Bioinformatics Jobs

Aspen Neuroscience is seeking an Executive Director of Bioinformatics with a passion for shaping and influencing both research and clinical products across the entire portfolio for Aspen's bioinformatics solutions. The ideal candidate has excellent team leadership and communication skills and a drive for delivering innovative bioinformatics-based analysis solutions across a broad range of use... cases including (1) quality control testing throughout GMP manufacturing of cellular therapy product; (2) product release; and (3) genetic disease and cancer screening to support clinical studies. This new role requires a proven track record in establishing a strategic roadmap for innovations across bioinformatic methods and algorithms, delivering continuous improvements in core analysis capabilities, establishing information delivering system, and working with internal stakeholders and KOLs. DUTIES AND RESPONSIBILITIES: • Lead the bioinformatics development organization, including the delivery of novel methods, algorithms, and analysis pipelines. • Bioinformatic method and algorithm development to further support product characterization and therapeutic potency evaluation. • Drive improvements in speed, accuracy, and precision, as well as the expansion of applications, features, and functions which enable access to broader market segments. • Support the design, delivery, and validation of both research and clinical bioinformatic pipelines across a wide range of applications including basic research, biopsy evaluation and biomarker discovery. • Lead development of statistical and computational methods to analyze large-scale, multi-omic data. • Leverage resources to support clinical assay development through analytical design validation and external trial support. • Provide strategic thinking and leadership related to a wide range of applications and systems. • Help deliver, refine, and communicate the vision of the next generation of informatics to the rest of the organization. • Works closely with the business and other technology teams to define the roadmap and drive execution. • Create an environment of ingenuity and creativity, and act as a role model for others in challenging the status quo to encourage innovation. • Drive change across processes, practices, and technology within the organization by building a high caliber team that can deliver effectively. • Minimize schedule and technical risk by foreseeing and addressing obstacles proactively and aggressively; leverage past experience and communication skills to collaborate effectively and cross-functionally. • Investigate new methodologies, technologies, and experimentation which might progress Aspen's strategic objectives. • Build relationships with external customers, partners, and key opinion leaders and represent Aspen externally as a thought leader in bioinformatics. Education and Experience: • PhD in computer science, bioinformatics, statistics, or related mathematics or scientific field • A minimum of 15 years of algorithm and informatics product development experience in a complex systems environment • Extensive experience in bioinformatics analysis across genome, exome, and genotyping data. • Direct experience working on regulated or clinically validated products strongly preferred. • 12+ years of leadership experience including globally distributed teams and director-level direct reports. Job Specifications: • A senior level leader who has led centralized software and informatics product development organizations in a high growth environment. • Must be capable of balancing regulatory requirements with agile software delivery, with the ability drive process improvements throughout the organization. • Possesses a collaborative, yet relentless approach to process improvement and team management to achieve best in class results, especially around cost, cycle time / throughput and customer service. • Proven track record of partnering with R&D, Manufacturing and Quality, and Clinical Teams to optimize new product launches and product lifecycle management within a fast-paced, high growth company with a robust pipeline of new products and short product lifecycles. • Positive and dynamic management style, combined with superior communication skills and high credibility; able to gain followership and attain buy-in from internal stakeholders; capable of successfully navigating a complex organizational matrix. • A fast learner and decisive leader with a quick mind, sound judgment, and excellent problem solving / critical thinking skills EEO and Employment Eligibility Aspen Neuroscience is committed to providing equal employment opportunities to all employees and job applicants and prohibits discrimination and harassment of any type. We are committed to creating an inclusive environment for all employees. Total Rewards and Culture Aspen Neuroscience, Inc., located in scenic Torrey Pines, is noted for its collaborative, and learning focused culture where each person is valued for contributing their strengths and energy to building a world-class line of products for patients in need. The company offers a competitive total compensation package, time-off in addition to Company observed holidays, Medical/Dental insurance benefits, gym membership, and other wellness perks

Are you ready to take your Bioinformatics skills to the next level and join a company that thrives on Discovery? If yes, I have the perfect position for you! Imagine a world where you could detect health issues sooner to treat them more effectively. Where food and water are always safe, even in remote corners of the earth. And where scientific and medical research are enhanced to solve the... greatest challenges of our times. At PerkinElmer, we imagine this world every day. Then, we innovate and collaborate to make it happen everywhere. Our dedicated team of about 16,000 employees worldwide, pioneers scientific technologies for better detection, imaging, and informatics to help our customers work to create healthier families, improve the quality of life, and sustain the well-being and longevity of people globally. If you are seeking a meaningful, impactful, and stimulating career, look no further. Summary We have an exciting opportunity based in our US office working at the forefront of the gene editing (CRISPR knock-out, HDR, base editing) and gene modulation (CRISPRa, CRISPRi, RNAi) fields. As a Bioinformatics Scientist I, you will have the opportunity to apply your bioinformatics background, data analytical knowledge, and programming skills to make key contributions in support of Horizon’s gene perturbation and drug-target discovery screening platform. In addition, you will work with the bioinformatics team to assess, review, and develop new analytical and data science techniques to better identify and characterize genes of interest. Responsibilities • Work with senior bioinformatics scientists to develop, test, document, and support bioinformatics tools • Curate, analyze, and interpret complex data sets • Collaborate with scientists, product managers, and software engineers to understand and address the complex emerging needs of our scientists and customers • Build, curate, and query databases of gene editing/modulation and cell line engineering data • Prepare high quality client facing data packages and reports • Contribute to peer-reviewed manuscripts and deliver research presentations Requirements • MSc/PhD (or equivalent experience) in bioinformatics, computational biology, chemistry, physics, statistics, computer science, or a related field • Experience analyzing and interpreting complex data • A strong background in statistics and a keen interest in improving data analytical tools and methodologies • Experience programming in Python or R • Team player - enjoys collaborating with others to achieve shared goals and objectives Desirable Competencies & Requirements • Bioinformatics experience • Knowledge of version control (e.g. Git) • Fluent in Python and experience in other languages (e.g. R, Matlab) • Some familiarity with Bayesian statistics and machine learning techniques • Experience analyzing large and sparse data sets • Some experience handling or processing Next Generation Sequencing (NGS) data • Practical experience deploying and supporting pipelines/applications in an enterprise environment The salary range for this role is $89,000 - $100,000. This is the good faith range we believe is possible compensation for this role at the time of posting. We may ultimately pay more or less than the posted range and this range is only applicable for jobs to be performed in Colorado. This range may be modified in the future

We are seeking a talented and highly motivated Principal Bioinformatics Scientist to support development of Roche Diagnostics Molecular Assays that will impact patient care globally. This position requires a broad understanding of assay development on multiple technologies such as NGS, PCR, digital PCR, and microarray. The candidate will work closely with Bioinformatics, wet lab scientists and... external customers to develop and maintain internal algorithms and tools to support the Ariosa cell-free DNA System (AcfS) and development of PCR and NGS assays. Responsibilities: • Collaborate with Bioinformatics and wet lab scientists to envision, implement, and support tools for assays development • Lead scientific business analysis efforts to understand both internal & external customers needs • Provide hands-on troubleshooting to ensure data accessibility, quality, and integrity • Follow best practices for documentation and training of algorithms and tools • Present and communicate team activities/project results across multiple functions in the organization Required Skills & Experience: • Masters degree in Bioinformatics, Computational Biology, Statistics, Computer Science or a relevant subject area plus a minimum of 3+ years of proven experience • Strong statistics skills and proficient in using programming languages (R, Python) in a distributed Linux environment • Have good understanding of biology and IVD • Proven track record of supporting scientific informatics efforts. Ability to independently implement informatics solutions • Excellent written and verbal communication and scientific presentation skills • C++ or Java proficiency is a plus • Detail oriented and committed to delivering high quality clinical products Who we are At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, weve become one of the worlds leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity. Unless entitled to a reasonable accommodation under applicable law, employees are required to be fully vaccinated againstCOVID-19 in accordance with customer requirements, the companys health and safety obligations and/or applicable law or guidelines. Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individuals race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law. If you have a disability and need an accommodation in connection with the on-line application process, please email us atUS.Accommodation@roche.com. Job Level: Individual contributor

Invitae is dedicated to bringing comprehensive genetic information into mainstream medicine in order to improve healthcare for billions of people. The Clinical Informatics team is driven to make a difference for the patients we serve. We are leading the transformation of the genetics industry by making clinical-grade genetic information affordable and accessible to guide health decisions across... all stages of life. We are further building our team with junior members who will be working directly with production data on a daily basis. The team as a whole is responsible for the evaluation of the truth of clinically reportable variants and is often required to investigate unique genetic or genomic signals identified in production data. All of the team’s work directly impacts patient results, making problem-solving both motivating and rewarding. What You Will Do • Work collaboratively with other teams such as bioinformatics, clinical genetics, laboratory scientists, laboratory directors, and research scientists • Troubleshooting quality control anomalies generated by automated pipelines • Visualizing and assessing specific genetic variants and analyzing NGS data • Analyzing results from assays What You Will Bring • Bachelors degree in bioinformatics, or a related discipline and 2+ years related work experience or an advanced graduate degree in bioinformatics or related discipline or equivalent work experience • Experience with NGS data analysis in either academic or industry environment • Familiarity with common NGS alignment, variant calling, and visualization tools • Strong knowledge of genetics • Bonus: Familiarity and/or hands-on experience with NGS wet lab protocols, preferably in a production setting • Excellent written and verbal communication skills • Preferred: able to work on-site at San Francisco location, but open to remote candidates • Position requires availability either normal business hours M-F (with occasional weekend duties) or a shifted schedule of Su-Th or Tu-Sa. At Invitae, we value diversity and provide equal employment opportunities (EEO) to all employees and applicants without regard to race, color, religion, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of the San Francisco Fair Chance Ordinance

About AbbVie AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its... Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. The Genomics Research Center (GRC) is a center of excellence for genetics and genomics that supports both Discovery and Development. The GRC plays an integral role towards our goal of developing world class genetics and genomics research, focusing on finding the right targets and helping us better understand not only human disease biology but also the behavior of and response to our drugs in clinical trials. Within the GRC, the Department of Bioinformatics is responsible for data analysis and provides analytical insight for both internal and external data. This involves the identification and characterization of underlying genetic, epigenetic, or genomic factors that are associated with disease diagnosis, prognosis and response (efficacy and safety) to drug treatment, identification of new targets, and interpretation of the impact of genetic and genomic evidence from population-based studies. We have an exciting opportunity for a Senior Bioinformatics Scientist, based in North Chicago IL, Cambridge, MA or Remote. The candidate will work closely with computational biologists and research project teams in Immunology discovery to analyze genetics and multi-omics datasets to derive insights into immunological diseases, identify novel therapeutic targets and biomarkers specific to patient cohorts and Abbvie pipeline drugs. Key Responsibilities • Collaborate with research and bioinformatics scientists to conceive informatics analysis strategy leveraging advanced machine learning/AI algorithms to support discovery and pre-clinical studies. Specific applications can be but not limited to single cell sequencing data integration and analysis, digital pathology and molecular data integration, etc. • Draft specific project analysis plans and execute them per project analysis needs leveraging publicly available algorithms and libraries and internal computing infrastructure. • Collaborate with systems engineers from Abbvie AI team to build necessary computational infrastructure and pipelines. • Identify relevant internal and external immunological datasets and knowledge resources. Propose and execute computational research leveraging these integrated datasets. • Be abreast with most current machine learning/AI analysis methodology and algorithms and introduce them in-house when appropriate. • Communicate analytical results verbally and in writing for scientific and technical audiences and journal publications. Qualifications Position will be hired based on level of experience & education. • PhD in bioinformatics related quantitative sciences (such as computer science, applied mathematics, statistics, biomedical engineering) with biomedical data analysis experience. • 3+ years of project- based experience applying machine learning to knowledge graphs and other large- scale complex data is preferred. • Fluenct in Python or R with expertise in machine learning packages such as PyTorch, Tensorflow, and scikit-learn. • Ability to summarize analytical results, derive interpretation and recommend follow up actions to peer scientists. • Demonstrated ability to develop and execute custom computational and statistical analysis plans leveraging novel algorithms and relevant databases and statistical theory. • Prior working experience embedded within a biomedical research team. • Strong communication skills, innate scientific curiosity and collaborative team spirit. Preferred Qualifications • Working experience in biopharma industry. • Working experience with Spark/Hadoop. • Fluent with architecting cloud-based pipelines, including data modeling, indexing, and ETL (experience with Redshift/BigQuery, Apache Beam, Spark) • Experience in single cell data analysis (scRNAseq, CITE/REAP-seq, CyTOF) on immune datasets. • Genomics and genetic data analysis (populational or disease centric) experience. • Collaborative experience with system engineers. Significant Work Activities N/A Travel No Job Type Experienced Schedule Full-time Job Level Code IC Equal Employment Opportunity At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic

The CRoPS project aims to develop crop plants that sequester more carbon via extensive root systems containing recalcitrant carbon polymers to fight climate change. A major component of this research is to conduct genetic and genomic analysis for understanding traits relevant for this. Many of the genetic analysis depend on image acquisition and image processing.The Bioinformatics Analyst II will... work closely with other members of the CRoPS project and the Busch laboratory to advance image acquisition image processing, statistical genetics and genomics research projects. The analyst will contribute directly to research projects in the CRoPS project in the context of several computational analysis areas by implementing, optimizing and executing computational approaches for image segmentation and analysis, genome wide association mapping, genome sequence analysis, transcriptome analysis, and data visualization. Finally, the analyst will play part in administrating shared computer resources, such as compute and storage servers.ESSENTIAL FUNCTIONS Research Design and Presentation (5%) • Contribute and assist with project inception, experimental design, analysis and manuscript presentation • Assist with the preparation of data for, manuscripts, publications, grant applications, posters and other presentations • Present results verbally and with visual aids in one-on-one meetings, group meetings, or conferences • Maintain lab notebook, including experimental design, time, methods, materials and results Bioinformatics Analysis (85%) • Assist Institute researchers and contribute to scientific discovery by implementing, optimizing and executing computational approaches for image segmentation and analysis, genome wide association mapping, genome sequence analysis, transcriptome analysis, and data visualization • Work independently or with limited supervision on informatics research projects under direction from senior core staff or with research collaborators • Use published pipelines, scripts, and tools to prepare and process large datasets • Work in a high-performance computing environment • Keep informed of new developments and technical advances in the bioinformatics, image processing, visualization, genomics and biological fields related to current projects • Research, implement, and test, and present on new tools and pipelines for high throughput data analysis • Participate in the design and coding of analysis pipelines and cutting-edge bioinformatics analysis algorithms • Participate in the design, coding, and presentation of novel analysis tools for cutting edge bioinformatics analysis • Present advanced analysis results, tools, and pipelines at group meetings and contribute to publications in scientific journals ICG Bioinformatics Core Facility Maintenance and Management (10%) • Help maintain core scripts, software, website, tools, wiki, and pipelines • Help ensure that lab servers and hardware are operating properly and report all possible problems • Help users of lab software and servers to troubleshoot potential problems • Liaise with IT department and manufacturers with regard to hardware maintenance EXPERIENCE Required: • 4 years related experience or equivalent combination of education and experience. • A minimum of 1 year analysis experience with image analysis • Programming experience • Fluency in at least 2 common programming languages (Perl, Bash, Python, CIC++, Java, or R) • Experience in high performance computing • Good presentation and communication skills Preferred: • Experience with machine-learning algorithms and/or computational modeling • Experience with GPU computing • Experience with deep learning based image segmentation • Experience in statistics and machine • Experience in biology • Background in next-generation sequencing technologies and EDUCATIONRequired: • Bachelor’s degree in bioinformatics, computational biology, computer science, biological sciences, bioengineering, mathematics, statistics or related discipline or equivalent experience. Preferred: • MS or PhD degree in bioinformatics, computational biology, computer science, biological sciences, bioengineering, mathematics, statistics, or related discipline. SKILLS AND ABILITIES Required: • Proven organizational and time management skills to successfully set priorities, meet established deadlines and recognize new problems with constantly changing priorities and frequent interruptions • Strong communication skills (both verbal and written) needed to interact professionally and effectively in the work environment. Ability to read, comprehend, and discuss research materials. Proven ability to write, edit and proofread research results. Skill at explaining difficult concepts and training users and discuss • Ability to interact diplomatically and professionally with all levels of Institute staff and external contacts tools • Ability to identify, download, install, troubleshoot and assess new analysis tools • Experience analyzing images • Experience with Standard business office equipment and commonly used software and tools, such as Microsoft Office , electronic mail, and the internet Preferred: • Experience applying machine learning approaches for image processing, data integration and data mining • High proficiency in scientific programming languages (Perl, Python, C/C++, Java, R or Web applications) • Demonstrated knowledge and experience with MAC or Linux/UNIX operating systems • Experience in performing image analysis unsupervised and in recommending modifications to algorithms and workflows to meet the needs of research projects. Demonstrated ability to contribute to experimental design and assist with the analysis and interpretation of results • Theoretical and practical knowledge of biological sciences (particularly genetic and molecular biology). SPECIAL CONDITIONS OF EMPLOYMENT • Satisfactory completion of the lnstitute's background • Must be willing to sign confidentiality agreement • Must be willing to work in an animal-related research environment PHYSICAL REQUIREMENTS/MENTAL ACTIVITIES/ENVIRONMENTAL CONDITIONSThis position will be constantly adjusting focus, grasping, handling, hearing, keying, seeing, sitting, talking, touching/feeling, analyzing, calculating, communicating, reading, reasoning, writing and working inside

Job Desc Create tools, including developing, prototyping, and validating new features for genome analysis to enable better diagnostics andclinical management. Develop tools and algorithm for quality control, processing and analysis of whole genome sequence data, e.g., alignment, variant callers for types of variants Developing, prototyping, and validating new features for genome analysis Continuously scan the scientific literature to identify new approaches to genome analysis that can be implemented to improve our capabilities Qualification Ideally a master or PhD in a strongly quantitative discipline such as (e.g. data science, computer science, or maths) with experience as data scientist working on bioinformatics, or equivalent experience, in one of the following: genetics/genomic with a strong computational component, statistical genetics, genetic epidemiology, bioinformatics with the focus on human genomics. Experience with NGS data analysis from sequencing QC to annotation... and variant calling. Able to write in R, Python and Perl Statistical background in multivariate analysis is a plus

Requirements: • Bachelor or Master of Science in Biotechnology, Biochemistry or in science-related fields • 2 years of relevant experience, generally as a bioinformatician and hands-on analyzing microarray genotype data • Have qualified knowledge in the field of molecular biology, human genomics and data population • Proficiency with R and Phyton are plus points • Excellent interpersonal, oral, and written communication skills • Ability to work independently as well as in teams • Strong background in bioinformatics and/or computational biology Key Responsibilities for the Data Scientist (Bioinformatics) include: • Perform quality analysis of human based on genotyping data • Conduct research and applied statistical genetics analyses • Present statistical data for sample characteristics and genotyping results, report and visualization to R&D Team and stake holder • Assist in development of analysis pipelines and internal database and findings • Collaborate with geneticists and... technology team in the development of genomics application • Contribute to establish protocols and scientific publications

Job Desc: • Create tools, including developing, prototyping, and validating new features for genome analysis to enable better diagnostics andclinical management. • Develop tools and algorithm for quality control, processing and analysis of whole genome sequence data, e.g., alignment, variant callers for types of variants • Developing, prototyping, and validating new features for genome analysis • Continuously scan the scientific literature to identify new approaches to genome analysis that can be implemented to improve our capabilities Qualification: • Ideally a master or PhD in a strongly quantitative discipline such as (e.g. data science, computer science, or maths) with experience as data scientist working on bioinformatics, or equivalent experience, in one of the following: genetics/genomic with a strong computational component, statistical genetics, genetic epidemiology, bioinformatics with the focus on human genomics. • Experience with NGS data analysis from sequencing QC to... annotation and variant calling. • Able to write in R, Python and Perl • Statistical background in multivariate analysis is a plus

Position Overview: We are hiring a bioinformatics specialist interested in developing a clinical decision support for implementation of genetics in clinical settings. The person will be responsible of building analytical pipelines forpatients’ genomic, demographic, and individual data, as well as working with our senior software engineer tointegrate our knowledge base with existing EHR systems. The ideal candidate has experience in buildingclinical annotation and analysis pipelines related to patients’ genomics, demographics, and individual data. Key responsibilities • Develop, maintain, and improve qPCR-based and recommendation-based bioinformatics pipelines; • Curate real-world evidence using programming languages; • Document bioinformatics pipelines according to ISO standards; • Develop and support novel bioinformatics solutions for external collaboration projects; • Implement new methods in genetic data analysis and product development • Ensure relevance and accuracy of... our clinical decision support Experience required • Experience in working with qPCR data • Firm understanding of human genetics and association studies • Knowledge of genomic data exploration/analysis/visualization with R/Python and Bash. • Analytical pipeline development and optimization • Familiar with commonly used development tools, such as MySQL, AWS EC2, and lambda • Good documentation and organizational skills • Ability to work with collaborators on existing research projects. • Independent, with a positive attitude and a good team player. Minimum education qualification • Bachelor or Master’s or PhD in Computational Biology, Bioinformatics, or a related field. Technical Skills (preferred) • MySQL • AWS • EHR systems (any) About Nalagenetics Nalagenetics is a venture backed Singaporean company aiming to increase efficacy of prescription and reduce adverse drug reactions using genetic testing and information management systems. We develop core capabilities in three areas: affordable genetic testing, clinical decision support (CDS), and web/app for post- prescription follow up. Since April 2016, we have deployed 1,000 of our leprosy test in Papua to prevent Dapsone Hypersensitivity Syndrome (DHS) in leprosy patients. We were incubated at Harvard’s Venture Incubation Program and Harvard Business School’s Rock Accelerator and Summer Fellowship, and accepted in Techstars NY. Nalagenetics is mission-driven: two of our co-founders have seen first-hand adverse reaction through close family members- that experience taught us advanced innovations are in pharma and biotech would not mean much without knowing how to best apply it to our population. https://www.nalagenetics.com/#/blog-detail/career-opportunity-bioinformatician-qpcr-and-annotation-directions