Bioinformatics Jobs

Company Summary: Arana Biosciences is one of the latest companies founded through Flagship Pioneering’s venture creation engine, where companies such as Moderna Inc. and Indigo Ag were conceived and created. Since Flagship’s founding in 2000, the firm has originated and fostered the development of nearly 100 scientific ventures resulting in $19+ billion in aggregate value, 500+ issued patents... and more than 50 clinical trials for novel therapeutic agents. Arana Biosciences is integrating the latest developments in molecular biology and plant biology to create a new platform technology that enables adaptive, targeted and sustainable solutions in agriculture. Data Engineer II, Bioinformatics Key Responsibilities:  • Design, create, and manage database systems that allow biologists to investigate data independently. • Automate workflows for data retrieval or storage in electronic lab notebooks (ELNs),such as Benchling. • Collaborate with a team of scientists to help automate data analysis pipelines and build data infrastructure. • Define, contribute to, and proactively communicate data engineering standards and practices establishing repeatable templates and frameworks and efficient usage of cloud services and tools. • Communicate insights and progress to the scientific team and executive management. Minimum Qualifications • B.S. or M.S. in computer science or related field and 3+ years of industry experience • Extensive experience with database technologies, architecture, and management. • Programming experience in scripting languages such as Python, R, SQL, and version control tools. • Understanding of ideating and creating UI design deliverables. • Working knowledge of AWS services, including EC2, S3, RDS, FSx Lustre, Athena, Glue, Lambda, Batch. • Application lifecycle knowledge, including best practices such as code review, unit/integration testing, and documentation. • Ability to design and implement backend models using logic and API endpoints for complex scientific workflows/entities (i.e.. Benchling). • Adaptive, creative, and a quick learner, efficient in multi-tasking and troubleshooting. • Demonstrated ability to successfully work in cross-functional and third-party teams with an emphasis on teamwork, collaboration, and communication. • Experience with workflow orchestration frameworks such as Nextflow, Snakemake, Airflow or AWS Step Functions. Preferred Qualifications • NGS pipeline development experience with virology, pathology, molecular biology, or similar datasets. • Ability designing and implementing a variety of software platforms through the API framework. • Familiarity with continuous integration/continuous deployment (CI/CD) pipelines. • Experience with data visualization tools, such as Tableau, Spotfire, or Retool. Location: Cambridge, MA More About Flagship Pioneering Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises transformative companies, including Seres Therapeutics (NASDAQ: MCRB), Indigo Ag, Invaio Sciences, Moderna (NASDAQ: MRNA), Generate Biomedicines, Denali Therapeutics (NASDAQ: DNLI), Senda Biosciences and Foghorn Therapeutics (NASDAQ: FHTX). Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto

Volta Labs is an MIT spin-off that has unlocked powerful new DNA sequencing capabilities by developing novel fluidic technology. Building off of this core technology, Volta has created a product that streamlines DNA sequencing sample prep. Volta is at the forefront of a sequencing revolution, driving sequencing towards seamless ease of use and complete automation. We a product and data-driven... company where employees are empowered to learn and thrive in a fast-paced, open, and collaborative environment. This is an exciting phase to join Volta; with commercialization imminent, our product has the potential to change the future of sequencing. The Team You'll join a team of innovative thinkers who aren't afraid to venture into new territories to build advanced automation systems. We are an incredibly supportive group that enjoys collaborating to overcome challenges and provide constructive feedback to help each other grow. We are passionate about pushing the boundaries of automation, biology, computing, robotics, design, and user experience to benefit our customers. As a core member of our team, you'll instill these values across the organization and play an integral role in helping grow the team. Join us if you want to make a meaningful impact on the future of technology while being part of a thoughtful, driven team. The Opportunity Volta is building a suite of genomics applications for its disruptive digital fluidics sample prep automation platform. Reporting to the Head of Applications Development and working closely with Scientists from the Application Development team, the ideal candidate will be responsible for the development of bioinformatic infrastructure as well as collaborating with Scientists to design experiments and analyze sequencing results. Responsibilities • Own the development and implementation of bioinformatic infrastructure to support internal research efforts and collaboration across the application development team. • Integrate bioinformatics algorithms into the company's software platforms, ensuring seamless compatibility with existing pipelines and workflows. • Collaborate with biologists, data scientists, and other software engineers to understand the specific requirements and constraints of NGS data analysis for internal research. • Support data analytics on a company-wide basis • Stay abreast of next-generation sequencing technologies and applications through scientific literature, conference attendance, customer interactions (mediated by the Commercial team) and provide inputs into the - Applications Development roadmap. • Actively participate in all hands-on work, identify problems and root causes, systematically troubleshoot and solve complex issues. • Conduct regular design reviews and report pro-actively to the broader team. Qualifications • 3-5+ years of industry experience (post-graduation) in the genomics/life sciences space • MSc or higher in bioinformatics, computer science, mathematics, statistics, or related disciplines. • Demonstrated experience with cloud computing infrastructure like AWS (EC2, S3, ECR). • Proficient with relevant bioinformatics tools and libraries. • Experience with containerization (Docker, Singularity). • Strong proficiency in Python. • Proficient with version control like Github or Gitlab. • Ability to analyze and synthesize, understand the bigger picture and master the fine details, think laterally, and solve technical and other problems creatively. • Self-motivated, ability to work independently, and report progress proactively and efficiently. • Proven ability to work collaboratively in a highly interdisciplinary environment. • Excellent verbal and written communication skills. • Continuous learner who embraces a growth mindset. This is a full-time position that requires a significant amount of in-person work and collaboration. We ask that you can come onsite to our Seaport Office in Boston, MA 5 days a week. Our Benefits And Perks Robust Equity Program, to build future wealth through stock options with high growth potential Comprehensive Healthcare Coverage, including Medical, Dental, & Vision HSA, FSA, and Sponsored Commuter Benefit Plans Access to Our 401K Plan, to save for your future 12 Weeks of Paid Parental Leave, which can be taken over 12 months Unlimited Paid Time Off, because we understand the importance of time off for rest and adventure 10 Paid Federal Holidays Twice Weekly On-site Lunches, variety snacks, beverages, & treats Weekly Paid Coffee Date with Colleague Monthly Team Happy Hours We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status, and we actively seek out and value diverse perspectives. Women, people of color, people who are differently abled, and members of the LGBTQ+ community are encouraged to apply. Even if you don't check every box, but see yourself contributing, please apply. Help us build an inclusive community that will change the face of bio-automation

About Us: As a not-for-profit organization, Mass General Brigham is committed to supporting patient care, research, teaching, and service to the community by leading innovation across our system. Founded by Brigham and Women's Hospital and Massachusetts General Hospital, Mass General Brigham supports a complete continuum of care including community and specialty hospitals, a managed care... organization, a physician network, community health centers, home care and other health-related entities. Several of our hospitals are teaching affiliates of Harvard Medical School, and our system is a national leader in biomedical research. We're focused on a people-first culture for our system's patients and our professional family. That's why we provide our employees with more ways to achieve their potential. Mass General Brigham is committed to aligning our employees' personal aspirations with projects that match their capabilities and creating a culture that empowers our managers to become trusted mentors. We support each member of our team to own their personal development-and we recognize success at every step. Our employees use the Mass General Brigham values to govern decisions, actions and behaviors. These values guide how we get our work done: Patients, Affordability, Accountability & Service Commitment, Decisiveness, Innovation & Thoughtful Risk; and how we treat each other: Diversity & Inclusion, Integrity & Respect, Learning, Continuous Improvement & Personal Growth, Teamwork & Collaboration. General Summary/ Overview: At Mass General Brigham Digital, we pride ourselves on our ability to create maximum strategic, clinical, and operational value from established and emergent technologies for our patients, care teams, researchers, and employees. Digital health will not only enhance the equity and efficiency of healthcare delivery, but it will also help make medicine more personalized and precise. We recognize that increasing value and continually improving quality while maintaining an inclusive focus are essential to organizational excellence, and we invite you to join us on this journey. The work we do in Digital is a strategic imperative, and there is a strong and growing understanding of how together we will transform Mass General Brigham in innovative and impactful ways. This is a position supporting MGB Pathology Informatics. Pathology Informatics drives the application of clinical bioinformatics, digital pathology, and other clinical/research/education informatics needs in the department. We develop and leverage software solutions and integrated data to improve the delivery of patient care. The successful candidate will join an existing informatics team which has developed, maintained, and continue to innovate/improve solutions for clinical pathology informatics. Position Summary: Reporting to DevOps Manager The Software Engineer II position requires expertise in various programming languages, database management, web development, and modern technology stacks to develop and maintain software solutions that support our clinical care, educational, and research initiatives. To excel in this dynamic and intellectually challenging position, the candidate must be adaptable, collaborative, and possess excellent technical and communication skills. The full-time position is remote, requiring prompt availability on our business communication platform during business hours. The incumbent participates in the design, development, testing, and implementation of new software solutions in collaboration with MGB Resources. This includes but is not limited to improving operations in the anatomic pathology and laboratory medicine divisions of the pathology department. S/he understands the need to acquire new skills and understand contemporary concepts, including standards (e.g., FHIR, DICOM), to enrich the development of new and existing software products. The incumbent will provide on-going support of live applications, focusing on troubleshooting and problem-solving, ensuring the reliability and functionality of existing systems. S/he is responsible for being able to identify complex problems in existing applications, their probable causes, and their impact on operations, report them to the appropriate parties, and offer possible solutions. S/he is able to independently and/or collaboratively bring code bugs and other issues to complete resolution and acts as a liaison to user groups. S/he pursues opportunities for self-development and demonstrates a commitment to excellence and delivery of high-quality customer service. Principal Duties and Responsibilities: Software Engineer II can handle more complex tasks independently and may work on larger components of a project. They have a deeper understanding of the codebase and contribute to design decisions. Possess ability to work more autonomously and require less supervision by management. Take on multiple coding tasks/projects at the same time. Staff levels employees have a proven record of diagnosing and solving problems in a multi-task environment and are able to prioritize tasks effectively. Perform Clinical Production Support and help pathologists and scientists in resolving issues independently Possess excellent communication skills. Design and develop software solutions that meet product requirements. Collaborate with product managers and stakeholders to gather and refine software requirements. Implement and maintain software features and improvements. Conduct thorough testing and debugging to ensure the quality and reliability of the software. Train junior engineers and provide technical guidance. Design, implement, test, maintain and support web applications for clinical lab informatics, bioinformatics, digital pathology, anatomic pathology, and clinical pathology Practices software development, unit testing, integration testing, code review, documentation, and version control Improve the current pipeline automation by developing on the feature requests and enhancements from the end users Collaborate with other IS group staff on the development of software and custom scripts to automate data retrieval, improve user interfaces, create new statistical tools and reports, etc.. Independently design new tools to improve operations in the Department of Pathology. Performs all other duties as assigned. Bachelors degree in bioinformatics, computer science and/or the life sciences Required. Generally hold a Masters degree and 3-5 years of experience or a Ph.D with 0-3 yrs of experience. Programming using C#, ASP.NET/Python SQL proficiency using SQL Server Services and Web API development using C# (Experience with Java, Perl, Node JS is a plus) Formal agile software development Formal experience with continuous integration/continuous development Experience working in clinical health care preferred. Strong understanding of software design patterns and principles. Familiarity with version control systems and agile development methodologies. Skills/Abilities/Competencies: Back end and API development using Python, or NodeJS or C#, Java, R, Perl (Fast API is a plus). SQL proficiency using MySQL and/or SQL Server, knowledge of NoSQL and other DBMS (e.g., PostgreSQL, MongoDB, Apache CouchDB) a plus Web development using Angular 6 , Python Flask (ASP.NET would be a plus). Experience with backend programming languages such as python, PHP, or Java preferred Experience in RESTful programming, designing RESTful APIs, deploying web services, and configuring web servers (e.g., Apache, NGINX) Experience with Linux container engines and container orchestration systems (e.g., Docker, Kubernetes) preferred Experience with cloud computing a plus Experience with workflow management platforms a plus (Airflow, Argo) Familiarity SDLC principles. Strong interpersonal skills and ability to effectively interact with all levels of staff and external contacts. Excellent analytical, organizational and time management skills. Ability to work in a highly collaborative and intellectually challenging environment Excellent oral and written communication skills Ability to rapidly assess, learn, and implement new technologies / services as new needs arise, as well as communicating use of those technologies Excellent attention to detail Ability to work independently, self-motivated Strong communication skills to be able to work effectively with multidisciplinary staff, interacting with individuals at many levels of multiple institutions Working Conditions: The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. This position requires occasional local travel to MGB sites, vendors, and/or conferences Hospital work environment working conditions include possible exposure to diseases or infections and may require safety gear (PPE) such as gloves and mask. Normal office working conditions. The noise level in the work environment is quiet to moderate. While performing the duties of this job, the employee is frequently required to sit; talk; or hear; use hands to finger; handle; or feel; reach with hands and arms. The employee is occasionally required to stand; walk; and stoop; kneel; or crouch. The employee must frequently lift and/or move up to 5 pounds and occasionally lift and/or move up to 20 pounds. Specific vision abilities required by this job include close vision, distance vision and depth perception

When you join the growing BILH team, you're not just taking a job, you’re making a difference in people’s lives. Job Type... Regular Scheduled Hours: 40 Work Shift: Day (United States of America) About us: The BIDMC Bioinformatics Core (BBC) is part of the Precision RNA Medicine Core at Beth Israel Lahey Health. The BBC will be tightly integrated with the ‘Omics cores at BIDMC. It is the center for bioinformatics research expertise at BIDMC. We work directly with biomedical scientists across our Network and the Harvard community to implement best practice for analysis, interpretation, visualization, and dissemination of scientific discoveries using high dimensional data. The BBC team focuses on teamwork and we provide a supportive learning environment. About you: You understand the growing need for data driven research. You have a solid track record in bioinformatics service provision, excellence in communication skills and written and verbal reporting. A thorough knowledge of current and upcoming developments in analysis of high dimensional data, genomics and the current developments in bioinformatics are essential. Management skills should be evident, with a particular focus upon project management, the ability to define specific project requirements and to execute upon specifications. Evidence of having managed developers is of value. Publications should reflect a collaborative approach – with diversity of subjects being of interest. You should be able to articulate the vision of the program, and must be able to work independently. You are not shy of taking on core projects where you provide direct consulting, or work with teams to provide consulting to biomedical researchers. Your background is in biomedical/quantitative science with evidence of strong interest in working with researchers in diverse areas of biomedical research. You thrive on scientific challenges, enjoy collaborating with an interdisciplinary team and excel at communicating and coordinating between computational and wet-lab scientists. Learning and applying new methods is natural for you, and you are motivated to continuously expand your skills. You have superb data and project management skills. Working on different projects and deadlines, frequently in collaboration with other Cores and research groups, does not intimidate you. Job Description: Job Summary: The Bioinformatics Core Director will have strategic and tactical responsibility for the operations of the core, consultation, recruiting, overseeing core support staff and provision of leadership in developing core resources and providing research support and training for research faculty and staff at BIDMC. The Core Director will lead a team that develops and applies bioinformatics workflows for standard and custom data analysis across a broad range of technologies, such as single nuclei sequencing, spatial transcriptomics, genome variant analyses, transcriptomics or epigenomics. The Core Director is expected to create deliverables that could serve as standards for quality and innovation in broader communities, building informatics tools for data management, omics and imaging analyses within the reality of clinical data integration. The team will support researchers across the research community with their data management, quality control, analysis of data and presentation of results and will also be expected to coordinate selected research or support projects and act as an independent point of contact for researchers. Essential Responsibilities: 1. Determine BIDMC needs and work with core Scientific Directors in setting strategic, scientific and operational priorities. 2. Provide best practice bioinformatics services to investigators across campus, including pre-experiment/grant consulting, application and training on the use of bioinformatics core software tools, and integration of user-generated and large-scale public data sets. 3.Develop staffing plans and oversee recruitment; oversee developers as necessary, provide management of database design, interface design and information processing. 4. Co-ordinate a monthly seminar series, special trainings and mini-courses and organize user groups for bioinformatics related activities. 5. Develop and promote the funding model for expansion and sustainability of the core, including investments from organizational units around the community, charge-back models and collaborative grant applications to ensure long term sustainability. 6. Lead and collaborate on grant applications related to bioinformatics core projects. 7. Enable implementation of scalable workflows to disseminate analytical advances to the research community. 8. Engage with the community to both embrace and develop best practice. 9. Participate in leading national and international efforts aimed at establishing best practices and standards for omics basic science and potentially integration with clinical data representation and analysis. 10. Has full responsibility for planning, monitoring and managing department budget. Required Qualifications: Master's degree required; Doctoral degree preferred. 5-8 years related work experience required and 5-8 years supervisory/management experience required Demonstrated excellence in analytical, writing, and communication skills; A commitment to providing bioinformatics support for a broad range of scientific projects; Experience in developing and managing projects and people. Extensive knowledge of public domain bioinformatics data sources, public sequence databases, genomics tools, single cell analyses, and gene expression analysis. Evidence of software development experience and proficiency in scripting; Experience with SQL or other relational database systems, Unix and mixed operating systems environments, high-dimensional data management and analysis; Proficient in R and Bioconductor. Advanced skills with Microsoft applications which may include Outlook, Word, Excel, PowerPoint or Access and other web-based applications. May produce complex documents, perform analysis and maintain databases. Competencies: Decision Making: Ability to make decisions that are guided by general instructions and practices requiring some interpretation. May make recommendations for solving problems of moderate complexity and importance. Problem Solving: Ability to address problems that are varied, requiring analysis or interpretation of the situation using direct observation, knowledge and skills based on general precedents. Independence of Action: Ability to set goals and determines how to accomplish defined results with some guidelines. Manager/Director provides broad guidance and overall direction. Written Communications: Ability to communicate complex information in English effectively in writing to all levels of staff, management and external customers across functional areas. Oral Communications: Ability to verbally communicate complex concepts in English and address sensitive situations, resolve conflicts, negotiate, motivate and persuade others. Knowledge: Ability to demonstrate in-depth knowledge of concepts, practices and policies with the ability to use them in complex varied situations. Team Work: Ability to lead and direct multiple collaborative teams for large projects or groups both internal and external to the Medical Center and across functional areas. Results have significant implications for the management and operations of the organization. Customer Service: Ability to lead operational initiatives to meet or exceed customer service standards and expectations in assigned unit(s) and/or across multiple areas in a timely and respectful manner. Physical Nature of the Job: Sedentary work: Exerting up to 10 pounds of force occasionally in carrying, lifting, pushing, pulling objects. Sitting most of the time, with walking and standing required only occasionally FLSA Status: Exempt As a health care organization, we have a responsibility to do everything in our power to care for and protect our patients, our colleagues and our communities. Beth Israel Lahey Health requires that all staff be vaccinated against influenza (flu) and COVID-19 as a condition of employment. Learn more about this requirement. More than 35,000 people working together. Nurses, doctors, technicians, therapists, researchers, teachers and more, making a difference in patients' lives. Your skill and compassion can make us even stronger. Equal Opportunity Employer/Veterans/Disabled

Bioinformatics and Molecular Data team is a growing group at the Informatics and Analytics Department (I&A) of Dana-Farber Cancer Institute (DFCI). The team addresses unmet needs for bioinformatics, data management, data mining and analysis across research, clinical, and operational units. It accelerates use of bioinformatics and data science methods, data, and tools within DFCI, bridging the gap... between research and clinical practice and helping design and implement operational solutions. The group encompasses expertise in bioinformatics, data science, machine learning, and software engineering. It works with some of the most prominent research and clinical DFCI programs, from basic research to translational research, to clinical diagnostics and operations. We look for an intelligent, hard-working, and dynamic individual to fill the role of Bioinformatics Scientist in the team. The successful candidate will support key initiatives relying on genomic data, have the ability to lead projects and potentially, in the future, may lead other people within the team. Specifically the role will work on an exciting new initiative to develop a cloud-based bioinformatics analysis platform. The platform will enable DFCI researchers to easily manage and analyze their genomic and biomedical data in the cloud environment, build and run analysis workflows and visualize the results. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The successful candidate will have proven experience in managing and independently executing complex bioinformatics tasks in the frame of Bioinformatics Workbench project. The role’s responsibilities will include: • Owning and leading various projects, serving as a subject matter expert. • Developing and implementing bioinformatics tools and pipelines in cloud environment. • Collaborating with DFCI software engineering and data science teams as well as interacting with external cloud and other technology vendors. • Meeting, consulting, and providing computational and informatics support to various DFCI scientists and independent faculty members in designing and executing key biomedical projects. • Collecting, analyzing, interpreting, and integrating complex biomedical data. • Delivering results for projects and generating relevant reports. • Working as a part of the broader team to identify and implement longer-term solutions that will improve quality, speed and efficacy of our current projects and programs through evaluating and benchmarking new software tools and pipeline development. • Contributing expertise to DFCI software code base and communities of practice. Minimum Education: Bachelor’s degree required in a STEM field. Master’s degree or PhD strongly preferred in bioinformatics, medical informatics, computational biology, statistics, computer science/engineering, or a related quantitative field. Minimum Education: 3 Years of experience required; Master’s degree with 1 year experience required; PhD with 0 years. • Deep bioinformatics skills at the interface between bioinformatics programming and understanding of biological and clinical problems. • Experience in analysis of the next generation sequencing data, e.g. WXS/WGS, RNA-Seq, etc; experience in single-cell and/or ctDNA data analysis is a plus. • Working knowledge of IA and machine learning approaches used in bioinformatics research • Experience in one or more areas of cancer research, including solid tumors, hematologic malignancies, patient-derived cancer models, biomarker discovery, etc. is a major plus. • Excellent communication and effective problem-solving skills, track record in serving a variety of diverse customers and projects. • Proven ability to work independently, prioritize, and manage people if needed, within an environment with evolving priorities. At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. EEOC Poster

At Boston Children’s Hospital, the quality of our care – and our inclusive hospital working environment – lies in the diversity of our people. With patients from local communities and 160 countries around the world, we’re committed to reflecting the spectrum of their cultures, while opening doors of opportunity for our team. Here, different talents pursue common goals. Voices are heard and ideas... are shared. Join us, and discover how your unique contributions can change lives. Yours included. Job Summary Research Computing at Boston Children’s supports basic, translational, and clinical research by providing researchers with access to digital tools and technologies. Our computing environment consists of high-performance computing clusters, virtual machines, PetaByte-scale high-performance storage and cloud platforms. We work with BCH scientists to develop solutions in support of cutting-edge research ranging from lattice light-sheet microscopy to CryoEM, genomics, and informatics. The role will work with PhD-level bioinformatics scientists and researchers who have single-cell RNA-seq, single-cell ATAC-seq, spatial transcriptomics, bulk RNA-seq and ChIP-seq data to investigate the vascular complications of diabetics and other mouse and human diseases as well as with other pediatric scientists at BCH. The primary responsibilities will be building pipelines for the analysis, integration and sharing of these data. You will analyze, integrate different types of next-generation sequencing data and interpret the results and will have the opportunity to publish high-profile papers with prominent authorship depending on the intellectual contribution. The ideal candidate should have enthusiasm for developing collaborative relationships and a desire to foster the use of bioinformatics data in research studies. The Bioinformatics Scientist shall be responsible for: • Providing computational support services to Boston Children’s Hospital scientists and clinicians by applying a wide range of bioinformatics tools, methods and technologies. • With supervision and direction, completing assignments in the required timeframe while consistently adhering to standard operating procedures and best practices; adapting to a changing environment, resolving problems associated with assignments and seeking supervisor assistance when needed. • Participating and/or co-leading Research Computing projects with other members from the BCH research community; setting goals and objectives for projects and demonstrating achievement of those goals and objectives. • Training staff and researchers; effectively tailoring presentations; developing, implementing and maintaining knowledge management systems. • Creating or contributing to a range of compelling communications (e.g. PowerPoint presentations, e-mails, memos, scientific presentations, and publications) that clearly deliver content; preparing communications appropriate for management and internal distributions. In order you qualify, you must have: • Minimum of 4-year Bachelor’s degree in STEM. Minimum of one year of advanced bioinformatics experience. Preference for candidates with a Ph.D. in Bioinformatics, Computational Biology or related. • Extensive knowledge of the use of bioinformatics computations in high-performance computing environments, including open-source bioinformatics software and pipelines to support diverse bioinformatics analyses such as single-cell RNA-seq, bulk RNA-seq, ChIP-seq, methylation, etc. • Extensive knowledge of technologies used in support of biomedical research, such as programming languages (R and Python), databases (SQL), version control (Git), scientific workflow tools and high-performance computing clusters. Cloud computing tools would be a bonus. • Strong publication record. Ability to effectively convey messages through written communication that are tailored to target audiences; meeting discussions and one-on-one verbal communications are clear and effective; ability to conduct effective meetings, to present in departmental and hospital forums and to develop training instructions and manuals. Boston Children’s Hospital offers competitive compensation and unmatched benefit, generous levels of time off, 403(b) Retirement Savings and Pension Plan. Experience the benefits of passion and teamwork. Please note: During a public health emergency, individuals in this role may be expected to take on additional duties to respond to organizational needs. Boston Children’s Hospital requires all employees to be vaccinated against COVID-19 and Flu, (unless you are eligible for a medical or religious exemption). Boston Children’s Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability. Status Full-Time Standard Hours per Week 40 Job Category Information Technology Regular, Temporary, Per Diem Regular Office/Site Location Boston

• Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and... comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. • We seek an enthusiastic and highly motivated bioinformatics associate to join our cancer genomics research group. This individual will join oncologists, computational biologists and research scientists on our effort aimed at studying the relationships between cancer causing genomic alterations and clinical outcome. This position will provide ample opportunities for professional development and the acquisition of cutting-edge skills in basic and translational cancer genomics research, research planning and strategy, and data analysis and interpretation. • This individual will analyze cancer genomic data generated at Dana Farber using software tools within our team and by generating their own statistical analysis code. This individual will collaborate with oncologists, computational biologists and research scientist to study alterations in patients’ somatic genomes in order to assist in finding new cancer treatments and cures. • Works in teams with oncologists, research scientist and molecular biologists to define and execute computational approaches. • Performs computational analysis of next generation sequencing data, somatic copy number alterations, expression profiling, and biological pathways using in house algorithms. • Generates own code to conduct various other statistical analyses including those to discover relationships between cancer alterations and clinical correlates. • Presents data at project team meetings. • Assists in drafting of scientific manuscripts. • This employee will be located at both the Dana-Farber Longwood Medical Area campus and at the Broad Institute in Cambridge. At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. • Required: B.S./B.A. in the life sciences, physical sciences, or computational sciences. Some coding knowledge of either R, Matlab, and/or python. The ability to work in teams, excellent communication and data presentation skills. • Preferred: Background in molecular genetic data. Understanding of statistical methods and working in cloud computing and UNIX environments. • We will consider May 2024 graduates. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law. EEOC Poster

This is what you will do: As an integral part of Alexion’s Bioinformatics and Data Sciences team, your role involves creating and developing bioinformatics and data science solutions to advance the AAV gene therapy platform. You'll be part of a skilled team dedicated to generating strategic value and driving innovation throughout Alexion through the creative use of data sciences. You will need... to effectively collaborate with other colleagues at Alexion with diverse scientific backgrounds to deliver novel quantitative solutions and analyses. You will be responsible for: • The successful candidate will collaborate effectively with research teams and will own the development of computational solutions to design, develop, and optimize capsids and transgene cassettes for the novel AAV (adeno-associated virus) development. • Implement computational tools, lead experiment design, analyze studies/assays (such as DNAseq, RNAseq, Single Cell sequencing), interpret results, offer project projections, communicate findings, and uphold active program timelines. • Work both independently and as part of a collaborative team to apply innovative data analysis and AI/ML approaches • Develop software tools and scripts to support data analysis and interpretation pipelines. Practice reproducible research and version control in data analysis. • Lead efforts to identify key needs and questions that can be addressed using genetics, Omics or other bioinformatics approaches in collaboration with multi-functional research teams • Stay up-to-date with relevant scientific literature and incorporate new innovations into research activities and evaluation of new technologies and methods You will need to have: • PhD (or equivalent degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field, with strong background in data science and machine learning, 5+ years of related experience (including post-doc experience) • Significant experience in AAV design and engineering • Solid training and experience of machine learning/ artificial inteligence/ network modeling, strong programming skills in R and/or Python and familiar with Unix/Linux and high-performance computing environments • Proven track record in the analysis, visualization, and interpretation of genetics and Omics data • Strong knowledge of human genetics, molecular biology, as well as biological pathways and networks • Be able to work independently with both internal and external diverse team stake holders and contributors • Excellent communication and presentation skills with specific experience in cross functional collaborations.. • The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees will, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. We would prefer for you to have: • Familiarity with concepts, tools and data formats used for sequence analysis, protein structure modeling and integration of diverse -omics datasets • Familiarity with computational protein modeling and structural biology AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law. Expectation of working in the office 4 days a week statement: When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of four days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world

***LOCAL CANDIDATES ONLY. NO RELOCATION OR SPONSORSHIP AVAILABLE FOR THIS ROLE.***Pay: $65-77/hour Details: 1 Year Contract... Qualifications: Work location is either Boston or Cambridge MA, Education Minimum Requirement: • Ph.D. in Bioinformatics, Biostatistics, Computational biology, Computer Science, Genetics, Immunology, Mathematics, Molecular Biology, Statistics, or related field • Masters degree in the above disciplines, with 3 years of relevant experience • B.S with 6+years of relevant experience. Required Experience and Skills: • Passion to solve biological problems and identify problems that can be efficiently solved through computational methods and algorithms. • Experience with computational analysis and biological interpretation of diverse large-scale NGS experimental datasets • Proficiency in at least one statistical programming language, such as R or Python • Familiarity with public databases, and repositories of DNA, RNA and single cell profiling data • Skilled at integrating results generated from multiple omics data sources, and biological knowledge bases to customize analytical approaches for discovery research. • Interest in identifying novel applications of AI / machine learning strategies for biological target discovery. • Demonstrate the ability to learn, be proactive and motivated, and consistently focus on details and execution. • Excellent oral and written communication skills P • Previous experience with experimental design of biological assays, statistical hypothesis testing, and biological interpretation • Understanding the pros and cons of various algorithms for DNA-seq, RNA-seq, single-cell RNA-seq and/or functional genomics data • Experience with version control environments, such as Git • Experience with high-performance Linux cluster and cloud computing Responsibilities: The Data, AI & Genome Sciences department is looking for a passionate and talented computational biology scientist to join our Computational Biology and Genomics research team for a contract role based in Cambridge / Boston, MA. In this role, you will apply machine learning and bioinformatics approaches to analyze large multi-scale and multi-omics datasets in collaboration with cross-functional teams of computational biologists, data scientists and colleagues in Discovery Research to support target discovery and drug development efforts. Oncology research is driven by a deep interest in the biology of tumor and its microenvironment, and how diverse points of intervention can be combined to achieve ever higher rates of durable response and patient overall survival. In this exciting role, you will: * Contribute to multiple stages of drug discovery to decode genetic dependencies and identify therapeutic targets by interrogating high-throughput assays, including genomics, transcriptomics, and proteomics datasets. * Collaborate with experimental scientists across functions to characterize novel targets coming from genetics, translational and disease pathway exploration, explore target engagement, research mechanisms of action, and provide functional validation of novel drug targets. * Work with large internal and public biological data sets including Next Generation Sequencing (NGS) data (e.g. RNA-Seq, Perturb-Seq, single cell RNA-Seq, WGS, CRISPR) * Be proactive and work collaboratively across disciplines, including molecular biologists, protein scientists, bioinformaticians, and software engineers. * Employ best reproducible research and data integrity practices to generate reusable analysis frameworks and reports to support Discovery Oncology target identification and validation efforts

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute (DFCI) brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and... comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The Department of Informatics and Analytics (I&A) at Dana-Farber has multiple openings for highly motivated bioinformatics software or data engineers who are passionate about the potential for molecular data to inform clinical care of cancer patients and the groundbreaking discoveries that are a product of genomic data integration and analysis. The qualified candidate will work on an exciting initiative to build a cloud-based bioinformatics analysis platform. The platform will enable researchers at DFCI to easily manage their genomic and biomedical data in the cloud environment, select and kick off containerized NGS analysis workflows, monitor the execution status and eventually visualize the results. The successful candidate is expected to collaborate with functional teams such as Bioinformatics and Data Engineering, and cloud and other technology vendors. • Integrate a wide variety of tested computational tools and pipelines into cloud environment • Actively participate in designing scalable, highly available, secure, cost-effective cloud-based solutions • Collaborate with bioinformaticians and engineers to containerize new or existing analysis pipelines and make pipelines portable on both on-prem high-performance computing and cloud environments • Design, implement, and maintain scalable pipeline workflows to automate multi-step computing tasks required for various data analysis scenarios • Develop and maintain the automated tests and monitoring process to ensure the successful pipeline execution and deployment • Assist product management for the documentation of the system requirements, design, and troubleshooting • Provide technical support to end users for pipeline deployment and execution • Apply industry best practices and act as an advocate for coding standards and test-driven development • Mentor new team members Qualifications: • Bachelor’s degree required, MS preferred, in Bioinformatics, Computational Biology, Data Science, Computer Science, Software Engineering, or related discipline • Demonstrated proficiency with Python, R, Perl and/or other languages • Experience with data analysis in cloud environment, especially Microsoft Azure • Proficient with Linux environment, shell scripting, and command line tools • Experience with software development and Agile process is a strong plus SKA’s: • Enthusiastic about data security, process automation, and innovation • Familiar with distributed code versioning tools such as Git, GitHub, Bitbucket • Detail oriented with ability to gain deep understanding of technical systems • Excellent interpersonal skills, passionate about innovative solutions • Familiarity with bioinformatics workflow management such as Cromwell and Nextflow Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law. EEOC Poster