and safety obligations and/or applicable law or guidelines. Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual’s race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law. If you have a disability and need an accommodation in connection with the on-line application process, please email us at US.Accommodation@roche.com

The Position The Position... Genentech is inviting applications for a Computational Biologist to join the Department of Human Genetics as a Principal Scientist. Genentech has access to vast, and growing, repositories of genetic, genomic and clinical data, gathered from internal studies (including many of our trials), as well as collaborative and public external data sets. The Principal Scientist appointed to this position will play a pivotal role in developing and implementing analytical strategies that allow us to better integrate and interpret these data, delivering biological insights into disease pathophysiology that propel our translational goals, most obviously through the identification of novel therapeutic targets and biomarkers involved in disease onset and/or disease progression. • We are keen to attract candidates with skills and experience that position them to tackle key challenges in multimodal data integration as it relates to human biology. What strategies should we adopt for the effective and insightful integration of multimodal data at scale to deliver causal inference regarding disease pathogenesis? How can we do a better job of connecting the genetic signals that come from GWAS to the genes, pathways and processes through which they exert their effects on disease biology and outcomes? How can we optimize our capacity to integrate a diversity of data types, relevant to efficacy, safety and druggability, to prioritize the most promising targets for a given disease? To be successful, the person we seek will need to have a broad range of skills and expertise that embraces association analysis in genotype and sequence data, strong competence in the analysis of sequence-based molecular assay data (eg RNA-Seq), familiarity with approaches for the integration of genetic and molecular data, and a profound understanding of causal inference. They are also likely to be proficient in the use of high performance computing resources, and to have experience of implementing a range of AI/ML approaches. As well as developing and implementing a transformational research program in these areas, working closely with colleagues and mentors in human genetics, the appointee will be responsible for: • Extensive collaboration with colleagues across “Translational Genomics” who are responsible for the generation and analysis of data arising from our capabilities in molecular profiling, spatial analysis and perturbation assays • Extensive collaboration with colleagues in Neuroscience (and other Therapeutic Areas) who will take the biological insights generated and turn them into actionable hypotheses and lead molecules • Design and execution of targeted analyses to uncover novel therapeutic targets and biomarkers of disease heterogeneity, progression, and treatment response • Maintaining an excellent publication record • Presentation and communication of findings in cross-functional teams • Initiation of and participation in strategic external collaborations in pursuit of these goals. Genentech is committed to the development and delivery of precision medicines, which take individual variation as well as diagnosis into account in the delivery of health care. Because genetic makeup is a major component of individual variation, the work of the Human Genetics Department is a central pillar for achieving our vision of modern medicine, and the scientists in the Department are key contributors to making this happen. Major disease areas of interest to Genentech include a range of chronic inflammatory and neuro-degenerative conditions, as well as diverse cancers, and a number of ophthalmic and metabolic diseases. Though the principal focus of this position will be in Neuroscience, we expect the research findings to have broad relevance across all disease areas. Genentech provides an exceptional research environment composed of internationally recognized scientific leaders, as well as state of the art core facilities with cutting edge technologies and computational resources to support your research activities. We provide a highly collaborative community, and as such, you will interact closely with clinical development teams and other scientists in the areas of biomarkers, bioinformatics, and research discovery departments including Immunology, Neuroscience, Infectious Diseases, Cancer Immunotherapy, and Molecular Oncology. Qualified candidates will typically have the following attributes: • PhD training with a strong focus on human genetics, Computational Biology or a related field; • Substantial (typically at least 3-5y) experience in academia or industry (as a postdoc or equivalent role) engaged in computational biology research or a related field • A thorough understanding of biostatistics & statistical genetic methods • Extremely strong computational skills, with demonstrable competence in the management and analysis of large scale data, proficiency in high-level programming languages and statistical computing • An excellent record of scientific publications in top tier journals • Strong communication and interpersonal skills with the ability to present and explain findings to a diverse audience • Motivation and ability to succeed in a fast-paced, highly collaborative environment • A keen interest in applying computation to solve biological problems and achieve translational goals • A scientific background in neuroscience would be a plus, but is not essential • Experience in the application of AI/ML methods would be a major plus • #gREDinformatics Who We Are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation

SENIOR BIOINFORMATICS SOFTWARE ENGINEER SAN FRANCISCO BAY AREA (hybrid/remote... $160,000 - $180,000 + BENEFITS This diagnostic company is revolutionizing NIPT through novel scientific breakthroughs to empower parents to understand the future risks of their children. THE COMPANY This seed-stage start up already has a product on the market and is looking for a talented bioinformatics software engineer to join their mission of empowering parents. Using Python, DNA sequencing and WGS analysis, and AWS, this bioinformatics engineer will spearhead the tooling development and bioinformatics analysis. THE ROLE Responsibilities will include: • Developing bioinformatics pipelines using Python on AWS • Analyzing DNA sequencing, Whole Genome Sequencing (WGS) and rare variant data • Collaborating with internal and external stakeholders in driving company mission • Scaling and automating exisiting pipelines YOUR SKILLS AND EXPERIENCE Your skills include: • Graduate degree in Bioinformatics, Computational Biology or related fields • Demonstrated industry experience developing production level bioinformatics pipelines • Significant industry experience in developing THE BENEFITS • $160,000 - $180,000 base salary • Opportunity for rapid growth, drive microbiome development and strategy, and more! HOW TO APPLY Please register your interest by sending your CV to Alyssa Liew via the Apply link on this page

PharmEng Technology has been providing quality services to leading manufacturers of healthcare and pharmaceutical products since 1997. Our specialists hold expertise in Commissioning & Qualification, Validation, Quality Systems, Regulatory Affairs, Engineering, and Training to ensure that our clients can keep on providing the world with their cost-effective and high-standard healthcare... products. At PharmEng Technology, we strive to cultivate the best working environment where empowerment, passion and perseverance are nurtured while serving our clients to achieve their unique business goals. We are seeking an experienced Bioinformatics Scientist for an opportunity in the Bay Area, CA. Objectives Of This Role • Provide computational and informatics support to scientists and independent faculty members in designing and executing key biomedical projects; serve as a subject matter expert. • Responsible for the collection, analysis, interpretation and integration of complex biomedical data. • Own and lead various projects, delivering results and generating relevant reports. • Contribute expertise to software code base and relevant communities of practice. • Work as part of a broader team to identify and implement long term solutions; improve quality, speed and efficacy of current projects and program through evaluating and benchmarking new software tools and pipeline development. Skills And Qualifications • Bachelor's degree in relevant field required. Advanced degree (Master's or PhD) preferred with evidence of impact in bioinformatics applied to real life problems, ideally within a biomedical research or clinical environment. • 3+ years of experience in basic, translational or clinical research setting required. • Deep bioinformatics skills at the interface between bioinformatics programming and understanding of biological and clinical problems. • Excellent communication and effective problem-solving skills, track record in serving a variety of diverse customers and projects. • Proven ability to work independently, prioritize, and manage people if needed, within an environment with evolving priorities

The Department of Molecular, Cell, and Developmental Biology and the Genomics Institute at the University of California, Santa Cruz (UCSC) invites applications for the position of Bioinformatics Project Scientist. Under the direction of Professor Sofie Salama, the project scientist will lead the design and execution of bioinformatic analysis of genomic data and wet lab experimental results by... Salama laboratory members and initiate independent research projects in the general focus areas of the laboratory (transposable elements, segmental duplications, neurodevelopment, evolution of the primate brain, organoid models, pediatric glioma). The incumbent will work with trainees (undergraduate and graduate students as well as postdocs) to assist and train them in best practices of bioinformatic analysis and data sharing through publicly accessible databases. The project scientist will contribute to the writing of grants and scientific publications related to their projects and will present their work at national and international conferences. The project scientist will collaborate with other research groups at UCSC and other institutions to develop and implement best practices for data analysis and sharing methods, especially as they pertain to collaborative projects. Applicants with expertise in complex genomic regions including transposable elements in the context of primate evolution, neurodevelopment, or cancer biology are strongly encouraged to apply. In addition to a very strong bioinformatics training and research track, the successful candidate should have experience in wet lab experimentation. The hiring unit will not sponsor employment-eligible immigration statuses for this position

At Alector, our mission is to develop therapies that empower the immune system to combat neurodegeneration and cancer. Our team is solely focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, leading healthcare investors, and pharma company partners who share in our... commitment to bettering the lives of patients. As a Scientist for the Bioinformatic’s team, you will play an important role in every aspect of Alector scientific mission, from target discovery to pre-clinical and clinical phases. You will work closely with and under the mentorship of our senior scientists to discover and develop novel drugs targeting neurodegenerative disorders and cancer. As part of a talented and multi-disciplinary bioinformatics team you have a transversal role and interact closely with scientists from different fields. You will carry out valuable analyses which will further Alector’s collective scientific understanding. #LI-RS1 Alector is a phenomenal place to learn and grow. Alector is a dynamic environment where teams are encouraged to experiment, take ownership of decisions, and question convention to solve complex problems. At Alector, we value shared wins, perseverance, and a growth mindset. Alector was named on Fortune’s "Best Workplaces in Biopharma" top list for small and medium-sized companies for the second year! And we moved up from #16 to #11 in 2022. Among the things you'll discover at Alector on Day 1 and throughout your tenure: Committed and driven colleagues, a bold and important company goal, brand-new brightly lit offices in Oyster Point, right at the heart of Biotech Bay. Alector offers flexible remote work options, and competitive compensation and benefits. Come join us! At Alector, we believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws. Employees of Alector working on-site are required to be vaccinated against COVID-19, and are required to provide proof of vaccination. Employees may be entitled to an exception or reasonable accommodation if they cannot be vaccinated because of a disability/medical necessity, or sincerely held religious belief. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation

The Position Bioinformatics Cloud Software Engineer... Genentech seeks a talented and highly motivated Software Engineer to develop a cloud based genomic analysis system in support of our Translational Genomics efforts. Our Translational Genomics efforts span the interface of human genetics, functional genomics, molecular biology, disease model engineering, tissue and cellular profiling, and advanced computational methodology. The primary focus of this position is to extend our existing orchestration system for large scale genomic analysis workflows into the cloud to enable Genentech researchers to scale the throughput of their genomic and genetic analyses as needed. Solutions will need to integrate cloud native concepts with microservice based components in an existing software ecosystem. A successful candidate will collaborate with interdisciplinary teams of Software Engineers, DevOps engineers and Computational Biology Scientists to design and implement cloud native software solutions with an emphasis on service-oriented architecture and containerized workflows. The work includes requirements gathering, design and architecture, as well as backend and frontend development. The candidate will use best practices of continuous integration and software delivery to accommodate the fast pace of innovation in Genentech Research. Successful candidates will meet many of the following requirements: • You have a Masters degree or equivalent in Software Engineering, Computer Science, Bioinformatics, or similar and 6-10 years of relevant experience in an academic or commercial setting. • You have successfully planned and implemented multiple software projects throughout the whole development cycle (planning, implementation, testing, release, maintenance) following modern software development practices. • You are a full-stack software developer (backend+frontend) that if needed maintains its own dev-ops tool chain, but plays well with enterprise level solutions. • You are able to break down large problems into smaller microservice based components and can develop them independently or as part of a large team. • You have experience with cloud related concepts such as deployment via Kubernetes or AWS cloud formation, Monitoring and containerization. • Experiences and expertise with cloud related concepts such as building infrastructure using Terraform, AWS Cloud Formation, AWS Batch, Lambda and Code Pipeline is a must - an AWS certification on an associate level is a plus. • You have architected distributed systems with infrastructure automation, monitoring and alerting and you are familiar with troubleshooting distributed systems. • You have a focus on high-quality code, including automated testing and coding best practices and you are able to prepare and conduct code reviews. • You have experience with relational and non-relational DB technologies. Knowledge of other search, messaging and queuing technologies such as ElasticSearch, SOLR, RabbitMQ and Kafka are desirable. • You are a quick learner and your analytical skills help you to effectively translate technical and scientific process requirements into a software product. • You have strong experience in the use of a high-level, object oriented programming language such as Python, Go or Java and a strong understanding of Linux/Unix. • You are comfortable working both independently and collaboratively, and with handling several concurrent, fast-paced projects. • You are able to execute technical projects at global scale, across multiple teams and time zones. Strategic, analytical mindset and ability to innovate using technology to advance business goals. • Experience in managing data according to FAIR principles as well as tracking data lineage, ensuring data quality and improving data discovery is a plus. • You have strong communication skills and can untangle and discuss complex technical tasks. • Prior experience in a life science or drug development environment are beneficial. What to expect from us • A highly collaborative and dynamic research environment where we aim to advance the rate of scientific discovery using purposefully built solutions. • Access to large data sets, samples and compute resources. • Access to state-of-the-art technologies and pioneering research. • Participation in seminar series featuring academic and industry scientists. • Campus-like lifestyle with a healthy work-life balance. • Mentored opportunities to further develop professional skills. Relocation benefits are available for this job posting. #LI-EJ2 #bioinformatics #gREDinformatics Who we are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. We are a research-driven biotechnology company, whose medical innovations for cancer and other serious illnesses make a difference for patients across the globe. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page. Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation

The Company Interline Therapeutics leverages unique capabilities in proteomics, structural biology, and computational chemistry to elucidate protein communities and develop new medicines that target key drivers of inflammation and cancer. Interline is creating a culture centered around our dual commitments to patients and employees. We believe that if we prioritize science and innovation... empower one another, and have fun, we will significantly improve the lives of patients. We are growing a diverse and inclusive team with individuals that are action-oriented and united by common values. The Role We are seeking a talented Structural Bioinformatics Scientist experienced in computational structure prediction methods and integrative modeling of protein complexes using experimental constraints. As part of Interline's expanding community and growing bioinformatics team, you will collaborate with bioinformaticians, proteomics scientists, structural biologists and other scientific experts to translate novel protein interaction insights into actionable structural models for drug discovery. In this role you will drive the development and application of cutting-edge structural approaches to model therapeutic targets in their relevant context, and enable multiple drug discovery programs by prioritizing testable hypotheses. This position is based in our South San Francisco offices, with the possibility to work remotely. The Successful Candidate Will • Develop computational models of protein complex structures from biophysical experiments • Implement cutting-edge tools for ab initio prediction of multimeric protein structures, interface identification and binding free energy calculation on our cloud computing platform • Collaborate with analytical scientists, bioinformaticians and drug discovery teams to model interaction communities for therapeutic targets and provide actionable structural and mechanistic insights • Develop and apply computational tools for predicting the effect of perturbations (genetic variants, drug target engagement) on protein communities • Liaise with collaborators and CRO's to design, execute and analyze model validation experiments • Engage with computational chemistry and molecular simulation teams to develop models and methods to improve the accuracy of ligand-binding predictions • Assist in the featurization of structural "big data" for training in-house machine-learning models. Translate biophysics to code. Qualifications • PhD in computational biophysics/chemistry, physical chemistry/chemical physics, applied mathematics or relevant field with 5+ years of post-graduate experience in academia or the pharmaceutical/biotech Industry; proven track-record of scientific excellence as evidenced by a strong publication and/or patent record. • In-depth knowledge of commonly used computational structure prediction servers such as Rosetta, AlphaFold2; experience with protein-protein, protein-peptide docking or ab initio interaction prediction preferred • Experience with empirical force fields for rapid binding energy calculations • Working proficiency in UNIX/Linux and extensive programming experience in Python and/or C/C++; experience with cloud computing and workflow orchestration tools would be advantageous • Working knowledge of Machine Learning algorithms and optimization techniques • Experience with structure modeling from biophysical experiments such as NMR, HDX, SAXS or CryoEM; experience with Mass Spectrometry based structural proteomics methods such as XL-MS would be considered a significant advantage • Strong interpersonal skills and a desire and flexibility to work within a dynamic multidisciplinary team environment All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or disability

BIOINFORMATICS ENGINEER BAY AREA OR REMOTE... $95,000-$105,000 THE COMPANY This global biotech leader is searching for a Bioinformatics Engineer to join its team. This will be an entry-level role working closely with their computational team. They work on the development of kits, reagents, and instruments to develop tools to accelerate discovery efforts. Role & Responsibilities: • Building cloud infrastructure for bioinformatics scientists • Build internal web apps for scientists • Work closely with R&D, sales, and technical support teams Skills: • Bachelors or Masters with 1-2 years industry experience or PhD with no industry experience in Computer Science, Bioinformatics, or other quantitative related fields • Python or Java • Cloud experience with a preference for AWS • Docker or CI/CD experience • Web app development experience Benefits: $95,000-$105,000 Bonus Remote potential Please apply and send your CV