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More Bioinformatics Jobs

Advisor - Off-Target Computational Biology

Cambridge, MA

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and... volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. At the Lilly Innovation Center in Cambridge, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our team in Cambridge shares a real passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts’ exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world. Off-Target Computational Biologist Advisor At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Eli Lilly and Company is seeking a Computational Off Target Advisor to join our team in Cambridge, MA. Come join the rapidly expanding Gene Editing team at Eli Lilly! We are responsible for inventing, characterizing, and advancing novel genome editing reagents for a myriad of clinical applications. Our team works cross-functionally within our organization across multiple disease areas and platforms. Our goal is to deliver on the promise of gene editing to patients around the world. Job Responsibilities • Build a pipeline to identify and quantify levels of off-target editing from different nuclease modalities • Assist the lab team in creating robust off-target pipelines from concept through analysis • Hire and manage a team to deliver on timelines as the programs and team expands • Work with data scientists to distill complex information to a cross-functional audience Job Requirements • PhD with 0-2+ years of experience, or BS/MS with 5+ years of experience. Additional Skills/Preferences: • Mastery of NGS data handling, from processing raw reads through to running or building pipelines for analysis • Some experience working with off-target data, including datasets from GUIDE-Seq, SITE-Seq, etc Additional Information: • This role may require up to 10-15% travel for conferences or training and may include the opportunity to mentor and train two junior scientists. • The position is located at 215 First St, Cambridge, MA 02142. Full time (40 hours/week). Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response. Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups. #WeAreLilly

Senior/Principal Scientist, Bioinformatics

Waltham, MA

Senior/Principal Scientist, Bioinformatics Skyhawk is looking for a talented and inspired Senior/Principal Bioinformatics Scientist to join our Bioinformatics team. In this role you will report directly to the Director of Bioinformatics and be responsible for advancing RNA-targeting drug discovery with computational tools. The primary responsibilities of the role include developing algorithms... software packages, and analysis pipelines for various omics data. Applicants should be self-starters and excited about the opportunity to operate in a multi-faceted bioinformatics function within a growing, fast-paced company. Role and Responsibilities (include, but are not limited to): • Independently develop algorithms, software packages, analysis pipelines, and notebooks to process, analyze, visualize, and interpret proprietary and public omics data. • Analyze and integrate RNA-seq, Amplicon-seq, Nanopore, eCLIP, proteomics, and other data to characterize the selectivity and mechanism of action for novel RNA-targeting small molecules. • Design and implement novel analytic methods and metadata management tools for interrogating high-throughput screening NGS data to identify novel chemical matters for new RNA targets. • Provide computational support at various stages of preclinical drug discovery. • Interact with counterparts from discovery biology, chemistry, high-throughput screening, data management, and IT to account for their insights and needs. • Manage project timelines with internal personnel and external vendors. Education/Skills/Experience Requirements: • Ph.D. in Bioinformatics, Computational Biology, Computer Science, or a related field. 3-5+ year post-graduate experience is preferred. Title commensurate with experience. • Strong programming skills with Python, R, Perl, Bash and expertise in statistical analysis. Familiar with Git version control, HPC and AWS cloud computation, Nextflow, data science and visualization packages (e.g. pandas, NumPy, scikit-learn, ggplot2, Plotly). • Proficient with differential splicing, differential gene expression, pathway enrichment analyses, and transcriptome assembly with RNA-seq data. • Track record of software packages, analysis pipelines, and publications in computational RNA biology. Deep and broad knowledge of alternative splicing regulation in diseases. • Experience of mining multi-omics data from thousands of samples with machine learning techniques, such as clustering and classification, is a plus. • Excellent written and verbal communication skills and organizational and documentation skills. • Ability to manage multiple projects simultaneously and manage priorities/timelines flexibly

Scientist/Senior Scientist, Bioinformatics

Somerville, MA

Bioinformatics Scientist / Senior Scientist Harbinger Health, a Flagship-founded company, is pioneering early cancer detection. Harbinger aims to detect cancer, at the earliest stages, to save lives. Our platform leverages proprietary biological insights and artificial intelligence to enable high-resolution, molecular views on cancer from blood. We are a highly dynamic, entrepreneurial, and... innovation-driven organization seeking collaborative, passionate, and dedicated people to join our team. Flagship Pioneering conceives, creates, resources, and develops first-in-category bioplatform companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in more than $200 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 42 transformative companies, including Axcella Health (Nasdaq: AXLA), Codiak BioSciences (Nasdaq: CDAK) Denali Therapeutics (Nasdaq: DNLI), Evelo Biosciences (Nasdaq: EVLO), Foghorn Therapeutics (Nasdaq: FHTX), Indigo Ag, Kaleido Biosciences (Nasdaq: KLDO), Moderna (Nasdaq: MRNA), Omega Therapeutics (Nasdaq: OMGA), Rubius Therapeutics (Nasdaq: RUBY), Sana Biotechnology (Nasdaq: SANA), Seres Therapeutics (Nasdaq: MCRB), and Sigilon Therapeutics (Nasdaq: SGTX). Position Summary Harbinger Health is seeking an innovative and highly motivated Scientist/Senior Scientist in the bioinformatics department. The candidate will be responsible for R&D of bioinformatics algorithms and drawing insights from explorations of the genomics data. The successful candidate should have significant experience in data science in genomics, demonstrated via first author publications and conference presentations. Also demonstrating ability to write high quality code is needed, as the algorithms will transition from R&D into production pipeline in a regulated environment. Additionally, the candidate will need to demonstrate strong communication skills, especially with teams who closely collaborate with bioinformatics. Key Responsibilities: • Develop and perform bioinformatics analyses of NGS data, with emphasis on bisulfite sequencing • Analyze internal and external data sets to address biological questions critical to Harbinger’s core mission. • Apply rigorous statistical methods for extracting and summarizing biological insight that live in high dimensionality space • Work closely with other computational and experimental scientists to design experiments • Effectively communicate findings to stakeholders Required Skills: • Ph.D. in bioinformatics, computational biology, biostatistics, or a related quantitative field; or M.S. with relevant work experience • 3+ years experience in analysis of complex biological datasets, demonstrable via publications, presentations, and/or patents • Strong scientific programming experience in Python (preferred) or R or Matlab, demonstrated via github or publications • Experienced and proficient with experimental design, data processing, statistical analysis, and bioinformatics analysis/reporting of next-generation sequencing (DNA, bisulfite, RNAseq, single-cell NGS, and/or exome sequencing) and microarray platforms. • Comfortable in working with a Linux environment, using high performance computing in a cloud • Motivated and team oriented, with track record to thrive in a fast-paced and multi-tasking environment. • Strong communication and presentation skills. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto

Director, Bioinformatics Core

Boston, MA

When you join the growing BILH team, you're not just taking a job, you’re making a difference in people’s lives. Job Type... Regular Scheduled Hours: 40 Work Shift: Day (United States of America) About us: The BIDMC Bioinformatics Core (BBC) is part of the Precision RNA Medicine Core at Beth Israel Lahey Health. The BBC will be tightly integrated with the ‘Omics cores at BIDMC. It is the center for bioinformatics research expertise at BIDMC. We work directly with biomedical scientists across our Network and the Harvard community to implement best practice for analysis, interpretation, visualization, and dissemination of scientific discoveries using high dimensional data. The BBC team focuses on teamwork and we provide a supportive learning environment. About you: You understand the growing need for data driven research. You have a solid track record in bioinformatics service provision, excellence in communication skills and written and verbal reporting. A thorough knowledge of current and upcoming developments in analysis of high dimensional data, genomics and the current developments in bioinformatics are essential. Management skills should be evident, with a particular focus upon project management, the ability to define specific project requirements and to execute upon specifications. Evidence of having managed developers is of value. Publications should reflect a collaborative approach – with diversity of subjects being of interest. You should be able to articulate the vision of the program, and must be able to work independently. You are not shy of taking on core projects where you provide direct consulting, or work with teams to provide consulting to biomedical researchers. Your background is in biomedical/quantitative science with evidence of strong interest in working with researchers in diverse areas of biomedical research. You thrive on scientific challenges, enjoy collaborating with an interdisciplinary team and excel at communicating and coordinating between computational and wet-lab scientists. Learning and applying new methods is natural for you, and you are motivated to continuously expand your skills. You have superb data and project management skills. Working on different projects and deadlines, frequently in collaboration with other Cores and research groups, does not intimidate you. Job Description: Job Summary: The Bioinformatics Core Director will have strategic and tactical responsibility for the operations of the core, consultation, recruiting, overseeing core support staff and provision of leadership in developing core resources and providing research support and training for research faculty and staff at BIDMC. The Core Director will lead a team that develops and applies bioinformatics workflows for standard and custom data analysis across a broad range of technologies, such as single nuclei sequencing, spatial transcriptomics, genome variant analyses, transcriptomics or epigenomics. The Core Director is expected to create deliverables that could serve as standards for quality and innovation in broader communities, building informatics tools for data management, omics and imaging analyses within the reality of clinical data integration. The team will support researchers across the research community with their data management, quality control, analysis of data and presentation of results and will also be expected to coordinate selected research or support projects and act as an independent point of contact for researchers. Essential Responsibilities: 1. Determine BIDMC needs and work with core Scientific Directors in setting strategic, scientific and operational priorities. 2. Provide best practice bioinformatics services to investigators across campus, including pre-experiment/grant consulting, application and training on the use of bioinformatics core software tools, and integration of user-generated and large-scale public data sets. 3.Develop staffing plans and oversee recruitment; oversee developers as necessary, provide management of database design, interface design and information processing. 4. Co-ordinate a monthly seminar series, special trainings and mini-courses and organize user groups for bioinformatics related activities. 5. Develop and promote the funding model for expansion and sustainability of the core, including investments from organizational units around the community, charge-back models and collaborative grant applications to ensure long term sustainability. 6. Lead and collaborate on grant applications related to bioinformatics core projects. 7. Enable implementation of scalable workflows to disseminate analytical advances to the research community. 8. Engage with the community to both embrace and develop best practice. 9. Participate in leading national and international efforts aimed at establishing best practices and standards for omics basic science and potentially integration with clinical data representation and analysis. 10. Has full responsibility for planning, monitoring and managing department budget. Required Qualifications: Master's degree required; Doctoral degree preferred. 5-8 years related work experience required and 5-8 years supervisory/management experience required Demonstrated excellence in analytical, writing, and communication skills; A commitment to providing bioinformatics support for a broad range of scientific projects; Experience in developing and managing projects and people. Extensive knowledge of public domain bioinformatics data sources, public sequence databases, genomics tools, single cell analyses, and gene expression analysis. Evidence of software development experience and proficiency in scripting; Experience with SQL or other relational database systems, Unix and mixed operating systems environments, high-dimensional data management and analysis; Proficient in R and Bioconductor. Advanced skills with Microsoft applications which may include Outlook, Word, Excel, PowerPoint or Access and other web-based applications. May produce complex documents, perform analysis and maintain databases. Competencies: Decision Making: Ability to make decisions that are guided by general instructions and practices requiring some interpretation. May make recommendations for solving problems of moderate complexity and importance. Problem Solving: Ability to address problems that are varied, requiring analysis or interpretation of the situation using direct observation, knowledge and skills based on general precedents. Independence of Action: Ability to set goals and determines how to accomplish defined results with some guidelines. Manager/Director provides broad guidance and overall direction. Written Communications: Ability to communicate complex information in English effectively in writing to all levels of staff, management and external customers across functional areas. Oral Communications: Ability to verbally communicate complex concepts in English and address sensitive situations, resolve conflicts, negotiate, motivate and persuade others. Knowledge: Ability to demonstrate in-depth knowledge of concepts, practices and policies with the ability to use them in complex varied situations. Team Work: Ability to lead and direct multiple collaborative teams for large projects or groups both internal and external to the Medical Center and across functional areas. Results have significant implications for the management and operations of the organization. Customer Service: Ability to lead operational initiatives to meet or exceed customer service standards and expectations in assigned unit(s) and/or across multiple areas in a timely and respectful manner. Physical Nature of the Job: Sedentary work: Exerting up to 10 pounds of force occasionally in carrying, lifting, pushing, pulling objects. Sitting most of the time, with walking and standing required only occasionally FLSA Status: Exempt As a health care organization, we have a responsibility to do everything in our power to care for and protect our patients, our colleagues and our communities. Beth Israel Lahey Health requires that all staff be vaccinated against influenza (flu) and COVID-19 as a condition of employment. Learn more about this requirement. More than 35,000 people working together. Nurses, doctors, technicians, therapists, researchers, teachers and more, making a difference in patients' lives. Your skill and compassion can make us even stronger. Equal Opportunity Employer/Veterans/Disabled

Sr. Bioinformatics Scientist


Salary: Sr. Bioinformatics Scientist... About Catalytic Data Science (CDS): REMOTE OPPORTUNITY Catalytic Data Science is a groundbreaking cloud R&D platform designed to integrate the volumes of scientific resources, data, and analytic tools while providing the ability to network with colleagues in one secure and scalable environment. By enabling R&D teams to work more collaboratively and improving productivity company-wide, the Catalytic platform helps teams achieve key R&D milestones faster and with greater accuracy. Our customers are passionate about making the world a better place, and we are inspired by the opportunity to help them. Who You Are: A self-motivated bioinformatician with experience in next-generation sequencing, systems biology, and/or multi-omics. You are eager to help build a digital workspace with a direct impact on human health, pharmaceutical research, and Life Sciences companies. The successful candidate will play an important role in building up data analysis capabilities, ranging from biomarker discovery to visualization and interpretation of results. You will join exceptional software developers, engineers, and scientists in a fast-paced, open, innovative, and fun environment. He/She will report to the Chief Science Officer but will work closely with other company leaders to ensure company success. Responsibilities: • Compare and implement state of the art methods in NGS (e.g., WGS, WES, WTS, etc.) pipelines; • Develop algorithms with technology development teams to transform cutting-edge science into novel software applications; • Analyze sequencing data and work with our scientists to answer specific biological questions; • Provide technical guidance and customer support in the design and analysis of experiments in R • Prepare technical reports, presentations, and manuscripts detailing key methodologies and results; • Troubleshoot and maintain bioinformatics pipelines. Qualifications • D. degree with 2+ years (or MS degree with 5+ years) of working experience in the industry in the field of systems biology, bioinformatics, computational biology, or equivalent; • Solid computational skills and a deep understanding of NGS data and its analysis; • Familiarity with git version-control workflows; • Extensive experience in NGS, systems biology and analysis of large-scale ‘OMICS datasets; • Proficient in either R or Python; • Prior experience working on a scalable, high-volume, web-based application; • Familiarity with Atlassian JIRA; • Experience with Docker containers and immutable infrastructures; • Experience working in a cloud-based environment (preferably AWS); • Excellent personal and communication skills, including solid presentation and writing skills; • Must be self-motivated, a quick learner, dedicated to achieving excellence, and love to take on new challenges. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification document form upon hire

Bioinformatics Engineer (Capsid Discovery)

Cambridge, MA

About Voyager Voyager Therapeutics (Nasdaq: VYGR) is a biotechnology company dedicated to breaking through barriers in gene therapy and neurology. The potential of both disciplines has been constrained by delivery challenges; Voyager is leveraging innovative expertise in capsid discovery and deep neuropharmacology capabilities to address these constraints. Voyager’s TRACER AAV capsid discovery... platform has generated novel capsids with high target delivery and blood-brain barrier penetration at low doses, potentially addressing the narrow therapeutic window associated with conventional gene therapy delivery vectors. This platform is fueling alliances with Pfizer Inc., Novartis and Neurocrine Biosciences as well as multiple programs in Voyager’s own pipeline. Voyager’s pipeline includes preclinical programs in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis (ALS), each with validated targets and biomarkers to enable a path to rapid potential proof-of-biology. For more information, visit Job Summary Voyager Therapeutics is seeking an innovative, collaborative, and enthusiastic bioinformatician to work on a variety of high-dimensional bioinformatics projects centered on target identification, drug discovery and translational research. Play a key role in integrating and analyzing internal and external datasets from high throughput assays such as NGS, scRNA Seq, etc. They will focus on the implementation and maintenance of effective pipelines to process, manage and analyze data from genomic platforms. A critical component of the job will be the close collaboration with research scientists and other computational scientists on the application of research methods as well as the management, visualization, and presentation of data to help guide a multi-disciplinary internal discovery teams. Key Responsibilities • Work with Computational Biology team to develop and apply custom bioinformatics algorithms and software to solve complicated computational challenges. • Apply, maintain, and improve robust analytic pipelines to process, organize and integrate large scale internal/external genomic data sets. • Work with external partners to support research as needed. • Design and implement accompanying tools for data visualization and presentation. • Provide customized ad-hoc analysis support to Lab Scientists, including the identification/application of commercial/published tools to support research goals. • Organize, interpret and present data for peer-review Qualifications • MS/BS in Computational Biology, Bioinformatics, Statistics, Computer Science with 0-2 yrs. of experience in industry and/or academic research; knowledge of scientific principles and concepts. Prior work in oncology/immunology a plus. • Technically proficient in statistical analysis (e.g., Python and R) and engineering for data science (e.g., version control, containerization, and workflow languages like Nextflow) • Experience with NGS data and NGS analysis pipeline setup and execution • Experience applying new tools for the integrative analysis and visualization of multi-dimensional datasets • Track record of building, tuning and operationalizing machine learning models • Experience sharing data solutions using web apps such as Streamlit and R-Shiny to a wider audience • Excellent verbal, written, analytical, and presentation skills; communicate a clear vision down, up, and across

Sr./Principal Scientist, Bioinformatics

Boston, MA

Frontier Medicines is seeking a highly motivated and experienced Senior/Principal Scientist in Bioinformatics or Computational Biology to join an emerging Bioinformatics group embedded in our growing Data Sciences team. The ideal candidate has proven experience in the analysis of high-dimensional omics data derived from multiple platforms (such as RNA-seq, Chip-seq, WES/WGS, MS-based proteomics... metabolomics, RPPA, etc.) The successful candidate will lead the conceptualization and implementation of analytical strategies and in developing and implementing novel algorithms to further advance our innovative proteome-wide profiling pipeline. This role requires creativity and ingenuity in developing analysis methods, including machine learning/AI type algorithms on our proprietary data to generate actionable insights. Given that our platform is unique and novel, the candidate should also cherish working in uncharted territory and be curious to find solutions where no template exists. This is an exciting opportunity in our Boston site to help making a difference for patients suffering from debilitating diseases. You will be working as part of a highly collaborative and energetic team in a startup environment with short communication lines across functions and departments. What are we looking for? • PhD in Bioinformatics, Computational Biology, Computer Science, or a related field. • 5+ years of post-graduate experience in bioinformatics and computational biology. • In-depth knowledge and hands-on experience in analyzing various high-throughput biological data, such as RNA-seq, WES, WGS, Chip-seq. Experience with analyzing patient level data is a plus. • Demonstrated ability to design and implement bioinformatics pipelines, algorithms, and software tools to solve complex biological problems. • Proficiency in programming languages commonly used in bioinformatics, such as R and Python, as well as experience with statistical analysis packages, such as Bioconductor, SciPy. • Experience working with databases and query languages (RMDB Oracle, MySQL, MongoDB, Document DB). • Comfortable with common software development practices such as version control (Git), containerization, unit testing, and cloud computing environments. AWS experience is a plus. • The successful candidate will not only closely interact with fellow data scientists but also be an integral part of multidisciplinary drug discovery teams with the goal to innovate our chemoproteomic experiments and analysis workflows and further advance our proprietary platform in the quest to discover novel and life changing medicines. • Familiarity with standard bioinformatics tools and databases (e.g., UniProt, Ensembl, GSEA, DepMap, cBioPortal, etc.). • Proficiency in applied statistics (e.g., parametric and non-parametric tests, ANOVA, linear models) and basic data science methods (e.g., anomaly detection, dimensionality reduction) are required. • Expertise in machine learning, data mining, and other advanced computational techniques for large-scale data analysis. • Experience in advanced analytics and data science methods (e.g. random forest, neural networks and deep learning, Bayesian classification) is a plus. • Legally authorized to work in the US. How will you grow with us? • The successful candidate will not only closely interact with fellow data scientists but also be an integral part of multidisciplinary drug discovery teams with the goal to innovate our chemoproteomic experiments and analysis workflows and further advance our proprietary platform in the quest to discover novel and life changing medicines. • Health Care Plan (Medical, Dental & Vision) • Retirement Plan (401k, IRA) • Life Insurance (Basic, Voluntary & AD&D) • Paid Time Off (Vacation, Sick & Public Holidays) • Family Leave (Maternity, Paternity) • Short Term & Long Term Disability • Training & Development • Free Food & Snacks • Wellness Resources • Stock Option Plan At Frontier we strive to build a diverse and equitable workplace. The salary range for this role is $135,000 - $203,000. Compensation for the role will depend on a number of factors, including candidates' qualifications, skills, competencies and experience. Frontier offers a competitive total rewards package which includes healthcare coverage, 401k and a broad range of other benefits. This compensation and benefits information is based on Frontier’s knowledge as of the date of publication, and may be modified in the future

Scientist, Bioinformatics

Cambridge, MA

The Role Moderna is seeking an exceptionally talented and highly motivated bioinformatics scientist with RNA biology background to work as part of a highly collaborative, multi-disciplinary, and fast-paced team. The successful candidate will develop novel algorithms and leverage all available bioinformatics and analytics tools to support R&D projects and RNA therapeutic programs... The successful candidate must have a very strong foundation in algorithm development (as documented by publications in peer-reviewed journals) and experience in applying machine learning and deep learning models in the field of RNA therapeutics. This position has significant visibility and potential for growth in a dynamic organization. Here’s What You’ll Do • Develop and apply novel combinatorial optimization algorithms to solve the needs and challenges specific to developing mRNA medicines • Work with RNA biologists, the high throughput screening team, and the NGS team to acquire appropriate datasets to train, build, refine machine learning models • Utilize deep understanding of scientific literature and concepts to drive innovation for mRNA design • Contribute to scientific and strategy discussions to advance and enhance the Moderna mRNA Platform • Maintain accountability for project success and result delivery • Communicate research findings to both technical and non-technical collaborators internally and externally Here’s What You’ll Need (Minimum Qualifications) • Ph.D. in Computer Science, Bioinformatics, Computational Biology, Statistics, Physics, or related field with post-doctoral training • Minimum 1 year biology experience in academic or industry required • Algorithm development experience required • Experience applying machine learning and deep learning models required Here’s What You’ll Bring to the Table (Preferred Qualifications) • Experience with applications in RNA biology • Familiar with RNA secondary structure prediction tools and principles • Experience analyzing NGS data from chemical probing experiments, e.g. SHAPE • Experience with programming or scripting language (multiple preferred), e.g. Python, R • High performance computing in a distributed/cloud environment, e.g. AWS • Software development best practices, including agile, version control, unit and integration testing, documentation, and deployment • Ability to manage multiple concurrent, fast-paced projects and to work with collaborators from both wet lab and dry lab • An established record of innovative research achievements in machine learning/bioinformatics reported in top-tier journals and patent applications • Excellent written and oral communication skills • Positive team building and teamwork skills: innate ability to influence, lead and inspire people, within function and beyond functional/company boundaries Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including: • Highly competitive and inclusive medical, dental and vision coverage options • Flexible Spending Accounts for medical expenses and dependent care expenses • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities • Family care benefits, including subsidized back-up care options and on-demand tutoring • Free premium access to fitness, nutrition, and mindfulness classes • Exclusive preferred pricing on Peloton fitness equipment • Adoption and family-planning benefits • Dedicated care coordination support for our LGBTQ+ community • Generous paid time off, including: • Vacation, sick time and holidays • Volunteer time to participate within your community • Discretionary year-end shutdown • Paid sabbatical after 5 years; every 3 years thereafter • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents • 401k match and Financial Planning tools • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options • Complimentary concierge service including home services research, travel booking, and entertainment requests • Free parking or subsidized commuter passes • Location-specific perks and extras! About Moderna Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world. By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit to learn more about our current opportunities. Moderna is a smoke-free, alcohol-free and drug-free work environment. Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply! Moderna is proud to be an equal opportunity workplace and is an affirmative action employer. Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements. Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best. Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at (EEO/AAP Employer)


Boston, MA

Bioinformatics and Molecular Data team is a growing group at the Informatics and Analytics Department (I&A) of Dana-Farber Cancer Institute (DFCI). The team addresses unmet needs for bioinformatics, data management, data mining and analysis across research, clinical, and operational units. It accelerates use of bioinformatics and data science methods, data, and tools within DFCI, bridging the gap... between research and clinical practice and helping design and implement operational solutions. The group encompasses expertise in bioinformatics, data science, machine learning, and software engineering. It works with some of the most prominent research and clinical DFCI programs, from basic research to translational research, to clinical diagnostics and operations. We look for an intelligent, hard-working, and dynamic individual to fill the role of Bioinformatics Scientist in the team. The successful candidate will support key initiatives relying on genomic data, have the ability to lead projects and potentially, in the future, may lead other people within the team. Specifically the role will work on an exciting new initiative to develop a cloud-based bioinformatics analysis platform. The platform will enable DFCI researchers to easily manage and analyze their genomic and biomedical data in the cloud environment, build and run analysis workflows and visualize the results. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The successful candidate will have proven experience in managing and independently executing complex bioinformatics tasks in the frame of Bioinformatics Workbench project. The role’s responsibilities will include: • Owning and leading various projects, serving as a subject matter expert. • Developing and implementing bioinformatics tools and pipelines in cloud environment. • Collaborating with DFCI software engineering and data science teams as well as interacting with external cloud and other technology vendors. • Meeting, consulting, and providing computational and informatics support to various DFCI scientists and independent faculty members in designing and executing key biomedical projects. • Collecting, analyzing, interpreting, and integrating complex biomedical data. • Delivering results for projects and generating relevant reports. • Working as a part of the broader team to identify and implement longer-term solutions that will improve quality, speed and efficacy of our current projects and programs through evaluating and benchmarking new software tools and pipeline development. • Contributing expertise to DFCI software code base and communities of practice. Minimum Education: Bachelor’s degree required in a STEM field. Master’s degree or PhD strongly preferred in bioinformatics, medical informatics, computational biology, statistics, computer science/engineering, or a related quantitative field. Minimum Education: 3 Years of experience required; Master’s degree with 1 year experience required; PhD with 0 years. • Deep bioinformatics skills at the interface between bioinformatics programming and understanding of biological and clinical problems. • Experience in analysis of the next generation sequencing data, e.g. WXS/WGS, RNA-Seq, etc; experience in single-cell and/or ctDNA data analysis is a plus. • Working knowledge of IA and machine learning approaches used in bioinformatics research • Experience in one or more areas of cancer research, including solid tumors, hematologic malignancies, patient-derived cancer models, biomarker discovery, etc. is a major plus. • Excellent communication and effective problem-solving skills, track record in serving a variety of diverse customers and projects. • Proven ability to work independently, prioritize, and manage people if needed, within an environment with evolving priorities. At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. EEOC Poster

Bioinformatician - Open Rank

Worcester, MA

Overview POSITION SUMMARY... Under the direction of a member of the faculty, the Bioinformatician is responsible for the design, development, evaluation and iterative modification of a technical infrastructure to expedite the quantitative evaluation of data resulting from studies that are laboratory based. The position will entail the establishment and maintenance of applicable in-house bioinformatics resources and interaction with individual lab members on customized research projects, as well independent projects that are the solely computational. This is an open-rank posting (there are 4 levels of Bioinformatician) - candidates will be hired into the level commensurate with their experience. Responsibilities ESSENTIAL FUNCTIONS: Bioinformatician I: • Establish general bioinformatics resources for day-to-day use by members of the laboratory • In collaboration with a faculty member, generate customized programming solutions to improve user interaction with available bioinformatics resources • Assist in the implementation of programs for microarray analysis, high-throughput sequencing data analysis, cis regulatory motif identification, and multi-genome protein motif searches • Local establishment and customization of model organism genomic databases and tools for batch sequence analysis utilizing these resources • Interpret and present study results in support of laboratory members • Provide tabular and written summaries of approaches and analyses in a form suitable for inclusion in manuscripts or grant applications, as well as media for presentation at scientific meetings • Develop and implement custom bioinformatics programming solutions in collaboration with lab as necessary • Coordinate and collaborate with other research computing expertise at the Medical School as necessary • Participate in conference calls and data management meetings as needed • Perform other duties as required. Bioinformatician II: Duties noted above plus: • Implement and adapt programs for microarray analysis, high-throughput sequencing data analysis, cis regulatory motif identification, and multi-genome protein motif searches. • Independently develop, implement and maintain custom designed computational solutions relevant for ongoing lab-based projects. • Independently develop, implement and maintain computational methods for meta-analysis of data generated in the lab as well as publicly available data. • Independently execute a scientific computational project (e.g. a project that can result in a first author publication) Bioinformatician III: Duties noted above plus: • Design and implement reusable bioinformatics analysis pipelines for processing next-generation sequencing, microarray, genomics, proteomics and chemogenomics data. • Integrate computational methods/pipelines with high performance computing clusters. • Collaborate closely with PIs and their lab members on research projects including defining the scope of the collaboration, researching on the scientific topics, and implementing the appropriate bioinformatics solutions that meet timelines. • Participate in the oral presentation of all project findings and abstracts including participation in periodic project status meetings and presentation of final project deliverables. • Develop rapid prototypes and custom scripts for one-off type of analysis requests. • Develop novel algorithms and integrated data visualization applications when existing software packages are not available or adequate. • Properly document the procedures used in computational analysis and provide summary report of results suitable for inclusion in manuscript and grant applications. • Local establishment and customization of genomic, proteomics databases and provide batch analysis utilities that make use of these resources. • Develop custom databases and web portals for managing raw and processed experimental data. • Provide bioinformatics training and workshops for analysis pipelines and in-house developed software applications. • Coordinate and collaborate with other bioinformaticians, biostatisticians, information technology professionals, and interdepartmental project teams. Sr Bioinformatician: Duties noted above plus: • Lead the design and implementation of reusable bioinformatics analysis pipelines for processing next-generation sequencing, microarray, genomics, proteomics and chemogenomics data. Ensure pipelines meet end-user needs and project timelines • Independently initiate and manage research collaborations. Work closely with PIs and their lab members on research projects including defining the scope of the collaboration, researching on the scientific topics, and implementing the appropriate bioinformatics solutions • Closely follow the latest development in high-through technologies, pioneer in bioinformatics analysis on novel datasets and facilitate sharing of knowledge and best practices • Independently develop novel algorithms and bioinformatics applications when existing software packages are not available or adequate • Prepare scientific manuscripts and abstracts including primary authorship of bioinformatics research papers • Organize bioinformatics training and workshops for analysis pipelines and in-house developed software applications • Liaison with Information System department to ensure high performance computing needs for research are properly addressed • Mentor rotation and summer internship students and junior members in the group Qualifications REQUIRED QUALIFICATIONS: Bioinformatician I: • BS in computer science or a related discipline • 0-1 year of related experience • Strong background in statistical methodology, software languages and computer systems (Perl, C++, R, MySQL, etc.) • Experience in writing basic search algorithms and the ability to generate new algorithms and programs for custom data manipulation and analysis • Excellent communication skills, both oral and written, and interpersonal skills necessary to interact with a wide range of individuals Bioinformatician II: • Requirements noted for Bioinformatician I plus: • 1-3 years of related experience • Co-authorships on peer-reviewed publications are strongly suggested but not required Bioinformatician III: • Requirements noted for Bioinformatician I plus: • Master's degree in Computer Science, a related computational discipline, or equivalent experience • 1-3 years of bioinformatics-related research experience • Proven research record such as co-authorship on peer-reviewed publications required • Strong background in programming. Fluent in one programming language (Java or C/C++) and one scripting language (shell, Perl or Python) • Knowledge in biostatistics packages (R or Matlab) and SQL queries are strongly suggested • Strong communication skills, both the oral and written necessary to interact with a wide range of individuals Sr Bioinformatician: • Requirements noted for Bioinformatician I plus: • Master's degree in Bioinformatics, Computer Science, or related computational discipline • 3-5 years bioinformatics-related research experience • Knowledge in biostatistics packages (R or Matlab) and SQL queries preferred • Highly self-motivated and demonstrated ability to manage internal and external collaborations

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