Bioinformatics Jobs

HOW MIGHT YOU DEFY IMAGINATION? You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10... million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role. Scientist - RNA Bioinformatics Live What you will do Let’s do this. Let’s change the world. We are actively seeking a highly qualified and motivated Scientist with a strong background in RNA bioinformatics. The scientist will join the Bioinformatics Technology team within Amgen’s Center for Research Acceleration by Digital Innovation (CRADI). CRADI is a multi-disciplinary effort embedded within our drug discovery engine that continually uses advancement in digital technologies for disease modeling and digital modality engineering to accelerate our pipeline from target inception through drug development. Bioinformatics Technologies plays a pivotal role within CRADI’s Computational Biology and Bioinformatics function, establishing an innovation engine for deploying and exploiting emerging digital technologies in the field of computational biology. RNA therapeutics comprise a rapidly expanding class of modalities that will fast-track solutions to the clinic. In this vital role you will lead the development and implementation of AI/ML models and optimization paradigms for the design of best-in-class RNA therapeutics. This position will involve close collaborative relationships with scientists within RNA therapeutic research, safety sciences, and therapeutic areas as well as data scientists and engineering partners across Amgen R&D. An ability to communicate clearly and collaborate effectively with colleagues from different fields will be essential. The successful candidate will possess strong analytical proficiency, have a high degree of technical competency in computational sciences with a deep theoretical understanding of machine learning paired with excellent understanding of RNA biology proven by a strong track record of innovative and collaborative research published through peer-reviewed publications. RESPONSIBILITIES: • Engage in collaborative efforts with stakeholders and subject matter experts to formulate technical solutions accelerating the development and increasing clinical efficacy of RNA therapeutic modalities • Find opportunities, set strategy, and deliver appropriate quantitative methods, such as discriminative and generative AI/ML models, to push the state of the art for optimizing RNA therapeutic modality design, formulation, and delivery • Consult on data generation and translate experimental findings into computational model design and refinement • Serve as subject matter expert on the intersection of computer science and RNA biology • Clearly document methods and analyses to allow reproducible research • Collaborate with engineers and data scientists to develop innovative bioinformatics tools that facilitate data access, model utilization, and output interpretation • Communicate project results and data-driven recommendations to stakeholders and cross-functional partners • Monitor, review, and critically interpret published computational research spanning RNA therapeutics and emerging oligonucleotide modalities • Proactively scope and deploy novel computational methods and digital technologies Win What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications. Basic Qualifications: Doctorate degree Or Master’s degree and 4 years of computational biology, bioinformatics, biomedical data science or related field Or Bachelor’s degree and 6 years of computational biology, bioinformatics, biomedical data science or related field Preferred Qualifications: • PhD in computer science, data science, computational biology or bioinformatics including industry experience • Deep experience in and theoretical understanding of statistical modeling, machine learning, deep learning, and other relevant quantitative methods • Knowledge in RNA biology, particularly RNA structure and function • Fluency in scientific programming and tool development with R, Python, or equivalents. Proficiency in C++ or Java is a plus. • Proven record of innovative thinking to propose and champion the development of novel algorithms and AI/ML models that generated interpretable and actionable results for practical applications • Experience with software development good practices, including code versioning, documentation, and testing, amongst others • Experience with cloud computing • Creative, open-minded, and passionate about scientific research • Demonstrated ability to thrive in a team environment • Strong interpersonal, collaborative, organizational, and presentation skills • Understanding of RNA therapeutic modality discovery and development is a plus Thrive What you can expect of us As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. The annual base salary range for this opportunity in the U.S. is $135,563 - $150,625. In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan • Stock-based long-term incentives • Award-winning time-off plans and bi-annual company-wide shutdowns • Flexible work models, including remote work arrangements, where possible Apply now for a career that defies imagination Objects in your future are closer than they appear. Join us. careers.amgen.com Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancers, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation

Bioinformatics Analyst I Job ID: req3397... Employee Type: exempt full-time Division: Bioinformatics and Computational Science Facility: Frederick: Ft Detrick Location: PO Box B, Frederick, MD 21702 USA The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way. PROGRAM DESCRIPTION The Frederick National Laboratory is dedicated to improving human health through the discovery and innovation in the biomedical sciences, focusing on cancer, AIDS and emerging infectious diseases. The Bioinformatics and Computational Science (BACS) Directorate works collaboratively and helps to fulfill the mission of Frederick National Laboratory in the areas of bioinformatics and computational science by developing and applying world-leading computing technologies to basic and applied biomedical research challenges, data science, supporting critical operations, developing and delivering national data resources, and utilizing leading-edge software. The Advanced Biomedical and Computational Science (ABCS) group is a part of BACS and serves as a hub of translational scientists with expertise in machine learning applied to the interpretation of 2D and 3D biomedical images, clinical and genomics integration, computational chemistry, protein modeling, bioinformatic analysis of omics data, and other applications of computational and data science. ABCS develops state-of-the-art technologies in large-scale data modeling, analysis, and integration and supports the scientific research at the Frederick National Lab by helping translate scientific questions to technical solutions for cancer and biomedical research. KEY ROLES/RESPONSIBILITIES • Work independently and with management to design and develop software applications including application architectures and data modeling • Define metadata templates for data sharing of biological assay data • Performs documentation, coding, debugging, testing and troubleshooting throughout the application development lifecycle process • Work independently and with management to define requirements, tasks and timelines • Develop and maintain program code in adherence with established coding standards • Develop and enhance UI designs and architectures • Assist in creating and management of technical documentation • Report project status regularly to management • Manage and maintain code repository • Monitor application day-to-day performance and perform program tuning as needed • Other duties as required BASIS QUALIFICATIONS To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below: • Possession of a Bachelor's degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) or 4 years of relevant experience in lieu of degree • Foreign degrees must be evaluated for U.S. equivalency • Self-starter, motivated toward success • Experience working in a scientific environment with bench scientists and programming experts • Experience designing, developing and delivering dynamic web systems; HTML/HTML5, PHP, Python (or equivalent server-side language), MySQL, MVC, CSS, OOP, JavaScript • Demonstrated web page design programming experience using a combination of HTML, HTML5, CSS, Java, Ajax and JavaScript • Ability to identify and resolve cross browser and cross platform compatibility/connectivity issues • Experience with MySQL and/or other relational database management systems • Solid Understanding of OOP (Object-Oriented Programming), the model/view/controller (MVC) pattern of application programming • Experience developing web-based application front ends utilizing valid HTML, cascading style sheets (CSS), and JavaScript • Experience with open-source libraries/frameworks such as Laravel, jQuery and Bootstrap • Knowledge of biomedical methodologies and experimental assays • Ability to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Candidates with these desired skills will be given preferential consideration: • Knowledge of Section 508 accessibility and compliance requirements • Experience developing Specifications/Wireframes • Experience in implementation of workflows management systems • Experience in project planning and project life cycle methodology • Experience in Unit Testing and/or CI/CD • Experience using subversion/GIT EXPECTED COMPETENCIES • Self-starter, motivated toward success • Experience designing, developing and delivering Web 2.0 systems; HTML/HTML5, SQL, MVC, CSS, OOP, JavaScript • Demonstrated web page design programming experience using a combination of HTML, HTML5, CSS, Ajax and JavaScript • Working knowledge of SQL • Ability to identify and resolve cross browser and cross platform compatibility/connectivity issues Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW) #readytowork

Company Description Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum... Guardant Health has commercially launched Guardant360®, Guardant360 CDx, Guardant360 TissueNext™, Guardant360 Response™, and GuardantOMNI® tests for advanced stage cancer patients, and Guardant Reveal™ for early-stage cancer patients. The Guardant Health screening portfolio, including the Shield™ test, aims to address the needs of individuals eligible for cancer screening. Job Description The Bioinformatics, BioPharma team at Guardant Health is focused on partnerships with leading biotech and pharma companies who are at the forefront of cancer therapeutics and diagnostics. In this role, you will help lead the bioinformatics and data analysis in support of the late-stage oncology products and other emerging technologies. You will work with a number of BioPharma and clinical customers, tailor personalized analyses for each organization, and tackle some of the most interesting biological and technical questions related to cancer diagnostics and therapy selection. You will contribute to BioPharma project initiatives in-house, including development of novel bioinformatic and analytical methods. As a part of the Bioinformatics and BioPharma teams, you will have the opportunity to innovate and implement your ideas to continuously improve our oncology products and analytics to adapt to the changing landscape of BioPharma needs. You will work closely with multiple teams across Guardant Health, including Bioinformatics, Medical Affairs, Software, Business Development, Technology Development, and Operations. You will gain first-hand experience working with experts in each of these areas to accomplish projects related to Guardant Health’s BioPharma business. You will work together with our collaborators in industry, hospitals and academia on high-impact translational research and publish on your findings. You will have access to the unprecedented compendium of data collected at Guardant Health and you will be able to (and should be excited to!) leverage this data for tumor biology and technological insights. Qualifications • PhD in bioinformatics, genomics or related fields with 2-3 years of experience • Extensive knowledge of molecular biology and cancer genomics • Expertise in scripting language – R and/or Python and linux shell environment (Bonus: experience developing novel / custom algorithms for interpretation of NGS data) • Excellent data analysis skills and working knowledge of statistical methods • Experience with NGS data and landscape of bioinformatics tools (Bonus: direct experience with epigenomic data) • Desire and ability to dig deeply through various data types to seek out answers • Great communication and presentation skills, ability to present clearly and effectively to stakeholders across organizations • Ability to work well in a fast-paced startup environment, delivering high-quality results under tight timelines • Ability to synthesize high-level concepts, drive projects forward, while maintaining attention to detail • Strong team player: ability to work together with your team as well as cross-functionally and even across institutions, to accomplish your goals Additional Information Hybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients. For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $124,240 to $168,000. The range does not include benefits, and if applicable, bonus, commission, or equity. The US base salary range for this full-time position is $86,968 to $134,400. The range does not include benefits, and if applicable, bonus, commission, or equity. The range displayed reflects the minimum and maximum target for new hire salaries across all US locations for the posted role. Within the range, individual pay is determined by work location and additional factors, including, but not limited to, job-related skills, experience, and relevant education or training. If you are selected to move forward, the recruiting team will provide details specific to the factors above. Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time. Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability. All your information will be kept confidential according to EEO guidelines. To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants. Please visit our career page at: http://www.guardanthealth.com/jobs

Description Expected Starting Salary Range: 27.60 - 35.28... SUBFUNCTION DEFINITION: Bioinformatics applies biology, computer science, data science, and statistics to analyze and interpret biological and clinical data. REPRESENTATIVE RESPONSIBILITIES • Management and "wrangling" of genomic data. • Help manage Xenopus genomes and participate in genome annotation and gene nomenclature. • Perform gene orthology and genomic synteny analysis. • Help test newly developed code and provide feedback for developers. • Work with biocurators and developers on the technical specification of new features for the website. • Participate in data analysis and development of new ways to visualize data. • Help manage data exports for public use and data exchange with other databases (e.g., NCBI, UniProt). • Co-author reports and publications and give presentations at national and international meetings and workshops. •Informatics Curates, annotates and organizes various types of biomedical data (e.g., genomic, clinical, imaging, sequencing) in various formats (e.g., flat files, relational and non-relational databases). Collects and records appropriate metadata. Ensures data are securely stored yet highly accessible to authorized users. •Data Analysis Executes pipelines for curating, processing and analyzing biomedical data of various types (e.g., genomic, clinical, imaging, sequencing). Utilizes existing software to support complex data management tasks (e.g., sequence alignment, variant calling, inter-sample comparison, patient matching/linkage). Utilizes web-based bioinformatics tools and public/proprietary relational databases. Follows standard operating procedures. Works in collaboration with both technology and scientific teams. •Requirements Gathering Interfaces with clinicians/researchers to collect requirements of basic to moderate complexity including user workflows. Contributes to problem-solving and solution evaluation. •Software Evaluation & Development Contributes to the evaluation and development of software solutions to support basic to moderately complex data workflows. Under general supervision, assists with implementation and testing efforts. Effectively communicates the status of all efforts to necessary parties. Utilizes project and time management skills to complete projects within specific timeframes. •Publication Contributes to analyses and publications. Generates reports and figures for publications. Assists with materials for publications and scientific meetings. Works closely with biostaticians on the production of publication and presentation materials. Qualifications EDUCATION/EXPERIENCE Required: •Bachelor's degree in Bioinformatics and Genomics or related degree • 0 - 2 years of work experience in a related job discipline Preferred: • MSc or PhD degree in bioinformatics and genomics. • Experience working with genomic data • Experience with a programming language such Python • Experience with standard bioinformatic tools, analyses, and file formats (Genome Browsers, JBrowse, BLAST, BLAT, multi-sequence alignments, GFF, GTF, etc). • Strong interpersonal and communication skills, including excellent written and spoken English. • Demonstrated experience documenting code, pipelines and workflows • Demonstrated ability to work in a team as well as independently, efficiently (i.e., both quickly and accurately) • Preference will be given to an applicant with: • Experience with other genomic databases • Experience in relational databases, data annotation/biocuration. • Experience in analyzing genomics data, using genome browsers and common bioinformatics tools. • Experience with Git based version control, particularly GitLab, and continuous integration. • Experience in constructing and maintaining bioinformatic pipelines. Cincinnati Children's is proud to be an Equal Opportunity Employer that values and treasures Diversity, Equity, and Inclusion. We are committed to creating an environment of dignity and respect for all our employees, patients, and families (EEO/AA

Summary: Under the general supervision... of the Bioinformatics Scientist Department Manager Laboratory Directors and Pathologists and in accordance with established policies and procedures the Bioinformatics Analyst performs independently in the Department of Pathology. The Bioinformatics Analyst will be responsible for analyzing clinical Next Generation Sequencing data contributing to the development of data analysis pipelines and organizing and maintaining databases. Responsibilities: Participates in the daily clinical bioinformatics workflow such as DNA-seq and RNA-seq data analysis. Analyzes the clinical data for the validation of new Next Generation Sequencing tests. Assists with preparation of validation summaries of the new Next Generation Sequencing tests. Assists in developing analysis pipelines for Next Generation Sequencing tests. Evaluates analytical aspects of emerging analysis methods. Assists in the development of databases and webtools. Other information: BASIC KNOWLEDGE: Bachelor s Degree required. Master s Degree in Bioinformatics Computational Biology Computer Science or a related field is preferred. Demonstrates strong scientific understanding of genomics. Demonstrates proficiency in programming and scripting skills (e.g Perl Python or Java). Demonstrates knowledge of DNA-seq and RNA-seq data analysis tools (e.g. BWA GATK STAR Samtools). Demonstrates knowledge of database and webtool development (e.g. SQL HTML CSS Apache). Maintains up-to-date knowledge of bioinformatics data analysis tools Familiarity with CAP/CLIA lab setting is preferred but not required. EXPERIENCE: At least two years of industry or clinical lab experience. Experience in developing computational approaches for cancer genome and/or germline analysis is highly desirable. Excellent teamwork time management and organizational skills. WORK ENVIRONMENT AND PHYSICAL REQUIREMENTS: This position requires the Bioinformatics Analyst to work closely with Bioinformatics Scientists Medical Technologists Management Laboratory Directors and Pathologists. Ability to operate equipment and instruments and to perform all procedures within assigned laboratory section and interpret them for accuracy. Physical and visual dexterity necessary to conduct and interpret analysis. Visual strain is encountered while closely examining data. INDEPENDENT ACTION: Ability to work independently in a fast-paced multidisciplinary environment. Ability to multi-task and work on multiple clinical and developmental projects simultaneously. Analyst functions independently within the department s policies and procedures. Refers specific complex issues to the Bioinformatics Scientist Manager Laboratory Directors or Pathologists when clarification of policies and procedures is required. SUPERVISORY RESPONSIBILITY: None. Lifespan is an Equal Opportunity / Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race color religion sex national origin age ethnicity sexual orientation ancestry genetics gender identity or expression disability protected veteran or marital status. Lifespan is a VEVRAA Federal Contractor. Location: Rhode Island Hospital USA:RI:Providence Work Type: Full Time Shift: Shift 1 Union: Non-Union

The primary purpose of the Research Bioinformatician position is to carry out data preparation responsibilities related to cancer clinical trials, develop skilled statistical programs, perform statistical analysis associated with clinical data and prepare written reports to investigators. In addition, this position prepares statistical considerations for basic trial designs or grants and performs... biostatistical reviews of protocols. KEY FUNCTION: • Statistical Consulting and Collaboration: • Compiles, analyzes and reports statistical data for various projects including, but not limited to manual and computer-aided data abstraction and evaluation, clinical trials, computerized imaging and bioinformatics. • Prepares statistical considerations for basic trial designs and carries out uncomplicated statistical analyses independently, but completes statistical responsibilities for more complex projects with supervision. • Assists faculty in the development of new statistical methodology for measurement and analysis of data. • Applies advanced statistical methods, simulation models, and skilled statistical programming as needed. • Assesses relevant literature as well as existing data, evaluates the quality of data used in reports and assists with preparation and distribution of data for committee and scientific meetings. • Attends project meetings with collaborators with or without supervisor as directed by supervisor. • May present findings at relevant meetings both inside and outside of the institution as requested. • Protocol Review: • Participates in the protocol review process jointly with supervisor. • Statistical Reporting: • Prepares written reports to investigators jointly with supervisor. • May present findings at relevant meetings both inside and outside of the institution as requested. • Other duties as assigned. EDUCATION: Required: Master's degree in Biostatistics, Statistics, Bioinformatics, Mathematics or related field. Preferred: PhD in Biostatistics, Statistics, Bioinformatics, Mathematics or related field. EXPERIENCE: Required: Two years experience with mainframe and/or PC databases, document processing and statistical software such as SAS and S-Plus. With preferred degree, no required experience. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html Additional Information • Requisition ID: 147658 • Employment Status: Full-Time • Employee Status: Regular • Work Week: Days • Minimum Salary: US Dollar (USD) 81,000 • Midpoint Salary: US Dollar (USD) 101,500 • Maximum Salary : US Dollar (USD) 122,000 • FLSA: exempt and not eligible for overtime pay • Fund Type: Soft • Work Location: Remote (within Texas only) • Pivotal Position: Yes • Science Jobs: Yes #LI-Remote

Job Summary: The UW-Madison Department of Bacteriology (https://bact.wisc.edu) seeks to hire a Research Cyberinfrastructure Specialist to support expanding computational microbiology research in our department. The research enterprise in the Department of Bacteriology encompasses premier research laboratories and facilities with missions to explore fundamental and complex questions in... microbiology, microbial ecology, and virology. The Research Cyberinfrastructure Specialist will advance the development and use of high-performance shared computing systems supporting diverse computational research in the Department of Bacteriology. This Research Cyberinfrastructure Specialist position reports to Dr. Karthik Anantharaman, and works closely with the faculty, staff, and members of the Department of Bacteriology. Responsibilities: Applies computational, computer science, data science, and cyber infrastructure (CI) research and development principles to provide advanced and varied consultation on research and technology integration and development. Provides non-routine maintenance, planning, and advanced troubleshooting to ensure CI resources meet research needs. Provides guidance and training to other staff and serves as subject matter expert for internal stakeholders. • 25% Serves as a CI domain expert, provides direct support of users, other staff providing support of users, and advanced computing systems • 25% Provides expertise and experience in CI to lead troubleshooting, analysis, operation, and support of advanced computing systems and for research • 35% Develops unique and custom Cyber Infrastructure solutions for research needs • 10% Writes and updates documentation and tutorials supporting CI activities for research. May provide brief courses for internal researchers and external collaborators • 5% Provides consultation and expertise for research proposals. May act as technical lead for cyber infrastructure projects. May serve as Co-Principal Investigator for a proposal Tasks: • Work with faculty, students and other researchers to understand their research needs and assist in experimental design and development of highly complex research methodologies that use high-throughput computing/bioinformatics. • Works with supervisor to set time committed to different research groups, maintains a record of the individuals who have been helped and the training or research outcomes • Analysis, operation, and troubleshooting of computational bioinformatics research • Promote and advocate the use of shared campus computational resources (such as CHTC) amongst researchers. • Provide assistance in interfacing with shared campus computational resources and enable training of researchers. • Assist researchers in integrating shared campus computational resources into their extramural grant applications. • Conduct assessments of continuous improvement. Continue to look for areas of improvement, research then develop processes, and then document/communication/train on those new processes. Institutional Statement on Diversity: Diversity is a source of strength, creativity, and innovation for UW-Madison. We value the contributions of each person and respect the profound ways their identity, culture, background, experience, status, abilities, and opinion enrich the university community. We commit ourselves to the pursuit of excellence in teaching, research, outreach, and diversity as inextricably linked goals. The University of Wisconsin-Madison fulfills its public mission by creating a welcoming and inclusive community for people from every background - people who as students, faculty, and staff serve Wisconsin and the world. For more information on diversity and inclusion on campus, please visit: Diversity and Inclusion Education: Required Master's Degree Advanced degree in the biological sciences with a demonstrated track-record of bioinformatics/computational biology research (evidenced, for example, through peer-reviewed publications) Qualifications: - Advanced degree preferred in the biological sciences with a demonstrated track-record of bioinformatics/computational biology research - Bioinformatics experience in a broad array of areas, such as sequence analysis, protein analysis, metabolomics, etc. - Familiarity with Unix-based systems and demonstrated ability to code in at least one language (e.g. Perl, Python, etc). - Must be able to work constructively in a group setting Additional skills desired for the position: - Evidence of multi-disciplinary research collaboration across different fields of biology - Experience with high-throughput computing - Strong organization skills, evidence of independence, attention to detail, and ability to interact and manage a wide diversity of projects and researchers (faculty, students, technicians, etc). Work Type: Full Time: 100% Onsite with potential to migrate to hybrid in the future Appointment Type, Duration: Ongoing/Renewable Salary: Minimum $63,800 ANNUAL (12 months) Depending on Qualifications Additional Information: - The UW-Madison College of Agricultural and Life Sciences is committed to maintaining and growing a culture that embraces diversity, inclusion and equity, believing that these values are foundational elements of our excellence and fundamental components of a positive and enriching learning and working environment for all students, faculty and staff. At CALS, we acknowledge that bias, prejudice, racism, and hate have historically occurred in many forms that cause significant and lasting harm to members of our community. We commit to taking actions each day toward a college that is inclusive and welcoming to all. - A criminal background check will be conducted prior to hiring. - A period of evaluation will be required. How to Apply: Please click on the "Apply Now" button to begin the application process. The applicant tracking system will require that you either log in or create an account. Be prepared to upload ONE PDF document containing: 1) a current resume/CV; 2) a cover letter briefly describing your qualifications relative to this position as well as your vision for the position; and 3) Contact information for three (3) professional references, including at least one current or former supervisor. Contact: Karthik Anantharaman karthik@bact.wisc.edu 608-265-4637 Relay Access (WTRS): 7-1-1. See RELAY_SERVICE for further information. Official Title: Research CI Spec II(RE074) Department(s): A07-COL OF AG & LIFE SCIENCES/BACTERIOLOGY Employment Class: Academic Staff-Renewable Job Number: 278282-AS The University of Wisconsin-Madison is an Equal Opportunity and Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to, including but not limited to, race, color, religion, sex, sexual orientation, gender identity, national origin, age, pregnancy, disability, or status as a protected veteran and other bases as defined by federal regulations and UW System policies. We promote excellence through diversity and encourage all qualified individuals to apply. If you need to request an accommodation because of a disability, you can find information about how to make a request at the following website: https://employeedisabilities.wisc.edu/disability-accommodation-information-for-applicants/ Employment will require a criminal background check. It will also require you and your references to answer questions regarding sexual violence and sexual harassment. The University of Wisconsin System will not reveal the identities of applicants who request confidentiality in writing, except that the identity of the successful candidate will be released. See Wis. Stat. sec. 19.36(7). The Annual Security and Fire Safety Report contains current campus safety and disciplinary policies, crime statistics for the previous 3 calendar years, and on-campus student housing fire safety policies and fire statistics for the previous 3 calendar years. UW-Madison will provide a paper copy upon request; please contact the University of Wisconsin Police Department

Overview The Department of Hematology at St. Jude Children’s Research Hospital is seeking a highly motivated Senior Bioinformatics Analyst to join our research team focused on exploring the genetics of sickle cell disease. While sickle cell disease is a monogenic disorder, clinical outcomes vary across affected individuals, at least in part due to other genetic factors, many of which are yet to... be discovered. The Senior Bioinformatics Analyst will have the opportunity to contribute to many projects aimed at elucidating the genetic etiology of sickle cell disease-related outcomes, including project conception, data analysis, and manuscript preparation. Specific responsibilities may include developing, evaluating, and/or implementing analytic, data visualization, and statistical approaches for genomics analyses. We are seeking candidates with expertise in identifying factors that modify disease risk or progression, treatment responsiveness, or survivorship. Candidates with a strong background in statistical genetics, genetic epidemiology, or bioinformatics are highly encouraged to apply for this position. Excellent communication skills are essential. Our group is multidisciplinary, with collaborations across departments within St. Jude Children’s Research Hospital, including the Center for Applied Bioinformatics and the Department of Biostatistics, allowing for cross-training and mentorship opportunities. As part of the Sickle Cell Clinical Research & Intervention Program, our group has access to rich longitudinal phenotypic data, and we have several ongoing and potential projects to examine the association between genetic variation and various clinical outcomes, including pain, renal function, cognitive function. This position will also have access to state-of-the-art High Performance Computing systems. Additionally, there will be opportunity for collaboration with external scientists, as we are part of a multi-institutional effort to evaluate the genetics of sickle cell disease, including assessing germline genetic factors as well as characterizing the prevalence and consequence of clonal hematopoiesis (acquired somatic mutations) in individuals with sickle cell disease. Responsibilities • Collaborate with scientists across and outside the institution to develop and test hypotheses regarding the genetic modifiers of sickle cell disease. • Analyze genetic data with minimal supervision by performing advanced analysis, including quality control, data visualization, and statistical evaluation. • Assist with project reports, presentations to diverse audiences, and manuscripts of analysis results. • Participate in the development and implementation of procedures to obtain new datasets. • Stay current on literature and routinely evaluate and integrate new analytical tools. Minimum Education • Bachelor's degree in bioinformatics, cheminformatics, statistics/computer science (with a background in biological sciences or chemistry) or related field. • Master's degree preferred. Minimum Experience • Minimum Requirement: 4+ years of relevant experience required. • Experience Exception: Master's degree and 1+ years of relevant experience. • Experience in at least one programming or scripting language and at least one statistical package, with R preferred. Other Information St. Jude is an Equal Opportunity EmployerNo Search Firms: St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.COVID-19 vaccine: St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment. 50685

OPPORTUNITY Mammoth Biosciences is seeking a Bioinformatics Scientist II to join its growing team. The successful candidate will contribute towards Mammoth’s efforts to develop safe and effective therapeutic treatments for genetic diseases. The Scientist II, Bioinformatics will work closely with researchers, development teams and external partners to establish statistical analysis tools, help... design assays and produce insights on the effects of our novel CRISPR systems. The scientist will also interact closely with the computational team to define and use internal tooling. KEY RESPONSIBILITIES • Design statistical analysis pipelines for multi-omics data • Work closely with the platform team to help optimize our novel CRISPR system • Communicate solutions to a team of software and data engineers • Organize and present data in internal and external meetings • Other duties as assigned REQUIRED QUALIFICATIONS • PhD with 1+ years of experience, MS with 4+ years of experience, or BS with 6+ years of experience in Computer Science, Bioinformatics, Computational Biology, Biostatistics, or a related field • Experience in developing bioinformatic pipelines • Proficiency in Python • Proficiency in SQL • Experience using a digital LIMS system PREFERRED QUALIFICATIONS • Experience modeling lab assays with LIMS system, preferably using Benchling • Experience analyzing CRISPR related assays • Experience communicating and visualizing results to computational and scientific teams • Proficiency in R • Experience working with cloud resources in AWS • Experience working with workflow management systems (Prefect, Airflow, Nextflow) • Experience writing code in a production environment (CI/CD, testing) BENEFITS • Company-paid health/vision/dental benefits • Unlimited vacation and generous sick time • Company-sponsored meals and snacks • Wellness, caregiver and ergonomics benefits • 401(k) with company matching Salary Range: $127,946 - $147,000 The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region. Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies. It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation. Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law

Summary: Under the general supervision... of the Bioinformatics Scientist Department Manager Laboratory Directors and Pathologists and in accordance with established policies and procedures the Bioinformatics Analyst performs independently in the Department of Pathology. The Bioinformatics Analyst will be responsible for analyzing clinical Next Generation Sequencing data contributing to the development of data analysis pipelines and organizing and maintaining databases. Responsibilities: Participates in the daily clinical bioinformatics workflow such as DNA-seq and RNA-seq data analysis. Analyzes the clinical data for the validation of new Next Generation Sequencing tests. Assists with preparation of validation summaries of the new Next Generation Sequencing tests. Assists in developing analysis pipelines for Next Generation Sequencing tests. Evaluates analytical aspects of emerging analysis methods. Assists in the development of databases and webtools. Other information: BASIC KNOWLEDGE: Bachelor s Degree required. Master s Degree in Bioinformatics Computational Biology Computer Science or a related field is preferred. Demonstrates strong scientific understanding of genomics. Demonstrates proficiency in programming and scripting skills (e.g Perl Python or Java). Demonstrates knowledge of DNA-seq and RNA-seq data analysis tools (e.g. BWA GATK STAR Samtools). Demonstrates knowledge of database and webtool development (e.g. SQL HTML CSS Apache). Maintains up-to-date knowledge of bioinformatics data analysis tools Familiarity with CAP/CLIA lab setting is preferred but not required. EXPERIENCE: At least two years of industry or clinical lab experience. Experience in developing computational approaches for cancer genome and/or germline analysis is highly desirable. Excellent teamwork time management and organizational skills. WORK ENVIRONMENT AND PHYSICAL REQUIREMENTS: This position requires the Bioinformatics Analyst to work closely with Bioinformatics Scientists Medical Technologists Management Laboratory Directors and Pathologists. Ability to operate equipment and instruments and to perform all procedures within assigned laboratory section and interpret them for accuracy. Physical and visual dexterity necessary to conduct and interpret analysis. Visual strain is encountered while closely examining data. INDEPENDENT ACTION: Ability to work independently in a fast-paced multidisciplinary environment. Ability to multi-task and work on multiple clinical and developmental projects simultaneously. Analyst functions independently within the department s policies and procedures. Refers specific complex issues to the Bioinformatics Scientist Manager Laboratory Directors or Pathologists when clarification of policies and procedures is required. SUPERVISORY RESPONSIBILITY: None. Lifespan is an Equal Opportunity / Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race color religion sex national origin age ethnicity sexual orientation ancestry genetics gender identity or expression disability protected veteran or marital status. Lifespan is a VEVRAA Federal Contractor. Location: Rhode Island Hospital USA:RI:Providence Work Type: Full Time Shift: Shift 1 Union: Non-Union