Bioinformatics Jobs

The Position The Position... Genentech is inviting applications for a Computational Biologist to join the Department of Human Genetics as a Principal Scientist. Genentech has access to vast, and growing, repositories of genetic, genomic and clinical data, gathered from internal studies (including many of our trials), as well as collaborative and public external data sets. The Principal Scientist appointed to this position will play a pivotal role in developing and implementing analytical strategies that allow us to better integrate and interpret these data, delivering biological insights into disease pathophysiology that propel our translational goals, most obviously through the identification of novel therapeutic targets and biomarkers involved in disease onset and/or disease progression. • We are keen to attract candidates with skills and experience that position them to tackle key challenges in multimodal data integration as it relates to human biology. What strategies should we adopt for the effective and insightful integration of multimodal data at scale to deliver causal inference regarding disease pathogenesis? How can we do a better job of connecting the genetic signals that come from GWAS to the genes, pathways and processes through which they exert their effects on disease biology and outcomes? How can we optimize our capacity to integrate a diversity of data types, relevant to efficacy, safety and druggability, to prioritize the most promising targets for a given disease? To be successful, the person we seek will need to have a broad range of skills and expertise that embraces association analysis in genotype and sequence data, strong competence in the analysis of sequence-based molecular assay data (eg RNA-Seq), familiarity with approaches for the integration of genetic and molecular data, and a profound understanding of causal inference. They are also likely to be proficient in the use of high performance computing resources, and to have experience of implementing a range of AI/ML approaches. As well as developing and implementing a transformational research program in these areas, working closely with colleagues and mentors in human genetics, the appointee will be responsible for: • Extensive collaboration with colleagues across “Translational Genomics” who are responsible for the generation and analysis of data arising from our capabilities in molecular profiling, spatial analysis and perturbation assays • Extensive collaboration with colleagues in Neuroscience (and other Therapeutic Areas) who will take the biological insights generated and turn them into actionable hypotheses and lead molecules • Design and execution of targeted analyses to uncover novel therapeutic targets and biomarkers of disease heterogeneity, progression, and treatment response • Maintaining an excellent publication record • Presentation and communication of findings in cross-functional teams • Initiation of and participation in strategic external collaborations in pursuit of these goals. Genentech is committed to the development and delivery of precision medicines, which take individual variation as well as diagnosis into account in the delivery of health care. Because genetic makeup is a major component of individual variation, the work of the Human Genetics Department is a central pillar for achieving our vision of modern medicine, and the scientists in the Department are key contributors to making this happen. Major disease areas of interest to Genentech include a range of chronic inflammatory and neuro-degenerative conditions, as well as diverse cancers, and a number of ophthalmic and metabolic diseases. Though the principal focus of this position will be in Neuroscience, we expect the research findings to have broad relevance across all disease areas. Genentech provides an exceptional research environment composed of internationally recognized scientific leaders, as well as state of the art core facilities with cutting edge technologies and computational resources to support your research activities. We provide a highly collaborative community, and as such, you will interact closely with clinical development teams and other scientists in the areas of biomarkers, bioinformatics, and research discovery departments including Immunology, Neuroscience, Infectious Diseases, Cancer Immunotherapy, and Molecular Oncology. Qualified candidates will typically have the following attributes: • PhD training with a strong focus on human genetics, Computational Biology or a related field; • Substantial (typically at least 3-5y) experience in academia or industry (as a postdoc or equivalent role) engaged in computational biology research or a related field • A thorough understanding of biostatistics & statistical genetic methods • Extremely strong computational skills, with demonstrable competence in the management and analysis of large scale data, proficiency in high-level programming languages and statistical computing • An excellent record of scientific publications in top tier journals • Strong communication and interpersonal skills with the ability to present and explain findings to a diverse audience • Motivation and ability to succeed in a fast-paced, highly collaborative environment • A keen interest in applying computation to solve biological problems and achieve translational goals • A scientific background in neuroscience would be a plus, but is not essential • Experience in the application of AI/ML methods would be a major plus • #gREDinformatics Who We Are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation

SENIOR BIOINFORMATICS SOFTWARE ENGINEER SAN FRANCISCO BAY AREA (hybrid/remote... $160,000 - $180,000 + BENEFITS This diagnostic company is revolutionizing NIPT through novel scientific breakthroughs to empower parents to understand the future risks of their children. THE COMPANY This seed-stage start up already has a product on the market and is looking for a talented bioinformatics software engineer to join their mission of empowering parents. Using Python, DNA sequencing and WGS analysis, and AWS, this bioinformatics engineer will spearhead the tooling development and bioinformatics analysis. THE ROLE Responsibilities will include: • Developing bioinformatics pipelines using Python on AWS • Analyzing DNA sequencing, Whole Genome Sequencing (WGS) and rare variant data • Collaborating with internal and external stakeholders in driving company mission • Scaling and automating exisiting pipelines YOUR SKILLS AND EXPERIENCE Your skills include: • Graduate degree in Bioinformatics, Computational Biology or related fields • Demonstrated industry experience developing production level bioinformatics pipelines • Significant industry experience in developing THE BENEFITS • $160,000 - $180,000 base salary • Opportunity for rapid growth, drive microbiome development and strategy, and more! HOW TO APPLY Please register your interest by sending your CV to Alyssa Liew via the Apply link on this page

PharmEng Technology has been providing quality services to leading manufacturers of healthcare and pharmaceutical products since 1997. Our specialists hold expertise in Commissioning & Qualification, Validation, Quality Systems, Regulatory Affairs, Engineering, and Training to ensure that our clients can keep on providing the world with their cost-effective and high-standard healthcare... products. At PharmEng Technology, we strive to cultivate the best working environment where empowerment, passion and perseverance are nurtured while serving our clients to achieve their unique business goals. We are seeking an experienced Bioinformatics Scientist for an opportunity in the Bay Area, CA. Objectives Of This Role • Provide computational and informatics support to scientists and independent faculty members in designing and executing key biomedical projects; serve as a subject matter expert. • Responsible for the collection, analysis, interpretation and integration of complex biomedical data. • Own and lead various projects, delivering results and generating relevant reports. • Contribute expertise to software code base and relevant communities of practice. • Work as part of a broader team to identify and implement long term solutions; improve quality, speed and efficacy of current projects and program through evaluating and benchmarking new software tools and pipeline development. Skills And Qualifications • Bachelor's degree in relevant field required. Advanced degree (Master's or PhD) preferred with evidence of impact in bioinformatics applied to real life problems, ideally within a biomedical research or clinical environment. • 3+ years of experience in basic, translational or clinical research setting required. • Deep bioinformatics skills at the interface between bioinformatics programming and understanding of biological and clinical problems. • Excellent communication and effective problem-solving skills, track record in serving a variety of diverse customers and projects. • Proven ability to work independently, prioritize, and manage people if needed, within an environment with evolving priorities

The Department of Molecular, Cell, and Developmental Biology and the Genomics Institute at the University of California, Santa Cruz (UCSC) invites applications for the position of Bioinformatics Project Scientist. Under the direction of Professor Sofie Salama, the project scientist will lead the design and execution of bioinformatic analysis of genomic data and wet lab experimental results by... Salama laboratory members and initiate independent research projects in the general focus areas of the laboratory (transposable elements, segmental duplications, neurodevelopment, evolution of the primate brain, organoid models, pediatric glioma). The incumbent will work with trainees (undergraduate and graduate students as well as postdocs) to assist and train them in best practices of bioinformatic analysis and data sharing through publicly accessible databases. The project scientist will contribute to the writing of grants and scientific publications related to their projects and will present their work at national and international conferences. The project scientist will collaborate with other research groups at UCSC and other institutions to develop and implement best practices for data analysis and sharing methods, especially as they pertain to collaborative projects. Applicants with expertise in complex genomic regions including transposable elements in the context of primate evolution, neurodevelopment, or cancer biology are strongly encouraged to apply. In addition to a very strong bioinformatics training and research track, the successful candidate should have experience in wet lab experimentation. The hiring unit will not sponsor employment-eligible immigration statuses for this position

At Alector, our mission is to develop therapies that empower the immune system to combat neurodegeneration and cancer. Our team is solely focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, leading healthcare investors, and pharma company partners who share in our... commitment to bettering the lives of patients. As a Scientist for the Bioinformatic’s team, you will play an important role in every aspect of Alector scientific mission, from target discovery to pre-clinical and clinical phases. You will work closely with and under the mentorship of our senior scientists to discover and develop novel drugs targeting neurodegenerative disorders and cancer. As part of a talented and multi-disciplinary bioinformatics team you have a transversal role and interact closely with scientists from different fields. You will carry out valuable analyses which will further Alector’s collective scientific understanding. #LI-RS1 Alector is a phenomenal place to learn and grow. Alector is a dynamic environment where teams are encouraged to experiment, take ownership of decisions, and question convention to solve complex problems. At Alector, we value shared wins, perseverance, and a growth mindset. Alector was named on Fortune’s "Best Workplaces in Biopharma" top list for small and medium-sized companies for the second year! And we moved up from #16 to #11 in 2022. Among the things you'll discover at Alector on Day 1 and throughout your tenure: Committed and driven colleagues, a bold and important company goal, brand-new brightly lit offices in Oyster Point, right at the heart of Biotech Bay. Alector offers flexible remote work options, and competitive compensation and benefits. Come join us! At Alector, we believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws. Employees of Alector working on-site are required to be vaccinated against COVID-19, and are required to provide proof of vaccination. Employees may be entitled to an exception or reasonable accommodation if they cannot be vaccinated because of a disability/medical necessity, or sincerely held religious belief. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, perform essential job functions, and receive other benefits and privileges of employment. Please contact us to request accommodation

The Position Bioinformatics Cloud Software Engineer... Genentech seeks a talented and highly motivated Software Engineer to develop a cloud based genomic analysis system in support of our Translational Genomics efforts. Our Translational Genomics efforts span the interface of human genetics, functional genomics, molecular biology, disease model engineering, tissue and cellular profiling, and advanced computational methodology. The primary focus of this position is to extend our existing orchestration system for large scale genomic analysis workflows into the cloud to enable Genentech researchers to scale the throughput of their genomic and genetic analyses as needed. Solutions will need to integrate cloud native concepts with microservice based components in an existing software ecosystem. A successful candidate will collaborate with interdisciplinary teams of Software Engineers, DevOps engineers and Computational Biology Scientists to design and implement cloud native software solutions with an emphasis on service-oriented architecture and containerized workflows. The work includes requirements gathering, design and architecture, as well as backend and frontend development. The candidate will use best practices of continuous integration and software delivery to accommodate the fast pace of innovation in Genentech Research. Successful candidates will meet many of the following requirements: • You have a Masters degree or equivalent in Software Engineering, Computer Science, Bioinformatics, or similar and 6-10 years of relevant experience in an academic or commercial setting. • You have successfully planned and implemented multiple software projects throughout the whole development cycle (planning, implementation, testing, release, maintenance) following modern software development practices. • You are a full-stack software developer (backend+frontend) that if needed maintains its own dev-ops tool chain, but plays well with enterprise level solutions. • You are able to break down large problems into smaller microservice based components and can develop them independently or as part of a large team. • You have experience with cloud related concepts such as deployment via Kubernetes or AWS cloud formation, Monitoring and containerization. • Experiences and expertise with cloud related concepts such as building infrastructure using Terraform, AWS Cloud Formation, AWS Batch, Lambda and Code Pipeline is a must - an AWS certification on an associate level is a plus. • You have architected distributed systems with infrastructure automation, monitoring and alerting and you are familiar with troubleshooting distributed systems. • You have a focus on high-quality code, including automated testing and coding best practices and you are able to prepare and conduct code reviews. • You have experience with relational and non-relational DB technologies. Knowledge of other search, messaging and queuing technologies such as ElasticSearch, SOLR, RabbitMQ and Kafka are desirable. • You are a quick learner and your analytical skills help you to effectively translate technical and scientific process requirements into a software product. • You have strong experience in the use of a high-level, object oriented programming language such as Python, Go or Java and a strong understanding of Linux/Unix. • You are comfortable working both independently and collaboratively, and with handling several concurrent, fast-paced projects. • You are able to execute technical projects at global scale, across multiple teams and time zones. Strategic, analytical mindset and ability to innovate using technology to advance business goals. • Experience in managing data according to FAIR principles as well as tracking data lineage, ensuring data quality and improving data discovery is a plus. • You have strong communication skills and can untangle and discuss complex technical tasks. • Prior experience in a life science or drug development environment are beneficial. What to expect from us • A highly collaborative and dynamic research environment where we aim to advance the rate of scientific discovery using purposefully built solutions. • Access to large data sets, samples and compute resources. • Access to state-of-the-art technologies and pioneering research. • Participation in seminar series featuring academic and industry scientists. • Campus-like lifestyle with a healthy work-life balance. • Mentored opportunities to further develop professional skills. Relocation benefits are available for this job posting. #LI-EJ2 #bioinformatics #gREDinformatics Who we are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. We are a research-driven biotechnology company, whose medical innovations for cancer and other serious illnesses make a difference for patients across the globe. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page. Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation

The Company Interline Therapeutics leverages unique capabilities in proteomics, structural biology, and computational chemistry to elucidate protein communities and develop new medicines that target key drivers of inflammation and cancer. Interline is creating a culture centered around our dual commitments to patients and employees. We believe that if we prioritize science and innovation... empower one another, and have fun, we will significantly improve the lives of patients. We are growing a diverse and inclusive team with individuals that are action-oriented and united by common values. The Role We are seeking a talented Structural Bioinformatics Scientist experienced in computational structure prediction methods and integrative modeling of protein complexes using experimental constraints. As part of Interline's expanding community and growing bioinformatics team, you will collaborate with bioinformaticians, proteomics scientists, structural biologists and other scientific experts to translate novel protein interaction insights into actionable structural models for drug discovery. In this role you will drive the development and application of cutting-edge structural approaches to model therapeutic targets in their relevant context, and enable multiple drug discovery programs by prioritizing testable hypotheses. This position is based in our South San Francisco offices, with the possibility to work remotely. The Successful Candidate Will • Develop computational models of protein complex structures from biophysical experiments • Implement cutting-edge tools for ab initio prediction of multimeric protein structures, interface identification and binding free energy calculation on our cloud computing platform • Collaborate with analytical scientists, bioinformaticians and drug discovery teams to model interaction communities for therapeutic targets and provide actionable structural and mechanistic insights • Develop and apply computational tools for predicting the effect of perturbations (genetic variants, drug target engagement) on protein communities • Liaise with collaborators and CRO's to design, execute and analyze model validation experiments • Engage with computational chemistry and molecular simulation teams to develop models and methods to improve the accuracy of ligand-binding predictions • Assist in the featurization of structural "big data" for training in-house machine-learning models. Translate biophysics to code. Qualifications • PhD in computational biophysics/chemistry, physical chemistry/chemical physics, applied mathematics or relevant field with 5+ years of post-graduate experience in academia or the pharmaceutical/biotech Industry; proven track-record of scientific excellence as evidenced by a strong publication and/or patent record. • In-depth knowledge of commonly used computational structure prediction servers such as Rosetta, AlphaFold2; experience with protein-protein, protein-peptide docking or ab initio interaction prediction preferred • Experience with empirical force fields for rapid binding energy calculations • Working proficiency in UNIX/Linux and extensive programming experience in Python and/or C/C++; experience with cloud computing and workflow orchestration tools would be advantageous • Working knowledge of Machine Learning algorithms and optimization techniques • Experience with structure modeling from biophysical experiments such as NMR, HDX, SAXS or CryoEM; experience with Mass Spectrometry based structural proteomics methods such as XL-MS would be considered a significant advantage • Strong interpersonal skills and a desire and flexibility to work within a dynamic multidisciplinary team environment All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or disability

BIOINFORMATICS ENGINEER BAY AREA OR REMOTE... $95,000-$105,000 THE COMPANY This global biotech leader is searching for a Bioinformatics Engineer to join its team. This will be an entry-level role working closely with their computational team. They work on the development of kits, reagents, and instruments to develop tools to accelerate discovery efforts. Role & Responsibilities: • Building cloud infrastructure for bioinformatics scientists • Build internal web apps for scientists • Work closely with R&D, sales, and technical support teams Skills: • Bachelors or Masters with 1-2 years industry experience or PhD with no industry experience in Computer Science, Bioinformatics, or other quantitative related fields • Python or Java • Cloud experience with a preference for AWS • Docker or CI/CD experience • Web app development experience Benefits: $95,000-$105,000 Bonus Remote potential Please apply and send your CV

OPPORTUNITY Mammoth is seeking a Bioinformatics Scientist II to join its growing team. The successful candidate will contribute towards Mammoth’s efforts to develop safe and effective therapeutic treatments for genetic diseases. The Scientist II, Bioinformatics will work closely with researchers, development teams and external partners to establish statistical analysis tools, help design assays... and produce insights on the effects of our novel CRISPR systems. The scientist will also interact closely with the computational team to define and use internal tooling. KEY RESPONSIBILITIES • Design statistical analysis pipelines for multi-omics data • Work closely with the platform team to help optimize our novel CRISPR system • Communicate your solutions to a team of software and data engineers • Organize and present data in internal and external meetings • Other duties as assigned REQUIRED QUALIFICATIONS • Experience working with cloud resources in AWS • Experience communicating and visualizing results to computational and scientific teams • Experience analyzing CRISPR related assays • Proficiency in R • Experience working with modeling lab assays with LIMS system • Experience working with workflow management systems (Prefect, Airflow, Nextflow) • Experience writing code in a production environment (CI/CD, testing) PREFERRED QUALIFICATIONS • PhD with 1+ years of experience, MS with 4+ years of experience, or BS with 6+ years of experience in Computer Science, Bioinformatics, Computational Biology, Biostatistics, or a related field • Experience in developing bioinformatic pipelines • Proficiency in Python and SQL • Experience designing multi component high throughput experiments BENEFITS • Company-paid health/vision/dental benefits • Unlimited vacation and generous sick time • Company-sponsored meals and snacks • Wellness, caregiver and ergonomics benefits • 401(k) with company matching Mammoth Biosciences is harnessing the diversity of life to power the next generation of CRISPR products. Through the discovery and engineering of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to develop permanent genetic cures through best-in-class in vivo and ex vivo therapies and to democratize disease detection with on-demand diagnostics. Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Redmile Group, Foresite Capital, Senator Investment Group, Sixth Street, Decheng, Mayfield, NFX, and 8VC, along with leading individual investors including Brook Byers, Tim Cook, and Jeff Huber. TEAM Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need. It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation. Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law

We are looking for a part-time Bioinformatics Research Assistant to join our team. You will have the opportunity to work on a diverse set of initiatives led by the AllStripes research team, and will also contribute to cross-functional projects with our product, abstraction, and operations teams. You should love solving problems, working collaboratively, and working in research. What you’ll do... • Work with the research, product, and abstraction teams to develop and implement study protocols, track research study progress, assist with data quality control processes, and maintain our library of clinical data elements and surveys • Assist the research team with a variety of projects, including collaborative research programs, insights for the patient community, and new features on our two sided life sciences data platform • Support the development of relationships with key stakeholders in the rare disease space • Program all unstructured data studies and recommend improvements to increase efficiency and quality • Program all surveys and recommend improvements Who you are • A student enrolled in a graduate program in a biomedical science or clinical field (biomedical PhD or MS, MD, DO, genetic counseling, nurse practitioner or doctorate of nursing, PA, PharmD). • Past research experience (basic or clinical research) • Working knowledge of computer programming languages (R and/or SQL highly preferred) • Experience working collaboratively with others on long-term projects • Endlessly resourceful and self-motivated; you’re not afraid to dive into a complex problem • While hours will be flexible week to week, on average, be able to dedicate 10–20 hours per week to AllStripes (remotely). Most work can be completed on your own time. Contract will extend through June 2023, with the possibility of renewal. About the Hiring Manager: Caitlin Nichols - Research Director