Bioinformatics Jobs

Company Description Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum... Guardant Health has commercially launched Guardant360®, Guardant360 CDx, Guardant360 TissueNext™, Guardant360 Response™, and GuardantOMNI® tests for advanced stage cancer patients, and Guardant Reveal™ for early-stage cancer patients. The Guardant Health screening portfolio, including the Shield™ test, aims to address the needs of individuals eligible for cancer screening. Job Description Department Summary – This department works towards (NGS) Assay Workflow Software, Data Infrastructure, Data Research and Systems Integration. About the Role: This position is part of the Systems Integration team for an early-stage cancer screening NGS Assay and associated automation and bioinformatics software components. We are looking for a motivated scientist/engineer who is interested in crossing the bridge from academia to industry, in the near future and has either completed a grad program or is currently enrolled. This individual will get the opportunity to work at the forefront of scientific and technological innovation within an interdisciplinary Screening Systems Integration team and will make core contribution to evolving cancer screening products designed to have clinical impact on patients. Come join us! Essential Duties and Responsibilities: • Analyze large amounts of data on NGS assay performance and generate visualizations for storytelling, monitoring and tracking • Assess various fundamental calculations in assay and associated software implementation • Generate test methods for assessing assay and software calculations in Python • Generate data visualization to assess the performance of the assay and various assay Quality Controls (in Python). • Generate reports integrated in python notebooks, that include data visualization and Quality Control calculations. • Once the project is completed, provide written documentation and requirements related to Assay, Software and Automation. • Present findings and results to cross functional highly technical audience in Bioinformatics, Software, Automation and Assay functions. • Contribute to a highly collaborative work environment among cross functional teams. Qualifications • Completed or currently enrolled in a MS or PhD program in Biomedical Sciences, Engineering, Software or Bioinformatics. • Significant research experience in these areas. • Proficiency in Python, including visualization packages such as Matplotlib and Plotly • Ability to work with large amounts of structured or semi-structured data. • Ability to build reproducible and well-written Python code for data analytics • Ability to communicate highly technical findings to a diverse audience, within NGS assays development teams. Preferred ​​Qualifications: • Experience with analysis of NGS assay data. Additional Information Hybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients. Covid Vaccination Policy: Guardant Health requires all employees to be fully vaccinated. We follow the CDC guidelines for the definition of “fully vaccinated”, meaning an employee is consider fully vaccinated against COVID-19 after receiving the second dose of a two-dose vaccine or one dose of a single-dose vaccination, and necessary booster vaccines. In addition, fully vaccinated employees will be required to maintain their fully vaccinated status under this policy by obtaining, if applicable, any FDA-approved boosters. Candidates may request and obtain an approved exemption from Guardant’s COVID-19 U.S. Vaccination Policy as a reasonable accommodation, as consistent with applicable laws.  Candidates will not be able to start their employment with Guardant until they show proof of vaccination or have an approved exemption. For positions based in Palo Alto, CA or Redwood City, CA, the hourly range for this full-time position is Undergraduate $27/hr., Graduate $32/hr., and Doctorate $40/hr. The range does not include benefits and, if applicable, overtime, bonus, commission, or equity. Within the range, individual pay is determined by work location and additional factors, including, but not limited to, job-related skills, experience, and relevant education or training. If you are selected to move forward, the recruiting team will provide details specific to the factors above. Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time. Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. All your information will be kept confidential according to EEO guidelines. To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants. Please visit our career page at: http://www.guardanthealth.com/jobs/ #LI-CS4

Bioinformatics Analyst I Job ID: req3397... Employee Type: exempt full-time Division: Bioinformatics and Computational Science Facility: Frederick: Ft Detrick Location: PO Box B, Frederick, MD 21702 USA The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way. PROGRAM DESCRIPTION The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases. The Bioinformatics and Computational Science (BACS) Directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of bioinformatics and computational science by developing and applying world-leading computing technologies to basic and applied biomedical research challenges, data science, supporting critical operations, developing and delivering national data resources, and utilizing leading-edge software. The Advanced Biomedical and Computational Science (ABCS) group is a part of BACS and serves as a hub of translational scientists with expertise in machine learning applied to the interpretation of 2D and 3D biomedical images, clinical and genomics integration, computational chemistry, protein modeling, bioinformatic analysis of omics data, and other applications of computational and data science. ABCS develops state-of-the-art technologies in large-scale data modeling, analysis, and integration and supports the scientific research at the Frederick National Lab by helping translate scientific questions to technical solutions for cancer and biomedical research. KEY ROLES/RESPONSIBILITIES • Work independently and with management to design and develop software applications including application architectures and data modeling • Define metadata templates for data sharing of biological assay data • Performs documentation, coding, debugging, testing and troubleshooting throughout the application development lifecycle process • Work independently and with management to define requirements, tasks and timelines • Develop and maintain program code in adherence with established coding standards • Develop and enhance UI designs and architectures • Assist in creating and management of technical documentation • Report project status regularly to management • Manage and maintain code repository • Monitor application day-to-day performance and perform program tuning as needed • Other duties as required BASIS QUALIFICATIONS To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below: • Possession of a Bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) or 4 years of relevant experience in lieu of degree • Foreign degrees must be evaluated for U.S. equivalency • Self-starter, motivated toward success • Experience working in a scientific environment with bench scientists and programming experts • Experience designing, developing and delivering dynamic web systems; HTML/HTML5, PHP, Python (or equivalent server-side language), MySQL, MVC, CSS, OOP, JavaScript • Demonstrated web page design programming experience using a combination of HTML, HTML5, CSS, Java, Ajax and JavaScript • Ability to identify and resolve cross browser and cross platform compatibility/connectivity issues • Experience with MySQL and/or other relational database management systems • Solid Understanding of OOP (Object-Oriented Programming), the model/view/controller (MVC) pattern of application programming • Experience developing web-based application front ends utilizing valid HTML, cascading style sheets (CSS), and JavaScript • Experience with open-source libraries/frameworks such as Laravel, jQuery and Bootstrap • Knowledge of biomedical methodologies and experimental assays • Ability to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Candidates with these desired skills will be given preferential consideration: • Knowledge of Section 508 accessibility and compliance requirements • Experience developing Specifications/Wireframes • Experience in implementation of workflows management systems • Experience in project planning and project life cycle methodology • Experience in Unit Testing and/or CI/CD • Experience using subversion/GIT EXPECTED COMPETENCIES • Self-starter, motivated toward success • Experience designing, developing and delivering Web 2.0 systems; HTML/HTML5, SQL, MVC, CSS, OOP, JavaScript • Demonstrated web page design programming experience using a combination of HTML, HTML5, CSS, Ajax and JavaScript • Working knowledge of SQL • Ability to identify and resolve cross browser and cross platform compatibility/connectivity issues Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW) #readytowork

Job Description The Future Talent Program features internships that last up to 12 weeks and will include one or more projects. These opportunities in our Global Support Functions Division can provide you with great development and a chance to see if we are the right company for your long-term goals... We are seeking a highly motivated intern to join the Bioinformatics Team in Data Science & Scientific Informatics at Our Company. The intern will evaluate, develop, and optimize computational methods to analyze next-generation sequencing datasets in support of Our Company’s drug discovery and development programs, and will produce bioinformatics pipelines that can be operated on high-performance computing clusters and in the cloud. The intern will collaborate with biologists and data analysts in one or more diverse therapeutic areas in Our Company's Research Laboratories, such as: • Oncology • Immunology • Infectious Diseases & Vaccines • Neuroscience • Pharmacokinetics Applicants should indicate in their cover letters which of these therapeutic areas are preferable. This will be an opportunity to apply cutting edge data science techniques to emerging fields with exciting and impactful applications in drug discovery and development. The applicant should be able to work full-time for 10-12 weeks in the summer of 2023. Required Education & Experience: • Candidates must have a bachelor’s degree in computational biology, bioinformatics, or a related field • Candidates must have be pursuing a master’s degree or doctorate in computational biology, bioinformatics, or a related field. Exceptional undergraduate candidates who can demonstrate strong technical capabilities are also encouraged to apply • Candidates must have experience analyzing next-generation sequencing datasets, such as WGS, WES, RNA-seq, ChIP-seq, ATAC-seq, and single-cell applications • Candidates must have experience evaluating computational methods for common applications, such as alignment, assembly, variant detection, genome enrichment, and phylogenetics • Candidates must have familiarity with common bioinformatics file formats (FASTA, FASTQ, BAM, VCF, etc.) • Candidates must have proficiency in programming languages (e.g., Python, R, C++) in a Unix/Linux environment • Candidates must have experience with high-performance Linux clusters and cloud computing • Candidates must have experience leveraging online resources (software manuals, GitHub, Stack Overflow) to troubleshoot • Candidates must have excellent interpersonal and team skills • Candidates must have excellent verbal and written communication skills in English Preferred Experience & Skills: • Candidates should have experience in applying and optimizing machine learning tools • Candidates should have experience with a pipeline scripting language such as Nextflow • Candidates should have experience with containers (Docker, Singularity) Our Support Functions deliver services and make recommendations about ways to enhance our workplace and the culture of our organization. Our Support Functions include HR, Finance, Information Technology, Legal, Procurement, Administration, Facilities and Security. Who we are… We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world. What we look for… Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today. FTP2023 Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission. Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. For more information about personal rights under Equal Employment Opportunity, visit: EEOC Know Your Rights EEOC GINA Supplement​ Pay Transparency Nondiscrimination We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace. Residents of Colorado: Click here to request this role’s pay range. Learn more about your rights, including under California, Colorado and other US State Acts Search Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Intern/Co-op (Fixed Term) Relocation: No relocation VISA Sponsorship: No Travel Requirements: Flexible Work Arrangements: On-Site Shift: Valid Driving License: Hazardous Material(s): Requisition ID:R229039

Why Mayo Clinic Mayo Clinic is the nation's best hospital (U.S. News & World Report, 2022-2023) and ranked #1 in more specialties than any other care provider. We have a vast array of opportunities ranging from Nursing, Clinical, to Finance, IT, Administrative, Research and Support Services to name a few. Across all locations, you’ll find career opportunities that support diversity, equity and... inclusion. At Mayo Clinic, we invest in you with opportunities for growth and development and our benefits and compensation package are highly competitive. We invite you to be a part of our team where you’ll discover a culture of teamwork, professionalism, mutual respect, and most importantly, a life-changing career! Mayo Clinic offers a variety of employee benefits. For additional information please visit Mayo Clinic Benefits. Eligibility may vary. Position description Under general supervision and guidance: - The analyst/programmer is responsible for the support of moderately complex software-based systems in the supported areas. - Contributes to the design, development, implementation, and maintenance of custom software, or the installation and maintenance of purchased software systems. - Produces documentation such as systems requirements, designs, and plans as requested by the work unit leadership. - Work will be reviewed for quality, timeliness, and adequacy at predetermined milestones. Qualifications Working towards a PhD in Computer Science or related Informatics field with a GPA of 3.0 or greater. Additional qualifications Previous work experience or course work in artificial intelligence and machine learning and use of software packages for data management and statistical analysis is preferred. Experience in coding with Python, R, Java, C++ or other programming languages, along with Linux/UNIX operating systems preferred. Exemption status Non-exempt Compensation Detail This position has a predetermined rate of $24.42 or $30.00 per hour. Benefits eligible Yes Schedule Full Time Hours / Pay period 80 Schedule details Monday-Friday Weekend schedule N/A Remote No International Assignment No Site description Mayo Clinic is located in the heart of downtown Rochester, Minnesota, a vibrant, friendly city that provides a highly livable environment for more than 34,000 Mayo staff and students. The city is consistently ranked among the best places to live in the United States because of its affordable cost of living, healthy lifestyle, excellent school systems and exceptionally high quality of life. Recruiter Stephanie Baird EOE As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available

Payroll Title: BIOINFORMATICS PROGR 2 Department: PSYCHIATRY/Genetic/Bioinformatics Hiring Pay Scale... $30.17 - $38.32 / Hour Worksite: Campus Appointment Type: Career Appointment Percent: 100% Union: Uncovered Total Openings: 4 Work Schedule: Days, 8 hrs/day, Monday-Friday #119126 Bioinformatics Programmer II - Hybrid/Remote Extended Deadline: Thu 3/9/2023 Apply Now UC San Diego values equity, diversity, and inclusion. If you are interested in being part of our team, possess the needed licensure and certifications, and feel that you have most of the qualifications and/or transferable skills for a job opening, we strongly encourage you to apply. For the safety and well-being of the entire university community, the University of California requires, with few exceptions, that all students, faculty and staff be vaccinated against the COVID-19 virus and influenza before they will be allowed on campus or in a facility or office. For more information visit: Flu Vaccine Mandate / COVID Vaccine Policy This position will remain open until a successful candidate has been identified. UCSD Layoff from Career Appointment: Apply by 10/03/2022 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor. Special Selection Applicants: Apply by 10/13/2022. Eligible Special Selection clients should contact their Disability Counselor for assistance. This position will work a hybrid schedule which includes a combination of working both onsite on Campus and remote. Placement within the range is determined by internal equity, relevant qualifications, and collective bargaining agreements (when applicable). DESCRIPTION UCSD Department of Psychiatry is one of the most innovative and productive academic departments in the country, offering challenging career opportunities in the diverse areas of advanced educational programs, cutting-edge research, and state-of-the-art clinical services. The department is committed to offering a dynamic learning environment and growing opportunities to its talented and dedicated employees. Under general supervision, the incumbent will be working as a Bioinformatics Programmer 2 performing research in psychiatric genetics in humans and across species (rats, mice, zebrafish etc.) within the Department of Psychiatry. The primary focus area of this position is within a National Institute of Health project aimed at developing tools for cross-species translation. The applicant will also be involved in large-scale genetic studies aimed at elucidating the genetic basis of psychiatric disorders. The incumbent will perform genetic analyses of complex traits, build systems for data organization, design computational pipelines for genetic analyses, and develop tools for genomics research. This includes pipelines based on the established computations workflow, using Bash scripting and software such as PLINK, GCTA, LDSC, PRS-CS/PRSice/LDPred, PrediXcan, GEMMA, SAIGE and network analyses; performing routine quality control for data inputs and analysis outputs, assisting with data organization and backup. The incumbent will also participate in discussion and planning meetings, study existing research and suggest approaches for building developing tools for cross-species genomic integration and conducting large scale genetic analyses of complex traits and write sections on data analysis for the manuscripts, progress reports and proposals. Additional responsibility will include developing new pipelines, which require selecting software and testing different computational approaches. The successful applicant will have exceptional written and verbal communication, will carefully document their work and annotate their code. Excellent organization skills are required in order to work as part of a team. MINIMUM QUALIFICATIONS • Six (6) years of related experience, education/training, OR a Bachelor’s degree in related area plus two (2) years of related experience/training. • Working knowledge of bioinformatics methods and data structures. • Working knowledge of applications programming and web development. • Working knowledge of databases. • Working project management skills. • Working knowledge of modern biology. • Effective interpersonal skills in order to work with both technical and non-technical personnel at various levels in the organization. • Working knowledge of application and data security concepts. • Demonstrated experience in handling big data sets. • Experience in programming languages, including R, Python, and Bash script. • Demonstrated knowledge of Linux-based workflow development, including Bash scripting, High Performance Computing, cloud technologies such as Amazon EC2. • Experience performing genetic analyses using software such as TWAS/PrediXcan, PRS-CS/PRSice/LDPred, LDSC, PLINK, GCTA. • Experience performing routine quality control for genetic data using statistical analysis with software such as Plink. • Experience to study existing research and suggest approaches for building developing tools for cross-species genomic integration and conducting large scale genetic analyses of complex traits. • Proven ability to effectively manage time and see assigned parts of projects through to completion on deadline. Demonstrated experience in using software revision control systems (e.g. GIT). Proven ability to carefully document the work and annotate the code. • Strong communication skills. Ability to communicate technical information in a clear and concise manner. • Proven ability to write sections on data analysis for the manuscripts, progress reports and proposals. • Demonstrated knowledge of genetic analysis software such as GEMMA, GTCA, SAIGE. • Demonstrated knowledge of transcriptomic-related software such as PrediXcan. • Ability to use PostgreSQL queries to maintain, update and retrieve data from the custom database. SPECIAL CONDITIONS • Employment is subject to a criminal background check. • Must be able to work weekends and overtime as needed. Pay Transparency Act Annual Full Pay Range: $59,700 - $124,300 (will be prorated if the appointment percentage is less than 100%) Hourly Equivalent: $28.59 - $59.53 Factors in determining the appropriate compensation for a role include experience, skills, knowledge, abilities, education, licensure and certifications, and other business and organizational needs. The Hiring Pay Scale referenced in the job posting is the budgeted salary or hourly range that the University reasonably expects to pay for this position. The Annual Full Pay Range may be broader than what the University anticipates to pay for this position, based on internal equity, budget, and collective bargaining agreements (when applicable). Apply Now Job offer is contingent on successful engagement in the UC COVID-19 Vaccination program (fully vaccinated with documented proof or approved exception/deferral). If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable. UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team! Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached. To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community. UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see: http://www-hr.ucsd.edu/saa/nondiscr.html UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information. UC San Diego Health maintains a marijuana and drug free environment. Employees may be subject to drug screening

We are looking for an intelligent, hard-working, and dynamic individual to join Bioinformatics and Molecular Data group, a subdivision of the Dana-Farber Cancer Institute (DFCI) Informatics and Analytics Department. The group encompasses expertise in bioinformatics, machine learning, and computational biology and works with some of the most prominent research and clinical DFCI programs, from... basic research to translational research to clinical diagnostics and operations. We are looking to hire a Bioinformatics Scientist (Level I, II, III) Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The successful candidate will be responsible for managing and independently executing complex bioinformatics tasks: • Working with leading DFCI scientists on designing and executing key biomedical projects, providing expertise in bioinformatics and computational biology. • Owning and leading various projects, delivering results and generating relevant reports. • Collecting, analyzing, interpreting, and integrating complex biomedical data. • Contributing expertise to DFCI software code base and relevant communities of practice. • Working as part of a broader team to identify and implement long term computational solutions to address unmet needs of DFCI investigators. • Improving quality, speed and efficiency of current resources through evaluating and benchmarking new software tools and pipeline development. • Integrating the developed bioinformatics tools and workflows into DFCI cloud-based resources. • Advanced degree, Master's or PhD (preferred), in a relevant filed with evidence of impact in application of bioinformatics or computational biology to real life problems, ideally within a biomedical research or clinical environment. • Bioinformatics skills at the interface between bioinformatics programming and understanding of biological and/or clinical problems, especially as related to the next generation sequencing data analysis (bulk and single cell RNA-seq, DNA-seq, ChIP-seq, Cut&Run, etc). • Experience with cloud-based computing and workflow implementation (WDL, CWL, NextFlow). • Knowledge in one or more areas of cancer research, including solid tumors, hematologic malignancies, patient-derived cancer models, biomarker discovery, ctDNA detection and analysis, etc. is a major plus. At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply

Description Job Description... Leidos Public Health Division is seeking a Bioinformatics Developer to support public health projects. The ideal candidate will have demonstrated experience in Next Generation Sequencing (NGS) data analysis including development and application of quality control, assembly, functional annotation, sequence alignment, variant detection, and phylogenetic analyses of viral, bacterial, fungal, and microbial, eukaryote genomes, transcriptomes and metagenomes. This position is open to telecommuting, with Atlanta location preferred. Responsibilities • Develop, test, and deploy bioinformatics data pipelines and workflows using open-source technologies such as Nextflow, Snakemake, or similar workflow management systems • Develop and execute bioinformatics algorithms and workflows in high-performance computing environments, including cloud and hybrid-cloud execution environments • Write custom scripts and software to perform bioinformatics analysis using Python, Perl, Shell (Bash), R and/or Java • Perform analysis of biological data using open-source bioinformatics tools as well as licensed proprietary software such as CLC Genomics Workbench and Geneious. Support modeling and simulation of evolutionary and population biological process using Bayesian inference and/or genetic algorithms • Use statistical analysis tools, interpret, and communicate results • Provide support for approaches, processes, and methods for the management, integration, analysis, and visualization of data from disparate data sources • Develop tools for visualizing complex biological datasets and able to interpret and communicate results as well as uncertainty to a diverse group of customers • Develop and maintain highly curated genomic sequence databases, signature databases for virulence and AMR markers, strain type and pathogen type markers • Work together with the DevOps team in adopting best software engineering practices for tool and workflow development • Adapt bioinformatics algorithms and workflows in high-performance computing environments, including cloud and hybrid-cloud execution environments • Provide guidance and support in scaled data analysis and management of next generation metagenomic sequencing data • Assist with developing standard operating procedures for bioinformatics analyses • Assist in the development and maintenance of specialized, high-performance databases for different aspects of *omics analysis, including relational databases such as PostgreSQL, MySQL/MemSQL/MariaDB, and Microsoft SQL Server for data integration; NoSQL-based databases, such as MongoDB, for high-volume, unformatted data sets; and custom, binary databases such as BLASTDB for hardware-accelerated and conventional BLAST searches • Collaborate with external and internal subject matter experts identified above to develop, implement, and maintain novel data science analytic workflows and connectivity to various existing data science analytic workflows used for downstream processing of genomic assemblies and relevant metadata. Additionally, this might require the development of internal application programming interfaces (APIs) and API calls to external databases • Perform statistical analyses using R, Python, and/or other open-source or commercial statistical applications, as required • The contractor shall work with team members to develop schemes and methods for visualizing complex scientific datasets using Tableau, SpotFire, ggplot, D3, R, Circos, Processing, etc. • Supports researchers in creating and submitting publication and poster presentations • Communicate progress orally and in writing with our scientific community stakeholders • Assist with preparation of reports, presentations, and papers for publication in scientific journals, conferences, and meetings • Conduct bioinformatics trainings. MINIMUM QUALIFICATIONS: • A Bachelor’s or Master’s degree in bioinformatics, genomics, molecular biology, genetics or related field • 2+ years of bioinformatics experience • Experience with processing of high-throughput data and possessing strong data management and analysis skills, particularly in relation to microbial genomics analyses • Experience working in Linux environments and broad experience with open-source bioinformatics tools • Proficient in coding/scripting in Python, R, Perl, Shell (Bash), or similar language • Experience working in a high-performance computing and/or cloud computing environment • Competency writing customs scripts and software to perform bioinformatics analysis using Python, Perl, R and/or Java • Strong communication skills • Ability to obtain NACI clearance. Position requires US Citizenship or US Permanent Residency Status and the ability to obtain a Public Trust Clearance. PREFERRED QUALIFICATIONS: • 2-5 years of bioinformatics experience • Experience in designing and conducting training workshops to the bioinformatics community on latest bioinformatics methods and concepts • Experience working with Nextflow (preferred), Snakemake, or similar workflow management systems • Experience in one or more of the following phylogenetic analysis and visualization tools is highly desirable: BEAST, FastTree, RaxML, MrBayes, NextStrain, Microreact hhscdc Pay Range: Pay Range $63,050.00 - $97,000.00 - $130,950.00 The Leidos pay range for this job level is a general guideline only and not a guarantee of compensation or salary. Additional factors considered in extending an offer include (but are not limited to) responsibilities of the job, education, experience, knowledge, skills, and abilities, as well as internal equity, alignment with market data, applicable bargaining agreement (if any), or other law. #Remote

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time... molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.  Position  As a Bioinformatics Intern, you will develop novel bioinformatics analysis tools to assist Eikon’s drug-discovery efforts, possible areas of focus including cell-line engineering, genomics, and other “omics” applications (e.g., transcriptomics).  About You  You are interested in pursuing a career in cutting edge bioinformatics. You have a passion for developing bioinformatic workflows and a desire to understand all the data involved. You are conscientious and value scientific reproducibility and intelligibility as much as innovation. What You’ll Do  Carryout novel Bioinformatics analysis Build reproducible analysis pipelines using off the shelf and custom software Collaborate with biologists and chemists to translate needs into working solutions   Qualifications  Currently enrolled in a graduate program in Bioinformatics, Computer Science, Computational Biology or similar field Strong expertise in scientific python (e.g., pandas, scipy, matplotlib)  Experience with current NGS data Expertise in data workflow management systems (e.g., Snakemake, Nextflow) a plus  Excellent verbal and written communication skills  Enthusiasm for gaining biological and drug discovery experience essential  The expected hourly range for this role is $35.00 to $42.00 per hour depending on skills, competency and the market demand for your expertise

Bioinformatics Analyst I, Biostatistics Branch, CGR - Hybrid Remote/Onsite Job ID: req3372... Employee Type: exempt full-time Division: Clinical Research Program Facility: Rockville: 9609 MedCtrDr Location: 9609 Medical Center Dr, Rockville, MD 20850 USA The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way. PROGRAM DESCRIPTION The Cancer Genomics Research (CGR) laboratory in Gaithersburg, MD, is an advanced, fast-paced, high-throughput organization dedicated to the support of molecular, genetic and epidemiologic studies for investigators at the National Cancer Institute's Division of Cancer Epidemiology & Genetics (DCEG). The Division includes over 70 principal investigators (PIs) who are at the forefront in cancer epidemiology, genetics, and biostatistics and conduct sophisticated multidisciplinary family- and population-based research utilizing cutting-edge multi-omics technologies to discover the genetic and environmental determinants of cancer. The investigators at DCEG are uniquely positioned to design exemplary studies by collaborating with investigators globally and lead the design and analysis of large-scale genome-wide association studies, studies of tumor characteristics using integrated genomic data analysis and molecular epidemiologic studies based on novel metabolomic and macrobiotic assays. Within DCEG, the Biostatistics Branch (BB) staff and Investigators develop statistical methods and data resources to strengthen observational studies, intervention trials, and laboratory investigations of cancer. DCEG/BB is adding computational support, to be provided through CGR, to support methods for large genomic studies including GWAS analysis, somatic mutation analysis, and integrative tumor analysis. We are seeking a highly motivated bioinformatics analyst to join the bioinformatics team at the CGR and provide dedicated analytical support for BB investigators while working in concert with DCEG investigators, external collaborators, CGR management and staff. The successful incumbent will provide support to the BB analytical efforts, and will have the opportunity to: KEY ROLES/RESPONSIBILITIES • Work closely and learn from expert principal investigators (PIs) within the Biostatistics Branch while supporting a broad portfolio of DCEG projects • Utilize strong programming expertise to learn, test, benchmark and apply new software packages in a high-performance computing cluster (HPC) and/or cloud environment. • Review, QC, and integrate data from multiple sources (multi-omics studies), primarily focused on germline genotyping and sequencing data, with some additional somatic mutations, copy number alterations, transcription, and methylation data for cancers. • Organize results into clear presentations and concise summaries of work, in formats useful for scientific interpretation • Document all analyses and pipelines clearly using collaborative tools and share with teams in support of reproducible and FAIR research • Work closely with DCEG and BB PIs and senior bioinformaticians in support of scientific manuscript development, submission, revision activities with significant co-authorship opportunities BASIC QUALIFICATIONS To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below: • Possession of a Bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) in bioinformatics, computer science, computational biology, biostatistics or related field. Additional qualifying experience may be substituted for the required education • Foreign degrees must be evaluated for U.S. equivalency • The ability to construct practical computational pipelines for data parsing, quality control and analysis for large-scale genetic or genomics datasets • Strong programming skills (e.g., in R, Python) • Demonstrable shell scripting skills (e.g., bash, awk, sed) • Experience working in a Linux environment (especially a HPC environment or cloud) • Ability to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Candidates with these desired skills will be given preferential consideration: • Strong programming skills in Python, R and Bash scripting with experience working on HPC • Candidates with bioinformatics/computer/biostatistics science background or strong programing skills and interest in biology are highly encouraged to apply • Experience with various environment/dependency management tools (e.g., pip, venv, conda, renv) • Knowledge of DevOps tools and technologies, such as Docker/Singularity, GitHub for code management; submission of a public GitHub or GitLab portfolio is strongly encouraged • Hands-on experience in processing sequencing, genotyping, expression, and other data utilizing bioinformatics tools is preferred but not required • Ability to multi-task in a fast-paced environment, organize and execute multiple projects in parallel both independently and as part of working groups • Flexibility to understand the needs of the investigators and switch gears based on project requirements • Basic familiarity with public genomic tools, databases, and utilities • Experience managing large datasets and computational tasks • Team oriented with demonstrated ability to self-educate in current bioinformatics techniques and resources • Excellent written and oral skills to communicate clearly and effectively with researchers from diverse backgrounds Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW) #readytowork

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds... and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. • Interprets complex biological information. Performs tasks to reduce and consolidate output from software. Prepares data for utilization by other scientists. • Monitors new data from public databases, finds and loads missed data, cleans loaded data to satisfy quality control criteria. • Must be able to query various sources for the information needed; i.e., the Web, publications and internal DFCI resources. • Directs and guides DNA, RNA and protein sequence database searches and the computational analysis of resulting data. • Implements end-users needs in database searching and integration. • Maintains the computational infrastructure and controls the flow of samples and information for large-scale studies. • Recognizes and reports problems with the data management process and fixes the problems whenever possible. • Bachelors degree required, MS preferred or PhD in bioinformatics, computer science and/or the life sciences and 0-2 years relevant experience. • Familiarity with simple programming using Perl/Python or Java, C/C++, statistical programming using R or related tools, web-development, and database query through SQL. • Familiarity with principles of experimental design and modern data analysis paradigms is required. • Strong interpersonal skills and ability to effectively interact with all levels of staff and external contacts. • Excellent analytical, organizational and time management skills. At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law