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Bioinformatics Scientist (Clinical)


At Brooks, new ideas, new technologies and new ways of thinking are driving our future. Our customer-focused culture encourages employees to embrace innovation and challenge the status quo with novel thinking and collaborative work relationships. All we accomplish is grounded in our core values of Customer Focus, Achievement, Accountability, Teamwork, Employee Value and Integrity... Want to be part of a company whose goal is to be the best in the world and the best for the world? Apply today! GENEWIZ is seeking a Scientist II, Process Development to join our Next Generation Sequencing team. This position would have a strong focus on Bioinformatics. Responsibilities: • Leverage internal and external resources to develop, validate, implement new wet and dry lab NGS workflows, services, solutions, and platforms • Improve cost, efficiency, and performance of existing wet and dry lab workflows • Research new NGS workflows applicable to GENEWIZ customer base • Communicate project requirements, status, and deadlines with internal teams • Aid in developing Marketing materials and providing internal training to promote new services and solutions • Provide support to Operations team to deliver custom projects • Work with NGS Study Manager team to provide customers with pre-sale consultation and after-sale technical support Qualifications: • MS or PhD in Biological Sciences, required • Broad understanding of NGS required • Up to date on new NGS technologies including single cell RNA-seq, spatial transcriptomics and long read technologies (Pacbio, Oxford Nanopore) • Deep understanding oncology/immuno oncology preferred • Strong knowledge of next-generation sequencing, including wet and dry lab, required • Hands-on next-generation sequencing wet and dry lab experience, preferred • Strong track record of wet and/or dry lab assay development, required • Strong communication and interpersonal skills, both verbal and written • Ability to multitask and meet deadlines in a fast-paced, customer-oriented environment EOE M/F/Disabled/VET

Genome Bioinformatics Analyst

Pittsburgh, PA

• *Description** UPMC Presbyterian is hiring a Genome Bioinformatics Analyst to join the Molecular and Genomic Pathology Laboratory (MGP) team! This role will work a daylight schedule Monday through Friday. No weekends or holidays are required... The Molecular and Genomic Pathology Laboratory (MGP) is a dynamic state-of-the-art clinical laboratory that prides itself on providing the highest quality of patient care in the fields of inherited diseases, hematological malignancies, and solid tumors utilizing cutting-edge molecular testing platforms and informatics approaches exemplified by next-generation sequencing. MGP offers its staff a challenging and rewarding career by offering a wide variety of job responsibilities as well as opportunities to identify and build upon individual strengths. MGP promotes lab-wide collaboration and teamwork where each staff member is valued for the unique skill set they can offer the team. • *Purpose:** The Genome Bioinformatics Analyst works independently to curate disease, gene, and variant knowledge including variant interpretation, reporting, and consultation with laboratory staff, physicians, and genetic counselors. The analyst participates in clinical test development, validation, and maintenance of data analysis pipelines, monitoring of quality metrics, and the analysis of large datasets. This position is ideal for a post-doctoral candidate, who is interested in a career in clinical genomics and molecular diagnostics. • *Responsibilities:** + Designs and executes clinical validation studies to assess diagnostic test performance. + Curates disease, gene, and variant knowledge. + Helps implement curated knowledge, resources, and workflows into clinical operations. + Participates in developmental and clinical research projects, as needed. + Maintains SOP documentation of NGS bioinformatics pipeline. + In consultation with laboratory staff, physicians, and genetic counselors, participates in the review of patient results and develops interpretations for clinical reports. + Participates in clinical test development as needed. + Evaluates novel platforms and techniques in DNA sequencing, genotyping, and copy-number variation in order to assess suitability for diagnostic application. + Maintains data analysis pipelines, monitors quality metrics and analyzes data sets. • *Qualifications** + PhD in molecular biology, human genetics, bioinformatics, computational biology or related field. + MS degree may be considered with 2 or more years of relevant experience. + Strong experience with standard molecular genetics technologies and Next Generation Sequencing. + Familiarity with NGS datasets + Solid understanding of genetic variants within context of disease. + Familiarity with commonly used databases (HGMD, ExAC 1000 genomes), and bioinformatics tools (samtools, IGV, ANNOVAR, GATK) and file formats (BED, VCR, FASTQ, BAM) preferred. + Ability to search for and read literature related to detected variant significance. + Strong analytical and organizational skills. + Works effectively with interdisciplinary team scientists, physicians, genetic counselors. + Must demonstrate a high degree of professionalism, enthusiasm, and initiative on a daily basis. + Ability to work in a fast-paced environment. + Attention to detail is critical. • *Licensure, Certifications, and Clearances:** + Act 34 • *UPMC is an Equal Opportunity Employer/Disability/Veteran** REQNUMBER: 541204720

Staff Bioinformatics Scientist

West Menlo Park, CA

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science... to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit In this role, you will work with a team of talented scientists to develop state of the art assays to detect cancer signals at an early stage. You will be involved in the design of experiments, analysis of the raw data and interpretation of the results to improve assay performance. You will lead analytical efforts to characterize and improve assay attributes to make them more efficient and sensitive. You will also design and perform simulation studies to evaluate the effect of assay modifications on the classification results. You Will: • Act as a core member of the R&D team leading the analytical aspects of new assay development. • Support a team of assay scientists to characterize and evaluate assay performance. • Run in silico experiments to simulate assay modifications and characterize assay attributes. • Perform complex analysis of large genomic data sets. • Present project updates, data analysis, and experimental conclusions at technical meetings. Your Background Includes: • Master or PhD in computational biology, bioinformatics, statistics, biological sciences, cancer biology, genetics, genomics, computer science, physics, engineering, or equivalent preparation and experience. • In-depth knowledge of genomics, epigenetics, and Next Generation Sequencing workflows. • Preferred, 3 years of relevant experience in positions of increasing responsibility. • Demonstrated expertise in at least one programming language (R, Python, Go.) • Proficiency in Linux environment, version control tools, and reproducible research practices. • Proven knowledge of statistics. • Demonstrated ability to uncover new biological insights from large genomics datasets. • Effective written and verbal communication skills. • Ability to multitask as needed in a complex environment. GRAIL is an Equal Employment Office and Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, GRAIL has made the decision to require all U.S. employees receive the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation



Position: · Freelance... · Fully remote · Flexible schedule · No visa sponsorship available Qualifications: · PhD in computational biology/bioinformatics/computer science/mathematics, or related field · Minimum 4 years experience in bioinformatics · Experience in the analysis of large-scale omics data · Experience in machine learning or other modeling methods · Scripting in Python and/or R · English fluency

Research Assistant Professor - Bioinformatics Computational Core...

Tampa, FL

USF Genomics Program Research Assistant Professor and Bioinformatics Computational Core Services Director... The University of South Florida Genomics Program is seeking to hire a non-tenure earning Assistant Professor to conduct research, teach, and serve as the Bioinformatics Computational Core Services Director. The USF Genomics Program is a consortium of active genomics research programs from different colleges and campuses at USF. The USF Genomics Program projects integrate modern genomic approaches to understand and help develop solutions for some of the major challenges affecting global health and especially the Florida community. USF Genomics research projects are naturally interdisciplinary with studies that cross many boundaries of traditional scientific fields, integrating bioscience approaches in experimental and environmental research with computation biology. The USF Genomics Program is administratively housed in the USF College of Public Health and is physically located in the USF Interdisciplinary Research Building (IDRB) on the USF Tampa campus. The IDRB is a state-of-the art research facility which houses programs from Public Health, Medicine, Chemistry, and Engineering. The major role of the Bioinformatics Computational Core Services Director will be to manage computational support services for the USF Genomics Program sequencing core projects. In addition, as a member of the faculty in the College of Public Health, the incumbent will be expected to cover a minimum of 25% of annual salary through consulting services or committed time on individual research grants. In addition, the incumbent will be expected to teach and mentor students and career professionals, staff, and faculty in computational methods applied to genomics research. The incumbent will be located in the IDRB along with the USF Genomics Program Director and many of its researchers. The University of South Florida is a high-impact global research university dedicated to student success. Over the past 10 years, no other public university in the country has risen faster in the U.S. News and World Report’s national university rankings than USF. Serving more than 50,000 students on campuses in Tampa, St. Petersburg and Sarasota-Manatee, USF is designated as a Preeminent State Research University by the Florida Board of Governors, placing it in the most elite category among the state’s 12 public universities. USF has earned widespread national recognition for its success graduating under-represented minority and limited-income students at rates equal to or higher than white and higher income students. USF is a member of the American Athletic Conference. Learn more at USF Health’s mission is to envision and implement the future of health. It is the partnership of the USF Health Morsani College of Medicine, the College of Nursing, the College of Public Health, the Taneja College of Pharmacy, the School of Physical Therapy and Rehabilitation Sciences, the Biomedical Sciences Graduate and Postdoctoral Programs and USF Health’s multispecialty physicians group. For more information, visit The USF College of Public Health was founded in 1984 as the first college of public health in the State of Florida and is ranked as the highest public health degree program in Florida and number 20 nationally by the 2021 U.S. News and World Report. The College of Public Health consists of 241 faculty from multiple disciplines with regular, adjunct and collaborative appointments serving the educational needs of more than 4,600 students in bachelor’s, master’s and doctoral degree programs. The College is a recognized leader in online education, social marketing, community health, maternal and child health and global infectious disease research. The College offers multiple concentrations that lead to BSHS, BSPH, MHA, MPH, MSPH, DrPH, and PhD degrees, as well as several dual degrees, graduate certificates and online programs. Learn more at See directions below to access the USF Careers posting for position minimum and preferred qualifications. Closing Date: Positions will remain open until filled. Review of complete applications will begin February 11, 2022. Salary & Benefits: Nationally competitive salary with excellent benefits. To apply: Candidates must apply for each position separately in order to be considered for that position. Please visit and access “Work at USF” and then click on Access Careers@USF and search for Job Opening ID 29494. Documents to be uploaded with each application include a letter of application addressing the advertised minimum and preferred qualifications for the position to which applying, a CV and a list of three references. Review of application will not begin until all required documents are uploaded into Careers. References will not be contacted without notifying applicants in advance. According to Florida law, search records, including applications and search committee meetings, are open to the public. USF is an Equal Opportunity, Affirmative Action, and Equal Access institution. Applicants who need disability accommodations in order to participate in the selection process should notify Sheri Shakes at (813) 974-6494 or TDD (813) 974-1758 at least five working days in advance of need

Staff Bioinformatics Scientist - CTT

Brisbane, CA

Headquartered in Brisbane, CA, CareDx, Inc. is a leading precision medicine solutions company focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers. CareDx offers products, testing services and digital healthcare solutions along the pre- and post-transplant patient journey. It is the... leading provider of genomics-based information for transplant patients. Staff Bioinformatics Scientist - Cell Transplant Therapy As a member of Bioinformatics & Data Sciences group you will drive algorithm development and analysis of genomic NGS data for cell transplant therapy (CTT), primarily in oncology patients. In this role you will develop, launch, and innovate CTT products, QC, deployment, and improvement. You should have an excellent working knowledge of statistical principles and analytical methodologies relevant to high-throughput DNA sequencing data analysis. Your contributions will be foundational to the company’s mission of improving the lives of cell transplant therapy patients, including patients treated by CAR-T. Responsibilities include but are not limited to: • Drive research efforts to build advanced models for next generation sequencing algorithms and products • Collaborate with assay development scientists on design and development of novel assays and troubleshooting of existing products • Design and execute analysis plans to generate insights from large volumes of experimental data for improving assays and bioinformatics pipelines • Develop tools and automated analysis pipelines for clinical grade diagnostic tests • Provide written documentation and specifications • Collaborate with bioinformatics scientists, statisticians, LIMS engineers, CLIA lab scientists, clinicians • Mentor junior bioinformatics staff Qualifications: • Ph.D degree in bioinformatics, computer science, computational biology, mathematics, or related field • 5+ years’ experience with analysis of genomic NGS data using industry standard bioinformatics tools • Proficiency in computational analysis of genomic data, statistical principles, and modeling with focus on DNA-Seq • Proficiency with a high-level scripting language (Python/R/Java), experience in database query • Proficiency with bioinformatics best practices (e.g., version control, unit testing, code documentation/validation) • Immunotherapy and oncology background a plus • Regulated software design control experience a plus • Experience leveraging AWS based services (e.g., EC2, S3) to speed analyses a plus • A self-driven approach with an ability and desire to communicate to a non-technical audience how complex systems work and can be applied to complex data problems • A solid scientific foundation and familiarity with current literature • Proven excellent team player Additional Details: Every individual at CareDx has a direct impact on our collective mission to improve the lives of organ transplant patients worldwide. We believe in taking great care of our people, so they take even greater care of our patients. Our competitive Total Rewards package includes: • Competitive base salary and incentive compensation • Health and welfare benefits including a gym reimbursement program • 401(k) savings plan match • Employee Stock Purchase Plan • Pre-tax commuter benefits • And more! In addition, we have a Living Donor Employee Recovery Policy that allows up to 30 days of paid leave annually to a full-time employee who makes the selfless act of donating an organ or bone marrow. With products that are making a difference in the lives of transplant patients today and a promising pipeline for the future, it’s an exciting time to be part of the CareDx team. Join us in partnering with transplant patients to transform our future together. CareDx is an Equal Opportunity Employer and participates in the E-Verify program. • We do not accept resumes from headhunters, placement agencies, or other suppliers that have not signed a formal agreement with us

Lead Bioinformatics Scientist

Westlake, MD

We are currently searching for a Lead Bioinformatics Scientist to provide support services to satisfy the overall operational objectives of the NCI/CCR/Genetics Branch-OMICS Facility. Primary objective is to provide services and deliverables through performance of support services. This opportunity is full-time, and it is on site in Bethesda, MD. Duties & Responsibilities... • Collaborate with Genetics Branch PIs, biologists, clinicians, PI team based computational staff, and OMICS facility staff to understand their experimental and technical goals and suggest statistical and bioinformatics solutions for biological and translational questions such as mechanisms of oncogenesis, drug target discovery, drug mechanism elucidation and patient stratification efforts • Design and implement state-of-the-art computational methods; use existing open-source algorithms and develop custom algorithms to answer key cancer genomics questions using data from short Illumina and long-read multiple technologies whole genomics sequencing, short-read- Illumina and long-read PACBio whole transcriptome sequencing, single cell RNAseq, single cell ATACseq, ChipSeq, HiC, HiChiP, spatial transcriptomics, mass spec proteomics, immunopeptidomics, and spatial proteomics including CyTOF Imaging Mass Spectrometry and microarray data sets • Develop and implement codes to analyze histological images, spatial transcriptomic or pro-teomic and other digital imaging data • Provides programming and troubleshooting support to the Federal Government in the dissemination of research data. • Ensuring that Github is maintained for all codes developed by incumbent • Performs computations on research data analysis. • Participate in the optimization of the data life cycle for each project including the use of local and central archival storage, and the submission of mature datasets to the appropriate public databases • Updating codes to current versions on a 6 monthly basis and making and documenting improvements to the current codes • Integrating somatic mutations, translocations, amplifications, deletions, proteomics and epigenetics data into databases for visualization • Incorporate newly generated omics data sets in large-scale databases to support data-mining including integration with publicly available omics databases • Develop and implement machine learning including artificial and convolutional neural networks and other sophisticated algorithms • Works with staff on scientific programming and experimental design. • Work with GB collaborators • Work with staff on scientific programming and experimental design Prepare summaries and reports; attend meetings; present results and findings to staff • Records observations and report results at weekly laboratory meetings. • Reading and presentation of current literature relevant to current ongoing efforts • Collect reports • Provides statistical support / analysis on research data. • Provides research / service goals in the context of the laboratory's overall mission. • Evaluates new types of experimental approaches to protocols based on knowledge of scientific literature, available facilities and research needs. • Create generalizable code bases to improve and support development of pipelines for the analysis, interpretation and visualization of next-generation sequencing data Develop interactive shareable code solution using technologies like Jupyter KnitR for collaborators and actively maintain them in a centralized version controlled repository in Github • Independently coordinates the training of personnel in the use of scientific software applications, statistical software applications and programmatic software applications # SOAR Requirements Skills • Experience in leading/supervision of staff • Experience in working with Next Generation Sequencing Data • Familiarity with Genomics • Next gen sequencing data analysis: Bulk RNA-Sequencing • Cloud-Based Computing • Strong communications skills, both oral and written • Excellent analytical, organizational and time management skills • Single Cell RNA-Sequencing • Microarray data analysis • Working in Linux/Sever/Cloud environment. Qualifications • PhD in Biology, Life Sciences or a related discipline. • Minimum of four (4) years of experience in bioinformatics or computational biology or programming. Due to our contractual requirements and federal orders, including an Executive Order from the White House and an emergency regulation from the Centers for Medicare & Medicaid Services (CMS), the position for which you are applying requires that you provide proof of your vaccination status. If you are unable to receive the COVID-19 vaccine for medical reasons or because of a sincerely held religious belief, you may request an exemption from the vaccination requirement which shall be reviewed after the submission of requested documentation. If an accommodation is granted, the conditions may include weekly testing and masking. All Guidehouse employees also agree to follow any additional health and safety mitigation policies that may be required in the workplace. Company Description Dovel Technologies and its Family of Companies (Medical Science & Computing and Ace Info Solutions) were acquired in October 2021. Guidehouse is a leading global provider of consulting services to the public sector and commercial markets, with broad capabilities in management, technology, and risk consulting. By combining our public and private sector expertise, we help clients address their most complex challenges and navigate significant regulatory pressures focusing on transformational change, business resiliency, and technology-driven innovation. Across a range of advisory, consulting, outsourcing, and digital services, we create scalable, innovative solutions that help our clients outwit complexity and position them for future growth and success. The company has more than 12,000 professionals in over 50 locations globally. Guidehouse is a Veritas Capital portfolio company, led by seasoned professionals with proven and diverse expertise in traditional and emerging technologies, markets, and agenda-setting issues driving national and global economies. Guidehouse is an Equal Employment Opportunity / Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, national origin, ancestry, citizenship status, military status, protected veteran status, religion, creed, physical or mental disability, medical condition, marital status, sex, sexual orientation, gender, gender identity or expression, age, genetic information, or any other basis protected by law, ordinance, or regulation. Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance, including the Fair Chance Ordinance of Los Angeles and San Francisco. If you have visited our website for information about employment opportunities or to apply for a position, and you require accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse, and Guidehouse will not be obligated to pay a placement fee

Senior Bioinformatics Scientist II/ Staff Bioinformatics Scientist

Pleasanton, CA

Inscripta was founded in 2015 and recently launched the world's first benchtop Digital Genome Engineering platform. The company is growing aggressively, investing in its leadership, team, and technology with a recent $150mm financing round led by Fidelity and TRowe price. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and software, offers a fully automated... workflow that enables multiplexed, trackable editing of cells at an unprecedented scale. Inscripta’s mission is to enable scientists to realize the full potential of biology. Due to rapid growth and recent commercialization, Inscripta has an opening for a Senior Bioinformatics Scientist II/ Staff Bioinformatics Scientist in the Bioengineering Software Design team located in Pleasanton, CA or San Diego, CA or Boulder, CO or in the Remote U.S.. Summary: The Senior Bioinformatics Scientist II/ Staff Bioinformatics Scientist is a full-time individual-contributor position, to which you would devote all your professional effort. You will be a member of an incredibly talented interdisciplinary team, and your primary responsibility will be devoted to creating and improving library designs and library design tools needed to support Product Development and Commercial teams’ development of cells comprised of thousands of precise genomic edits. Come work with us to build the tools that will power a new era of genome engineering! Responsibilities: • Create design library orders to support our R&D Product Development and Commercial teams. • Develop, deploy, and train others to use new library design tools that help our Product Development team iterate through the design-build-test-learn cycle more quickly. • Work closely with applications scientists to document & codify library design best practices and strategies that leverage Inscripta’s technology platform. • Develop backend software to support our design library pipeline. This responsibility includes architecture decisions, feature augmentation, refactoring, testing, and documentation of code as well as participation in scrum team activities. • Such other matters as may be determined by yourself and the Company. Requirements • A Bachelor’s degree in a technical or scientific area. An advanced degree is strongly preferred. • A minimum of 7-10 years of experience (or equivalent with advanced degree). • Firm understanding of molecular biology, metabolic engineering, biophysics, and biochemistry is strongly preferred. • A strong working knowledge of bioinformatics file types like VCF, GB, GFF3, BED, and SAM/BAM. • Familiarity with bioinformatics databases like EcoCyc, UniProt, NCBI, Pfam, Rfam, YGD, ENSEMBL, UCSC genome browser. • A strong working knowledge of Python in OO setting and familiarity with packages like biopython, pandas, numpy, and scikit-learn. • Experience managing user interfaces such as Shiny (from RStudio) or Dash (from is a plus. • Software development skills, including a working knowledge of version control systems, continuous integration processes, and Agile development techniques – experience with Scrum is preferred. • Enthusiasm for developing software as part of a team is a must. • Patience and tenacity regarding working in a startup culture with a complex code base is a must. • 1+ years of experience writing production code in a team setting is preferred. • Energetic and motivated self-starter with excellent analytical, problem solving, communication, and presentation skills. • Special consideration will be given to candidates with expertise in synthetic biology, metabolic engineering, and advanced genome editing tools and methodologies. • Special consideration will be given to candidates with an excellent track-record of publications and/or other scientific achievements. Inscripta offers a competitive base salary, bonus plan, benefits package, 401k match, and an attractive equity program to all team members. Join us and work with a cutting edge organization creating cutting edge technology. At Inscripta, we don’t just accept difference — we celebrate it, support it, and thrive on it for the benefit of our employees, our innovation, and our community. We are proud to be an equal opportunity workplace because the more inclusive we are as a company, the better our work will be. Inscripta is headquartered in Boulder, CO with offices in Pleasanton and San Diego, CA. This position can work out of either our Pleasanton, CA or San Diego, CA or Boulder, CO locations, or work remotely in the U.S

Bioinformatics Specialist - Tu Lab

Dallas, TX

HHMI is currently seeking a talented Bioinformatics Specialist for a full-time opportunity to join the lab of Dr. Benjamin Tu at the University of Texas Southwestern Medical Center in Dallas, TX.The Tu lab is investigating how fundamental cellular processes are coordinated with metabolism and the metabolic state of the cell. They use the budding yeast Saccharomyces cerevisiae for many of their... studies to discover fundamental regulatory principles, but are also expanding some of their findings to mammalian systems. Their research has begun to show that small molecule metabolites play very underappreciated roles in the regulation of cell growth and homeostasis. The influence and importance of the metabolic state on cell regulation are far too often overlooked; the lab aims to decipher these very mechanisms. For more information about the Tu lab, please visit the Bioinformatics Specialist, you will be an enthusiastic problem solver who loves science and is excited to support research projects within the lab by working with experimental biologists to do custom analyses. You will have the unique opportunity to work with a diverse group of team members within the Tu lab, collaborate with other labs on UT Southwestern’s campus, and have the ability to contribute their efforts to several different research projects. The lab also has flexibility to allow for a hybrid (on-site/remote) work schedule. Essential Duties: Perform analyses of RNA-seq, ChIP-seq, and genome/exome sequencing datasets. Perform analyses of proteomics datasets and protein conservation/alignments. Work closely with experimental biologists in the lab to do custom analyses. Write custom code for analyses as needed. Perform appropriate statistical analyses. Preparation of data figures and visualization tools. Qualifications:EducationA master’s degree in bioinformatics, computational biology, computer science, biostatistics, or a closely related area is required.Experience A minimum of 2 years of experience with RNA-seq and ChIP-seq data analysis in a laboratory environment is required. Experience and skill with at least one programming language (for example: Python, R, Java, C++, etc.) is required. Experience with data visualization is strongly preferred. Knowledge, Skills, and Abilities Ability to communicate technical information to an audience not versed in bioinformatics and/or programming. Strong interest and enthusiasm for contributing to the lab’s research. Strong written and verbal communication skills. Strong organizational, time management, and prioritization skills. Strong sense of self-motivation with an ability to work well both independently and as part of a team. Ability to work on multiple projects simultaneously. Ability to interact positively with all team members at all levels and from all backgrounds. Ability to work efficiently, meet deadlines, and be adaptable to changing priorities. Application Instructions:Please attach the following information (preferably as a single PDF document) as part of your application. Résumé/CV emphasizing prior experience Contact information for three professional references Physical Requirements: Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis. Please Note: This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act

Bioinformatics Analyst I/II/III

Bar Harbor, ME

Summary The Carter Lab is seeking a Bioinformatics Analyst to join our research in the genetics and genomics of Alzheimer’s disease. This position will focus on using bioinformatics and computational biology analyses to formulate network-level therapeutic hypotheses to drive the development of new treatments. This analysis is a critical component of our goal to integrate diverse data resources... screen candidate compounds, and translate findings into preclinical tests using precision mouse models of disease. This work will be performed as part of two NIA-funded projects, the Emory/Sage/SGC TREAT-AD center ( and IU/Jax/Pitt MODEL-AD center (, that bring together researchers from more than a dozen institutions to develop new approaches to understanding and treating late-onset Alzheimer’s disease. These centers are components of a major open science initiative to understand and treat Alzheimer’s disease that includes the AMP-AD, ADNI, and ADSP research consortia. We are especially interested in candidates with systems biology expertise in model organisms who are seeking to apply their innovative ideas in a translational setting. The structure of TREAT-AD and MODEL-AD enable collaborative follow-up experimentation and refinement of computational hypotheses. We are dedicated to open science and establishing an inclusive culture to expand our vision of scientific progress. Responsibilities • Mining genome-scale data and interpreting results. • Performing statistical analysis, algorithm implementation, data visualization, and bioinformatics programming; packaging and interpreting results. • Developing novel computational strategies for big data integration. • Coordinating data analysis across multiple collaborating institutions. • Assisting in data dissemination. • Contributing to publications. • Level I Analyst duties include entry level statistical analysis, algorithm implementation, bioinformatics programming, running programs and packaging results. Evaluating data for quality assurance, and mining bioinformatics databases. Assisting development of requirements and testing for software/database systems. Tasks are complex, but the incumbent has support of immediate suppervisor or mentor for directional support during execution of work. • Level II Analyst duties include basic statistical analysis, algorithm implementation, bioinformatics programming, running programs and packaging and interpreting results. Conducting, analyzing, and interpreting quality assurance data. Mining bioinformatics databases and interpreting results. Developing requirements and test plans for software/database systems. Often receives tasks but requires attention from supervisor or mentor for additional directional support. • Level III duties include all the responsbilities of Level II Analyst but works more independently and provides more indepth analysis and interpretation of results. Level III Analysts act as mentor to junior level colleagues. They also presents materials at seminars and assists in research planning. Qualifications • Bioinformatics Analyst I: requires BS or MS degree in Bioinformatics or relevent biological sciences degree. Incumbents who have not achieved Masters degree may compensate for lack of a degree with at least five years of professional bioinformatics work experience. Works under close supervision. • Bioinformatics Analyst II requires MS or PhD degree in Bioinformatics or relevent biological sciences degree. Incumbents who have not achieved a Ph.D, may compensate with a Masters degree and at least five (5) years of professional work experience in bioinformatics. Works with limited supervision for tasks performed. • Bioinformatics Analyst III requires MS or PhD degree in Bioinformatics or relevent biological sciences degree. Incumbents who have not achieved the PhD level will have at least seven (7) years profession work experience in the bioinformatics domain. Incumbents with a PhD will have completed a bioinformatics postdoctoral fellowship and/or have a minimum of two years of professional work experience in the bioinformatics domain. • The ideal candidate will have experience in genetics and genomic analyses, with particular expertise in integrative analysis of transcriptomic, proteomic, metabolomic, and curated data. • Experience in Alzheimer’s disease research is preferred but not required. About JAX The Jackson Laboratory (JAX) is an independent, nonprofit biomedical research institution with more than 2,400 employees. Headquartered in Bar Harbor, Maine, it has a National Cancer Institute-designated Cancer Center in Augusta, Maine, a genomic medicine institute in Farmington, Connecticut, and facilities in Ellsworth, Maine, Sacramento, California, and Shanghai, China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine! EEO Statement The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws

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